RESUMO
BACKGROUND: The patch test is an essential procedure for the investigation of aetiologic diagnosis of allergic contact dermatitis, although it is not yet able to fully reproduce the events of the initial site of contact with the allergen. OBJECTIVES: The aims of the present study are (i) to assess whether removal of the superficial corneous layer results in test positivity differences vs. the traditional technique, (ii) to assess the probable and/or possible and past and/or present sensitivity and relevance for each method, and (iii) to compare specific relevance of nickel sulphate for each method. RESULTS: Concordance of positive reactions was 75.9% (66 of 87), with 21.8% (19 of 87) positivity results on the abraded side only and 2.3% (2 of 87) on the unabraded side (P < 0.05). Concordance of the substances with probable and/or possible and past and/or present relevance was 77.3% (58 of 75) for the abraded side and 21.3% (16 of 75) and 1.3% (1 of 75) for the unabraded side (P < 0.05). Analysis of isolated relevance for nickel sulphate showed 95.6% (22 of 23) concordance. CONCLUSIONS: (i) We found a greater number of positive substances on the abraded side, and when only the 2 + and 3 + reactions were considered, greater relative discordance was also observed; (ii) relevance analysis revealed a statistically significant difference between the two methods; (iii) differences in nickel sulphate test positivity and relevance for the two methods did not reach statistical significance.
Assuntos
Dermatite de Contato/diagnóstico , Testes do Emplastro/métodos , Adolescente , Adulto , Idoso , Distribuição de Qui-Quadrado , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade e Especificidade , Fita CirúrgicaRESUMO
We report a case of acute generalized exanthematous pustulosis (AGEP) in a 64-year-old woman, associated with the use of bamifylline. To the best of our knowledge there have been no previous reports of AGEP induced by the ingestion of bamifylline in the medical literature. We, therefore, add this drug to the list of causes for AGEP.
Assuntos
Broncodilatadores/efeitos adversos , Toxidermias/etiologia , Exantema/induzido quimicamente , Dermatopatias Vesiculobolhosas/induzido quimicamente , Teofilina/análogos & derivados , Teofilina/efeitos adversos , Asma/tratamento farmacológico , Broncodilatadores/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , Teofilina/uso terapêuticoRESUMO
Chronic urticaria and concurrent angioedema are disappointing problems for both physicians and patients. The disease can result from multiple causes and probably does not have a single etiology. Several factors have been identified that appear to be important in the pathogenesis of individual cases, some drugs, food additives, physical factors and internal diseases. In some cases no pathogenesis are identified and those cases are classified as idiopathic. In recent years several articles has emphasized autoimmunity and infections due to Helicobacter pylori. Our article reviewed the etiology of chronic urticaria at current concepts.
Assuntos
Urticária/etiologia , Angioedema/diagnóstico , Angioedema/etiologia , Angioedema/imunologia , Autoimunidade , Infecções Bacterianas/complicações , Doença Crônica , Humanos , Doenças Parasitárias/complicações , Urticária/diagnóstico , Urticária/imunologia , Viroses/complicaçõesRESUMO
Bioassay-directed fractionation of Desmodium canum resulted in the isolation and characterization of three antimicrobial isoflavonones. These compounds, namely, desmodianones A, B and C, were assigned the structures 5,7,2'-trihydroxy-6,6"-dimethyl-6"-(4-methylpent-3- enyl)pyrano(2",3";4',5')isoflavanone, 5,2',4'-trihydroxy-7-methoxy-6-methyl-8-(3-methylbut-2-enyl)-is oflavanone, and 5,7,2',4'-tetrahydroxy-6-methyl-5'-(3,7-dimethylocta-2,6-dienyl )-isoflavanone, respectively.
Assuntos
Anti-Infecciosos/isolamento & purificação , Anti-Infecciosos/farmacologia , Isoflavonas/isolamento & purificação , Isoflavonas/farmacologia , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Plantas Medicinais/química , Fracionamento Químico , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Raízes de Plantas/químicaAssuntos
Antibióticos Antineoplásicos/análise , Streptomyces/análise , Troleandomicina/análise , Antibióticos Antineoplásicos/uso terapêutico , Espectroscopia de Ressonância Magnética , Naftacenos/análise , Naftacenos/uso terapêutico , Neoplasias Experimentais/tratamento farmacológico , Troleandomicina/uso terapêuticoRESUMO
Bisnordihydrotoxiferine has been isolated as the major alkaloid from the root bark of Strychnos trinervis. This compound shows a wide antimicrobial spectrum against gram-positive, gram-negative and acid-fast microorganisms, filamentous and yeast-like fungi and also phytopathogenic microorganisms. Preliminary studies also reveal some cytotoxic activity in KB cells which was confirmed by tests against sarcoma 180 tumors.
Assuntos
Alcaloides/análise , Plantas Medicinais/análise , Toxiferina/análogos & derivados , Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Antibacterianos , Anti-Infecciosos/farmacologia , Antineoplásicos Fitogênicos/farmacologia , Bactérias/efeitos dos fármacos , Células Cultivadas , Fungos/efeitos dos fármacos , Humanos , Testes de Sensibilidade Microbiana , Toxiferina/isolamento & purificação , Toxiferina/farmacologiaRESUMO
Brazil has a long tradition of popular medicine in its different geographical areas (Amazonas, highlands and coast) and different cultural groups (Aruak, Tupi, Guarani). Recently the documentation of plants used in traditional medicine has been organized in Maceió, Brazil, but pharmacological investigations of these plants have been limited so far. High-level chemical research on natural products is developing quickly in the Federal Universities, but it is only seldom centred on medicinal plants. An exception is constituted by the Institute of Antibiotics of the University of Pernambuco where a multi-year programme on the chemistry of plants with pharmacological properties has been developed. Much interest is being shown in these studies, and the results should be coordinated and developed further.
Assuntos
Plantas Medicinais , Academias e Institutos , Brasil , Humanos , PesquisaRESUMO
A number of synthetic analogs of the prenylated and chromene chalcones isolated from lonchocarpus neuroscapha (Leguminosae) were obtained by condensation of prenylated acetophenones with substituted benzaldehydes. The antibacterial activity of these products was studied and correlated with their structure.
Assuntos
Chalcona/análogos & derivados , Propiofenonas/análogos & derivados , Acetofenonas/farmacologia , Bactérias/efeitos dos fármacos , Benzaldeídos/farmacologia , Chalcona/síntese química , Chalcona/farmacologia , Testes de Sensibilidade MicrobianaRESUMO
The isolation of eight prenylated chalcones (cordoin, isocordoin, psi-isocordoin, derricin, lonchocarpin, 4-hydroxyderricin, 4-hydroxylonchocarpin, 4-hydroxyisocordoin) and of the flavanone and dihydrochalcone corresponding to cordoin is described. These substances are biogenetically correlated. The structures of the above mentioned substances were established through the examination and comparison of spectral data (U.V., I.R., N.M.R., M.S.) and of the chemical behaviour. Particular interest is shown by psi-isocordoin and 4-hydroxy derivatives. The latter and 4-hydroxyderricin in particular show also a marked inhibition on the growth of gram-positive bacteria.
Assuntos
Chalcona , Propiofenonas , Alcenos/isolamento & purificação , Bactérias/efeitos dos fármacos , Brasil , Chalcona/análogos & derivados , Chalcona/isolamento & purificação , Chalcona/farmacologia , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Plantas MedicinaisRESUMO
The authors present the first observations on the isolation of two quinonoid compounds from Hyptis fructicosa Salzm ex Benth; Labiatae. The referred naturally compounds present antimicrobial and antineoplastic activity against Gram-positive microrganisms and mouse Erlich carcionama, respectivelly.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Quinonas/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/uso terapêutico , Bactérias/efeitos dos fármacos , Carcinoma de Ehrlich/tratamento farmacológico , Avaliação de Medicamentos , Resistência Microbiana a Medicamentos , Métodos , Camundongos , Testes de Sensibilidade Microbiana , Transplante de Neoplasias , Neoplasias Experimentais/tratamento farmacológico , Fitoterapia , Extratos Vegetais/uso terapêutico , Quinonas/uso terapêutico , Sarcoma 180/tratamento farmacológicoRESUMO
In the course of our program on the antimicrobial and antineoplastic substances from higher plants we have studied many flavonoid compounds isolated from root back of Lonchocarpus neuroscapha Benth. In the present paper a slight effect on sarcoma 180 and Ehrlich carcinoma of cordoin, 4-hydroxy-cordoin and 4-hydroxy-derricin, as well as the only observed effect of derricin on sarcoma 180 were observed. The antimicrobial action of four prenylated chalcones, i.e. 4-hydroxy-derricin, 4-hydroxy-lonchocarpin, 4-hydroxy-cordoin and 4-hydroxy-isocordoin is reported.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Chalcona/isolamento & purificação , Propiofenonas/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/farmacologia , Bactérias/efeitos dos fármacos , Carcinoma de Ehrlich/tratamento farmacológico , Chalcona/análogos & derivados , Chalcona/farmacologia , Resistência Microbiana a Medicamentos , Dose Letal Mediana , Camundongos , Testes de Sensibilidade Microbiana , Extratos Vegetais , Sarcoma 180/tratamento farmacológicoRESUMO
In this paper the authors present the first report concerning the biological effects of a diterpene isolated from Croton aff. argyrophylloides Muell. Arg (Euphorbiaceae). Some biological and physiochemical properties of the antibiotic, named argyrophillic acid, were appreciated in comparison with those presented by cunabic acid, an antibiotic isolated from Icthyothere cunabi. The authors still show the microbial action of the abietic acid and confront it with that of the argyrophilic acid, the new antibiotic here reported.