The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults.

BACKGROUND: Previous meta-analyses estimating the prevalence of the post-COVID-19 condition (PCC) were confounded by the lack of negative control groups. This may result in an overestimation of the prevalence of those experiencing PCC, as these symptoms are non-specific and common in the general population. In this study, we aimed to compare the burden of persistent symptoms among COVID-19 survivors relative to COVID-19-negative controls. METHODS: A systematic literature search was conducted using the following databases (PubMed, Web of Science, and Scopus) until July 2023 for comparative studies that examined the prevalence of persistent symptoms in COVID-19 survivors. Given that many of the symptoms among COVID-19 survivors overlap with post-hospitalization syndrome and post-intensive care syndrome, we included studies that compare the prevalence of persistent symptoms in hospitalized COVID-19 patients relative to non-COVID-19 hospitalized patients and in non-hospitalized COVID-19 patients relative to healthy controls that reported outcomes after at least 3 months since infection. The results of the meta-analysis were reported as odds ratios with a 95% confidence interval based on the random effects model. RESULTS: Twenty articles were included in this study. Our analysis of symptomatology in non-hospitalized COVID-19 patients compared to negative controls revealed that the majority of symptoms examined were not related to COVID-19 infection and appeared equally prevalent in both cohorts. However, non-COVID-19 hospitalized patients had higher odds of occurrence of certain symptoms like anosmia, ageusia, fatigue, dyspnea, and brain fog (P < 0.05). Particularly, anosmia and ageusia showed substantially elevated odds relative to the negative control group at 11.27 and 9.76, respectively, P < 0.05. In contrast, analysis of hospitalized COVID-19 patients compared to those hospitalized for other indications did not demonstrate significantly higher odds for the tested symptoms. CONCLUSIONS: The persistent symptoms in COVID-19 survivors may result from hospitalization for causes unrelated to COVID-19 and are commonly reported among the general population. Although certain symptoms exhibited higher odds in non-hospitalized COVID-19 patients relative to controls, these symptoms are common post-viral illnesses. Therefore, the persistent symptoms after COVID-19 may not be unique to SARS-CoV-2. Future studies including well-matched control groups when investigating persistent symptoms in COVID-19 survivors are warranted to draw a firm conclusion.

Mid-infrared optical modulator based on silicon D-shaped photonic crystal fiber with VO2 material.

Recently, photonic crystal fibers (PCFs) have become of significant interest due to their various applications, especially in the mid-infrared (mid-IR) regime. In this work, an optical mid-IR modulator based on silicon D-shaped PCF (Si-D-PCF) with vanadium dioxide (VO2) as a phase changing material (PCM) is presented and analyzed. Thanks to the phase transition of the VO2 material between insulating (ON) and conducting (OFF) states, the modulation process can be attained. The well-known full vectorial finite element method is utilized to numerically analyze the proposed design. Further, the propagation of light through the suggested structure is studied using the 3D finite difference time domain method. The optical losses of the fundamental TM mode supported by the Si-D-PCF structure in both ON and OFF states are investigated. The obtained results reveal that the extinction ratio (ER) of the reported modulator approaches 236 dB, while the insertion loss (IL) is less than 1.3 dB over the studied wavelength range 3-7 µm at a device length (LD) of 0.5 mm. Additionally, the ER of the proposed modulator is higher than 56 dB through the whole studied wavelength range. Therefore, the proposed modulator could be utilized in photonic integrated circuits that require high ER, low IL, and large bandwidth. To the best of the authors' knowledge, this is the first time an infrared optical modulator based on Si-D-PCF with VO2 material has been presented.