Assuntos
Arterite de Células Gigantes/complicações , Poliarterite Nodosa/complicações , Pele/patologia , Idoso , Biópsia por Agulha , Feminino , Arterite de Células Gigantes/patologia , Humanos , Livedo Reticular/etiologia , Livedo Reticular/patologia , Necrose/patologia , Poliarterite Nodosa/patologiaRESUMO
Children with oedematous malnutrition, known as kwashiorkor, may develop a characteristic skin lesion, named 'Dermatosis of Kwashiorkor' (DoK). Only a few studies have been concerned with this condition, and the reason for the development of DoK remains unexplained. This study review the existing studies concerning DoK, including its clinical manifestations, histopathology, suggested pathophysiology, current treatment and prognosis for children of the age of 6 months to 5 years. Standardized clinical studies are needed to further understand the implications of DoK. Such studies would suffer from the lack of consistency concerning the terminology and scoring of the lesions in DoK. We therefore stress the need for a standardized scoring of the degree of DoK. This would facilitate valid and comparable studies and the development of better treatment for this vulnerable group of patients.
Assuntos
Kwashiorkor/complicações , Dermatopatias/complicações , Criança , Humanos , Kwashiorkor/dietoterapia , Prognóstico , Dermatopatias/dietoterapia , Dermatopatias/terapiaRESUMO
Atopic dermatitis (AD) is histologically characterized by lymphocytic infiltration of the skin and quantitative assessment is required. This study introduces stereological techniques to quantify the number of lymphocytes in skin biopsies. Four-millimetre punch biopsies were taken from skin with active eczema in 8 adults with AD and from clinically normal skin from 4 of the patients. Five persons without allergy or skin disease served as controls. The mean number of lymphocytes in 4-mm skin biopsies was 469,000 and 124,000 in active eczema and in clinically normal skin, respectively. Compared with controls, the number of lymphocytes in biopsies increased by a factor of 6.8 in active eczema and a factor of 1.8 in clinically normal skin. If 20% of skin is affected by eczema the total number of lymphocytes located in the affected skin can be estimated to 1.27 x 10(10). A patient with clinically moderate AD has a considerable number of lymphocytes in the skin.
Assuntos
Dermatite Atópica/patologia , Linfócitos , Pele/patologia , Adulto , Biópsia , Estudos de Casos e Controles , Dermatite Atópica/imunologia , Feminino , Humanos , Imunoglobulina E/sangue , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Pele/imunologiaRESUMO
We report a case of skin affection on the abdomen in a 75 year-old woman with an ileostomy. The lesion developed during a period of two years on a site distant from the patient's present ostomy. However, it was located on the site of a former ileostomy removed 25 years ago. The lesion was due to proliferation of remaining gut mucosa.