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1.
Macromol Biosci ; 21(1): e2000234, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33043585

RESUMO

The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellular regeneration and functional recovery. Promising SCI treatments use biomaterial scaffolds, which provide bioactive cues to the cells in order to trigger neural regeneration in the spinal cord. In this work, the use of peptide nanofibers is demonstrated, presenting protein binding and cellular adhesion epitopes in a rat model of SCI. The self-assembling peptide molecules are designed to form nanofibers, which display heparan sulfate mimetic and laminin mimetic epitopes to the cells in the spinal cord. These neuroactive nanofibers are found to support adhesion and viability of dorsal root ganglion neurons as well as neurite outgrowth in vitro and enhance tissue integrity after 6 weeks of injury in vivo. Treatment with the peptide nanofiber scaffolds also show significant behavioral improvement. These results demonstrate that it is possible to facilitate regeneration especially in the white matter of the spinal cord, which is usually damaged during the accidents using bioactive 3D nanostructures displaying high densities of laminin and heparan sulfate-mimetic epitopes on their surfaces.


Assuntos
Nanofibras/química , Peptídeos/farmacologia , Traumatismos da Medula Espinal/tratamento farmacológico , Medula Espinal/efeitos dos fármacos , Substância Branca/crescimento & desenvolvimento , Animais , Adesão Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Modelos Animais de Doenças , Epitopos/efeitos dos fármacos , Gânglios Espinais/efeitos dos fármacos , Humanos , Regeneração Nervosa/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Peptídeos/química , Ligação Proteica/efeitos dos fármacos , Ratos , Medula Espinal/crescimento & desenvolvimento , Medula Espinal/patologia , Traumatismos da Medula Espinal/patologia , Substância Branca/efeitos dos fármacos
2.
World Neurosurg ; 117: e316-e322, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29906582

RESUMO

OBJECTIVE: To examine the surgical results of unilateral lumbar discectomy in patients with bilateral leg pain and discuss short- and long-term outcomes within the limits of lumbar decompression. METHODS: We analyzed 60 patients with unilateral disc herniation who underwent unilateral lumbar discectomy and hemipartial laminectomy between 2014 and 2017. Group 1 (30 patients) had bilateral leg pain and unilateral lumbar disc herniation. Pain lateralization was determined radiologically. Group 2 (30 patients) had unilateral leg pain and unilateral lumbar disc herniation. Pain scores were preoperatively evaluated with visual analog scale (VAS) for both legs and Oswestry Disability Index (ODI) for overall life quality. In both groups, surgery was performed on the ipsilateral side of the herniated disc. Scores were repeated on postoperative day 1 and 1, 3, 6, 12, and 24 months later. VAS score differences for pain lateralization and disc levels were compared in group 1. ODI score differences were compared between both groups. Results were statistically analyzed. RESULTS: VAS score differences were statistically significant at all follow-up time points in patients with ipsilateral and contralateral pain. VAS score differences between L4-L5 and L5-S1 level discopathies were statistically insignificant for all time points in both groups. All postoperative ODI score decreases for all time points were statistically significant (P < 0.001) for both groups, whereas the differences between groups 1 and 2 were statistically insignificant. CONCLUSIONS: Conventional lumbar disc surgery alone is sufficient for the ipsilateral side of radiologically demonstrated disc herniation in patients with bilateral leg pain.


Assuntos
Deslocamento do Disco Intervertebral/cirurgia , Dor Musculoesquelética/cirurgia , Adulto , Idoso , Discotomia/métodos , Feminino , Humanos , Laminectomia/métodos , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Dor Musculoesquelética/etiologia , Estudos Prospectivos , Resultado do Tratamento
3.
World Neurosurg ; 114: e247-e253, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29530700

RESUMO

OBJECTIVE: The pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have been shown in experimental studies. This study aimed to investigate the effect of riluzole on neural regeneration in a rat SCI model. METHODS: Thirty-two rats were divided into 8 groups, with 4 rats in each group. Hemisection method was performed after T7-T9 laminectomy. Rats were intraperitoneally aministered with riluzole (6 mg/kg). Locomotor recovery of the rats was assessed at 1 day, and 1, 2, 3, and 4 weeks after the 21-point Basso, Beattie, and Bresnahan test. Subsequently, the spinal cords of the rats were scored according to a semiquantitative grading system using a light microscope, and the numbers of myelinated axons, neurons, and glial cells were calculated. RESULTS: Basso, Beattie, and Bresnahan test changes were statistically significant when groups 4-6 and 8 were compared with the other groups (P < 0.05, P < 0.00625). The results of the numbers of neurons, glial cells, and myelinated axons were statistically significant. Especially group 8, in which riluzole was administered 5 days before injury, more positive clinical and histopathologic results were obtained. CONCLUSIONS: Riluzole treatment is more effective when provided before injury. Riluzole may contribute to functional recovery when used in the preoperative period in patients who are at a high risk for permanent neurologic deficit.


Assuntos
Regeneração Nervosa/efeitos dos fármacos , Fármacos Neuroprotetores/uso terapêutico , Riluzol/uso terapêutico , Traumatismos da Medula Espinal/prevenção & controle , Animais , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Esquema de Medicação , Laminectomia/efeitos adversos , Locomoção/efeitos dos fármacos , Masculino , Bainha de Mielina/efeitos dos fármacos , Bainha de Mielina/fisiologia , Ratos , Ratos Wistar , Recuperação de Função Fisiológica , Índice de Gravidade de Doença
4.
Turk Neurosurg ; 26(4): 643-5, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27400114

RESUMO

Fahr's Syndrome is characterized by the presence of intracerebral, bilateral and symmetrical calcifications located in bilateral basal ganglia, thalamus, and cerebellum. The etiology is not exactly known. The authors reported a very rare case who had Fahr's Syndrome and intracerebral aneurysms simultaneously. The patient was female and presented with headache. Her examinations revealed aneurysms on the middle cerebral artery, internal carotid artery and ophthalmic artery. That is the first case reported in the literature having multiple intracranial aneurysms and Fahr's Syndrome together.


Assuntos
Doenças dos Gânglios da Base/complicações , Doenças dos Gânglios da Base/diagnóstico por imagem , Calcinose/complicações , Calcinose/diagnóstico por imagem , Aneurisma Intracraniano/complicações , Aneurisma Intracraniano/diagnóstico por imagem , Doenças Neurodegenerativas/complicações , Doenças Neurodegenerativas/diagnóstico por imagem , Adulto , Artéria Carótida Interna/diagnóstico por imagem , Feminino , Humanos , Artéria Cerebral Média/diagnóstico por imagem
5.
Turk Neurosurg ; 26(4): 643-645, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27306481

RESUMO

Fahr's Syndrome is characterized by the presence of intracerebral, bilateral and symmetrical calcifications located in bilateral basal ganglia, thalamus, and cerebellum. The etiology is not exactly known. The authors reported a very rare case who had Fahr's Syndrome and intracerebral aneurysms simultaneously. The patient was female and presented with headache. Her examinations revealed aneurysms on the middle cerebral artery, internal carotid artery and ophthalmic artery. That is the first case reported in the literature having multiple intracranial aneurysms and Fahr's Syndrome together.


Assuntos
Doenças dos Gânglios da Base/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Artéria Carótida Interna/diagnóstico por imagem , Aneurisma Intracraniano/diagnóstico por imagem , Artéria Cerebral Média/diagnóstico por imagem , Artéria Oftálmica/diagnóstico por imagem , Adulto , Angiografia Digital , Doenças dos Gânglios da Base/complicações , Calcinose/complicações , Angiografia Cerebral , Feminino , Humanos , Aneurisma Intracraniano/complicações , Imageamento por Ressonância Magnética , Síndrome
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