Looking on the (B)right Side of Life: Cognitive Ability and Miscalibrated Financial Expectations.

It is a puzzle why humans tend toward unrealistic optimism, as it can lead to excessively risky behavior and a failure to take precautionary action. Using data from a large nationally representative U.K. sample (N=36,312), our claim is that optimism bias is partly a consequence of low cognition-as measured by a broad range of cognitive skills, including memory, verbal fluency, fluid reasoning and numerical reasoning. We operationalize unrealistic optimism as the difference between a person's financial expectation and the financial realization that follows, measured annually over a decade. All else being equal, those highest on cognitive ability experience a 22% (53.2%) increase in the probability of realism (pessimism) and a 34.8% reduction in optimism compared with those lowest on cognitive ability. This suggests that the negative consequences of an excessively optimistic mindset may, in part, be a side product of the true driver, low cognitive ability.

Cognitive ability and voting behaviour in the 2016 UK referendum on European Union membership.

On June 23rd 2016 the UK voted to leave the European Union. The period leading up to the referendum was characterized by a significant volume of misinformation and disinformation. Existing literature has established the importance of cognitive ability in processing and discounting (mis/dis) information in decision making. We use a dataset of couples within households from a nationally representative UK survey to investigate the relationship between cognitive ability and the propensity to vote Leave / Remain in the 2016 UK referendum on European Union membership. We find that a one standard deviation increase in cognitive ability, all else being equal, increases the likelihood of a Remain vote by 9.7%. Similarly, we find that an increase in partner's cognitive ability further increases the respondent's likelihood of a Remain vote (7.6%). In a final test, restricting our analysis to couples who voted in a conflicting manner, we find that having a cognitive ability advantage over one's partner increases the likelihood of voting Remain (10.9%). An important question then becomes how to improve individual and household decision making in the face of increasing amounts of (mis/dis) information.

Gender differences in optimism, loss aversion and attitudes towards risk.

Systematic differences in the attitudes of men and women towards risk is well established. In this paper, we investigate the joint role of two prominent psychological characteristics in explaining this difference. Our starting point is that risk assessments can be thought of, in general terms, to combine beliefs about the probability of negative outcomes occurring with a subjective valuation of how painful that negative outcome would be. Exploiting large-scale panel data from the United Kingdom, we find that gender differences in financial optimism and financial loss aversion - the stronger psychological response to monetary losses than monetary gains - explain a substantial proportion of the parallel gender difference in willingness to take risks. This result prevails even after controlling for the Big Five personality traits, suggesting that the prominent psychological characteristics capture different aspects of behaviour than the Big Five.

Fusion-based quantum computation.

The standard primitives of quantum computing include deterministic unitary entangling gates, which are not natural operations in many systems including photonics. Here, we present fusion-based quantum computation, a model for fault tolerant quantum computing constructed from physical primitives readily accessible in photonic systems. These are entangling measurements, called fusions, which are performed on the qubits of small constant sized entangled resource states. Probabilistic photonic gates as well as errors are directly dealt with by the quantum error correction protocol. We show that this computational model can achieve a higher threshold than schemes reported in literature. We present a ballistic scheme which can tolerate a 10.4% probability of suffering photon loss in each fusion, which corresponds to a 2.7% probability of loss of each individual photon. The architecture is also highly modular and has reduced classical processing requirements compared to previous photonic quantum computing architectures.

Use of ammonium sulphate as a sulphur fertilizer: Implications for ammonia volatilization.

Ammonium sulphate is widely used as a sulphur (S) fertilizer, constituting about 50% of global S use. Within nitrogen (N) management, it is well known that ammonium-based fertilizers are subject to ammonia (NH3) volatilization in soils with pH > 7, but this has been overlooked in decision making on S fertilization. We reviewed 41 publications reporting measurements of NH3 loss from ammonium sulphate in 16 countries covering a wide range of soil types and climates. In field experiments, loss was mostly <5% of applied N in soils with pH (in water) <7.0. In soils with pH > 7.0, there was a wide range of losses (0%-66%), with many in the 20%-40% range and some indication of increased loss (ca. 5%-15%) in soils with pH 6.5-7.0. We estimate that replacing ammonium sulphate with a different form of S for arable crops could decrease NH3 emissions from this source by 90%, even taking account of likely emissions from alternative fertilizers to replace the N, but chosen for low NH3 emission. For every kt of ammonium sulphate replaced on soils of pH > 7.0 in temperate regions, NH3 emission would decrease from 35.7 to 3.6 t NH3. Other readily available sources of S include single superphosphate, potassium sulphate, magnesium sulphate, calcium sulphate dihydrate (gypsum), and polyhalite (Polysulphate). In view of the large areas of high pH soils globally, this change of S fertilizer selection would make a significant contribution to decreasing NH3 emissions worldwide, contributing to necessary cuts to meet agreed ceilings under the Gothenburg Convention.

Neither an Optimist Nor a Pessimist Be: Mistaken Expectations Lower Well-Being.

This article speaks to the classic view that mental health requires accurate self-perception. Using a representative British sample (N = 1,601) it finds that, as measured by two established well-being indicators, those with mistaken expectations, whether optimistic or pessimistic, do worse than realists. We index unrealistic optimism as the difference between financial expectations and financial realizations measured annually over 18 years. The effects are not small, with those holding the most pessimistic (optimistic) expectations experiencing a 21.8% (13.5%) reduction in long-run well-being. These findings may result from the decision errors and counteracting emotions associated with holding biased beliefs. For optimists, disappointment may eventually dominate the anticipatory feelings of expecting the best while for pessimists the depressing effect of expecting doom may eventually dominate the elation when the worst is avoided. Also, plans based on inaccurate beliefs are bound to deliver worse outcomes than would rational expectations.

Is temporary employment a cause or consequence of poor mental health? A panel data analysis.

Mental health status has an association with labour market outcomes. If people in temporary employment have poorer mental health than those in permanent employment then it is consistent with two mutually inclusive possibilities: temporary employment generates adverse mental health effects and/or individuals with poorer mental health select into temporary from permanent employment. We apply regression analyses to longitudinal data corresponding to about 50,000 observations across 8000 individuals between 1991 and 2008 drawn from the British Household Panel Survey. We find that permanent employees who will be in temporary employment in the future have poorer mental health than those who never become temporarily employed. We also reveal that this relationship is mediated by greater job dissatisfaction. Overall, these results suggest that permanent workers with poor mental health appear to select into temporary employment thus signalling that prior cross section studies may overestimate the influence of employment type on mental health.

Effect of processing conditions on trace elements in fish roe from six commercial new zealand fish species.

The concentrations of trace elements in fish roes and the effect of processing conditions (karasumi-like or karashi mentaiko) were investigated in six commercial fish species from New Zealand. The studied elements were As, Cd, Cr, Cu, Hg, Pb, and Zn, and the roes were from the following species: chinook salmon ( Oncorhynchus tshawytscha), hoki ( Macruronus novaezelandiae), southern blue whiting ( Micromesistius australis), hake ( Merluccius australis), blue warehou ( Seriolella brama), and barracouta ( Thyrsites atun). The concentrations of As, Cd, Cr, Hg, and Pb in the roes were lower than literature values for fish muscles. Only Zn in barracouta roe and Cu in salmon roe and their products were relatively higher than the generally accepted levels in fish muscles and could be of safety concern. Hence, the consumption of barracouta and salmon roes among certain parts of the population needs to be monitored and assessed. Dry salting (karasumi-like) processing increased ( P < 0.001) the concentrations of the studied trace elements while salting fermentation (karashi mentaiko) processing tended to decrease the levels of trace elements. Fermentation may be a useful process to decrease the level of toxic trace elements.

Pneumopericardium: a rare complication of laparoscopic varicocoele ligation.

Although symptomatic pneumopericardium post-laparoscopic varicocoele ligation procedure is rare, numerous cases have been reported and identified pneumopericardium as a complication of laparoscopic surgery. Pneumopericardium after other urological procedures has been previously reported when diagnosed incidentally on chest X-ray but there are no reports of symptomatic presentation. We hereby present the first symptomatic pneumopericardium case after a routine procedure for the ligation of varicocoele.

Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth.

CD40, a tumour necrosis factor (TNF) receptor family member, is expressed in a variety of cell types, including B lymphocytes, macrophages, fibroblasts, endothelial and epithelial cells, and this widespread expression is likely to account for its central role in normal physiology and disease pathogenesis. In this study, we provide evidence to support a role for constitutive CD40 signalling in cell transformation. We show that the ligand for CD40 (CD40L/CD154) is expressed in CD40-positive human breast tumour biopsies, suggesting that the constitutive activation of the CD40 receptor in vivo may contribute to the oncogenic process. Coexpression of CD40 and CD40L confers oncogenic effects on immortalized human epithelial cells in vitro, increasing their proliferation, motility and invasion. Expression of LMP:CD40, a hybrid molecule comprising the N-terminus and transmembrane domains of the Epstein-Barr virus-encoded latent membrane protein-1 (LMP1) fused to the cytoplasmic tail of CD40, mimics a constitutively active CD40 receptor and promotes the transformation of immortalized rodent fibroblasts in vitro and their oncogenicity in vivo. The observed effects of aberrant CD40 activation on cell transformation are largely diminished upon suppression of the oncogenic NF-kappaB signalling pathway. Taken together, our results suggest a role for the constitutive engagement of the CD40L/CD40/NF-kappaB activation pathway in cell transformation and neoplastic growth. Strategies that neutralize this pathway may therefore be useful in cancer treatment and prevention.

Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A.

Control of translation initiation is one means by which cells regulate growth and proliferation, with components of the protein-synthesizing machinery having oncogenic potential. Expression of latency protein LMP2A by the human tumor virus Epstein-Barr virus (EBV) activates phosphatidylinositol 3-kinase/Akt located upstream of an essential mediator of growth signals, mTOR (mammalian target of rapamycin). We show that mTOR is activated by expression of LMP2A in carcinoma cells, leading to wortmannin- and rapamycin-sensitive inhibition of the negative regulator of translation, eukaryotic initiation factor 4E-binding protein 1, and increased c-Myc protein translation. Intervention by this DNA tumor virus in cellular translational controls is likely to be an integral component of EBV tumorigenesis.

Expression of tumor necrosis factor receptor-associated factor 1 in nasopharyngeal carcinoma: possible upregulation by Epstein-Barr virus latent membrane protein 1.

EBV infection is associated with virtually all cases of undifferentiated NPC, and the EBV-encoded LMP1 is expressed in a proportion of cases. LMP1 has transforming functions similar to members of the TNF receptor family and activates intracellular signaling cascades through interaction with TRAFs. In B cells, expression of TRAF1 is in turn upregulated by LMP1. LMP1 signaling in epithelial cells may be affected by the presence or absence of TRAF1. By immunohistochemistry, we detected TRAF1 expression in 17 of 42 (40%) EBV+ undifferentiated NPCs. All 7 LMP1+ NPC biopsies were also TRAF1+. Using an RNAse protection assay, high-level TRAF1 expression was detected in an LMP1-expressing NPC-derived cell line (C15) and expression was weaker in 2 LMP1- cell lines (C17, C19). Finally, LMP1 upregulated TRAF1 expression in an EBV- keratinocyte cell line. Our results demonstrate that TRAF1 is expressed in NPC tumor cells in vivo and suggest that TRAF1 expression may be upregulated by LMP1 in NPC. An antiapoptotic function has been proposed for TRAF1, and this may be relevant for the pathogenesis of NPC.

Testicular cancer: seek advice early.

Men's partners are often the first to notice a common sign of testicular cancer -- painless swelling or abnormality of the testis or scrotum. The man should consult his GP straightaway, as early diagnosis is critical.

Tumour necrosis factor-alpha in Barrett's oesophagus: a potential novel mechanism of action.

Barrett's metaplasia (BM) is an early lesion in the progression from oesophageal inflammation through dysplasia to the development of Barrett's adenocarcinoma (BA). Previous work indicates that BM and BA are associated with reduced E-cadherin expression and increased cytoplasmic/nuclear pools of its associated protein beta-catenin. beta-catenin participates in Wnt signalling and activates oncogene transcription by complexing with T-cells factors (TCF). One such oncogene is c-myc. We have previously shown that TNF-alpha can down-regulate E-cadherin expression. Here, we assess TNF-alpha expression in Barrett's metaplasia and examine if TNF-alpha can promote beta-catenin mediated transcription of oncogenes in a gastrointestinal model system. Employing immunohistochemistry and Western blot analysis of oesophageal tissue, epithelial expression of TNF-alpha increases with progression along the metaplasia-dysplasia-carcinoma sequence (P<0.001). beta-catenin mediated transcription was then assessed in TNF-alpha stimulated cell lines using the TOPFLASH reporter system whilst c-myc expression was assessed by real time PCR. In a columnar intestinal cell model, TNF-alpha induces c-myc expression which is induced via beta-catenin mediated transcription (P<0.05). This beta-catenin mediated transcription is independent of NF-kappaB activation. Thus, TNF-alpha is up-regulated in the progression of Barrett's oesophagus and beta-catenin mediated transcription of c-myc is a novel pathway whereby elevated levels of TNF-alpha may lead to oncogene transcription and altered biology in gastrointestinal epithelia and metaplasia.