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AIM: The present study aimed to investigate the effect of the presence of polyposis in sporadic early-onset colorectal cancer (EOCRC) on clinicopathological and oncological outcomes. METHODS: The retrospective study included patients with sporadic colorectal cancer aged 16 to 50 years who underwent curative resection at the general surgery clinics in two healthcare centers between 2013 and 2019. Patients were divided into two groups: polyposis and nonpolyposis. Clinicopathological characteristics and oncological outcomes were compared between the two groups. RESULTS: A total of 127 patients were included, of whom 60.6% were men. There were 25 (19.68%) patients in the polyposis group and 102 (80.31%) patients in the nonpolyposis group. Seventy-one (69.6%) of the nonpolyposis group and 23 (92.0%) of the polyposis group had adenocarcinoma histological types. The total number of patients with mucinous tumor and signet ring cell carcinoma in the nonpolyposis and polyposis groups was 31 (30.4%) and 2 (8.0%), respectively (p = 0.042). Five-year overall survival (OS) was 60 and 72% in the nonpolyposis and polyposis groups, respectively, and no significant difference was found (p = 0.332). In univariate analysis, American Joint Committee on Cancer (AJCC) tumor stage (pT) ≥3-4, lymph node positivity, presence of mucinous tumor and signet ring cell carcinoma, lymphovascular invasion, and advanced tumor-lymph nodesmetastasis (TNM) stage (III-IV) were found to be significant negative prognostic factors for OS, whereas none of these parameters were found to be prognostic factors in multivariate analysis. The presence of polyposis was not a significant factor on both univariate and multivariate analyses. CONCLUSION: Although the sporadic EOCRC cases developing on the basis of polyposis can have slightly better oncological outcomes, these outcomes are mostly similar to those of cases with nonpolyposis. HOW TO CITE THIS ARTICLE: Aday U, Kafadar MT, Oguz A, et al. Polyposis and Oncologic Outcomes in Young-onset Sporadic Colorectal Cancer. Euroasian J Hepato-Gastroenterol 2021;11(1):6-10.
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OBJECTIVE: Although the sale of electronic (e)-cigarettes and "I Quit Ordinary Smoking" (IQOS) is completely prohibited in Turkey, it is observed that tobacco products are sold on the internet. MATERIAL AND METHODS: This descriptive study was conducted between February 11 and 15, 2019, using three search engines (Google, Yandex, and Yaani) in Turkey. All combinations obtained with the keywords (wrapping tobacco, cigarette, hookah, pigtail, cigar, pipe, e-cigarette, snuff, and IQOS) and appendices (sale, price, and shipping) were searched; 2,160 links were scanned. The contents obtained from 130 different URLs were evaluated. RESULTS: The most sold product was e-cigarettes (41.2%) and the least sold one was cigarettes (2.5%). Websites contained 500 phone numbers (79%), live support (32.8%), e-mail addresses (67.2%), and postal addresses (42.9%) for communication. Approximately half of the sites had routing tabs to social media. These websites offered some payment facilities (credit card/debit card, 64.7%; money order/electronic funds transfer (EFT), 37.8%; payment at the door, 54.6%) and contained encouraging texts (61.3%) and misinformation (42.9%). More number of websites selling e-cigarettes or IQOS had the campaign sales (89.3% vs 63.6%; p=0.001), possibility of shipping (98.7% vs 86.4%; p<0.05), and false information about the harmlessness of the tobacco products (61.3% vs 11.4%; p<0.001) compared with websites selling other products. CONCLUSION: This is the first study to show that the tobacco industry is breaking the laws, and the websites which sell tobacco products are easily accessible to the internet users. It is necessary to strengthen the electronic commerce monitoring and control in Turkey.