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1.
Org Lett ; 23(12): 4548-4552, 2021 06 18.
Artigo em Inglês | MEDLINE | ID: mdl-34053223

RESUMO

Phosphines were previously unusable as Pummerer-type nucleophiles due to competing redox chemistry with sulfoxides. Here we circumvent this problem to achieve a formal phosphine Pummerer reaction that offers thioalkyl phosphonium salts that, in turn, give rise to diverse vinyl sulfides via Wittig olefinations. Thirty vinyl sulfides are thus prepared from (alkylthioalkyl)triphenyl phosphonium salts and aldehydes. The hydrolysis of these vinyl sulfides offers an efficient and versatile two-step one-carbon homologation of aldehydes to ketones.


Assuntos
Aldeídos/química , Cetonas/síntese química , Fosfinas/química , Carbono/química , Catálise , Estrutura Molecular , Oxirredução , Sais , Sulfetos/química , Sulfóxidos/química
2.
Angew Chem Int Ed Engl ; 57(13): 3377-3380, 2018 03 19.
Artigo em Inglês | MEDLINE | ID: mdl-29479783

RESUMO

Fluorescent dyes have been widely utilized as chemical sensors and in photodynamic therapy, but exploitation of their redox-active nature in chemical reactions has remained mostly unexplored. This report describes the isolation of a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based radical. The redox-active nature of the BODIPY compound can be utilized in combination with a guanidine center, the basicity of which can be manipulated by greater than 14 pKa units, to promote the conversion of protons and electrons into H-atoms for transfer to substrate molecules.

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