[Radiochemotherapy for the treatment ofmuscle invasive bladder tumors in a west african radiotherapy service]. / Radiochimiotherapie pour le traitement des tumeurs de vessie infiltrant lemuscle dans un service de radiotherapie ouest africaine.

OBJECTIF: The aim of this study was to describe the results of radiochemotherapy in patients after transurethral resection of muscle invasive bladder tumors. MATERIAL AND METHODS: A retrospective study from May 2014 to May 2016 in the radiotherapy department of the Mali Hospital. Have been included, all patients with bladder cancer infiltrating the muscle. Secondary cancers of the bladder and metastatic forms have been excluded from our study. Transurethral resection of bladder was performed. Neoadjuvant chemotherapy with paclitaxel- carboplatin was administered every three weeks in all patients, then external phototherapy 6 MV at a dose of 66 Gy due to 2 Gy of 5 sessions per week 6MV photon of external beam radiotherapy at a dose of 66 Gy due to 2 Gy of 5 sessions per week associated with concomitant cisplatin at dose of 40mg / m2 / week. RESULTS: Eight patients were included in ourstudy. The average age of 53.75 ± 14.84 years. The male sex was predominant 87.5% (n = 7). The history of chronic smoking wasfound in four patients. The main carcinogenic risk factor identified in our patients was urogenital bilharzia (6 cases / 8).The histological type found was urothelial carcinomain 12.5% (n = 1) and invasive squamous cell carcinomain 87.5% (n = 7). Transurethral resection of the tumor was performed in 62.5% (n = 5). Endoscopic biopsy was performed in 37.5% (n = 3). The tumor was classified pT2N0M0 in 50% (n = 4), pT3aN0M0 in 37.5% (n = 3) and pT3bN0M0 in 12.5% (n = 1). Neoadjuvant chemotherapy with paclitaxel - carboplatin every three weeks was administered to all patients. The results of radiochemotherapy (see Table: evolution). CONCLUSION: Concomitant radiochemotherapy is a conservative curative treatment that can be proposed as a replacement for cystectomy, for non-metastatic infiltrating tumors after the most complete endoscopic resection.

OBJECTIF: Le but de cette étude était de décrire les résultats d'une radiochimiothérapie chez les patients après résection transurétrale des tumeurs de vessie infiltrant le muscle. MATÉRIEL ET MÉTHODES: Une étude rétrospective allant de mai 2014 à mai 2016 au service de radiothérapie de l'hôpital du Mali. Ont été inclus, tous les patients présentant un cancer de vessie infiltrant le muscle. Les cancers secondaires de la vessie ainsi que les formes métastatiques ont été exclus de notre étude. La résection transurétrale de vessie a été réalisée. La chimiothérapie néoadjuvante à base de paclitaxel ­ carboplatine a été administrée toutes les trois semaines. La radiothérapie externe au photon 6MV à la dose de 66 Gy en raison de 2 Gy de 5 séances par semaine associée à la chimiothérapie concomitante à base de cisplatine (CDDP) 40mg/m2/semaine a été réalisée. RÉSULTATS: Au total huit patients ont été inclus dans notre étude. L'âge moyen de 53,75±14,84 ans. Le sexe masculin était prédominant 87.5% (n=7). L'antécédent de tabagisme chronique était retrouvé chez quatre patients. Le principal facteur de risque cancérigène identifié chez nos patients était la bilharziose urogénitale (6cas/8). Le type histologique retrouvé était le carcinome urothelial dans 12.5% (n=1) et le carcinome épidermoïde infiltrant dans 87.5% (n=7). La résection transurétrale de la tumeur a été réalisée dans 62.5% (n=5). La biopsie par voie endoscopique été réalisée dans 37.5% (n=3). La tumeur été classée pT2N0M0 dans 50% (n= 4), pT3aN0M0 dans 37.5% (n=3) et pT3bN0M0 dans 12.5% (n= 1). La chimiothérapie néoadjuvante à base de paclitaxel ­ carboplatine chaque trois semaines a été administrée chez tous les malades.Les résultats de la radiochimiothérapie (cf. Tableau: évolution). CONCLUSION: La radiochimiothérapie concomitante est un traitement curatif conservateur qui peut être proposée en remplacement à la cystectomie pour les tumeurs infiltrantes non métastatiques après une résection endoscopique la plus complète possible.

[Ct scan diagnosis of polyostotic fibrous dysplasia with maxillofacial dysmorphia: a case report]. / Diagnostic tomodensitometrique d'une dysplasie fibreuse polyostotique avec dysmorphie maxillo-faciale : a propos d'un cas.

We report a rare case of polyostotic fibrous dysplasia with maxillofacial dysmorphia diagnosed in the radiology department at Hopital Sominé Dolo of Mopti. The aim was to describe the role of medical imaging including the CT scan in its diagnosis. He was a 42-year-old man of rural origin with poor socio-economic conditions. He was sent to us for a craniofacial CT scan for assessment of a maxillofacial mass. This CT scan showed a thickening of the diploid of the vault and the cranial base with osteocondensation and osteolytic lesions at the maxillofacial level. An extension assessment showed polyostotic involvement. His diagnosis is based on medical imaging and in particular CT scan. Three types of radiological aspects are evocative: a homogeneous or heterogeneous clarity, a smoke-like appearance and a slightly condensed appearance. Complications observed were deformities, fracture of the femoral neck and aesthetic damage.

Nous rapportons un cas rare de dysplasie fibreuse polyostotique avec dysmorphie maxillo-faciale diagnostiqué au service de radiologie à l'hôpital Sominé Dolo de Mopti. Le but était de décrire le rôle de l'imagerie médicale notamment le scanner dans son diagnostic. Il s'agissait d'un homme âgé de 42 ans, de provenance rurale avec des conditions socio-économiques défavorables. Il nous a été adressé pour un scanner crâniofacial pour bilan d'une masse maxillo-faciale. Cette exploration scanographique avait objectivé un épaississement du diploé de la voûte et de la base crânienne avec ostéocondensation et des lésions ostéolytiques soufflantes au niveau maxillo-facial. Un bilan d'extension a objectivé une atteinte polyostotique. Son diagnostic repose sur l'imagerie médicale et en particulier la tomodensitométrie. Trois types d'aspects radiologiques sont évocateurs: une clarté homogène ou hétérogène, un aspect en volutes de fumée et un aspect légèrement condensé. Les complications observées étaient les déformations, la fracture du col fémoral et le préjudice esthétique.

[Spontaneous triple pregnancy on bicicatricial uterus in the referral health center of commune II of Bamako, Mali]. / Grossesse triple spontanee sur uterus bicicatriciel au centre de sante de reference de la commune II de Bamako, Mali.

The trimellar pregnancy on bicicatricial uterus is a rare situation. It can be associated with many maternal-fetal complications. Given these risks, some teams opt for an embryonic reduction. We report a case of spontaneous trimellar pregnancy on bicicatricial uterus. This was a 38 year-old patient, third pregnancy, second birth, 2 alive with a history of 2 caesareans. The evolution of the pregnancy was marked by a urinary tract infection at 34 weeks of gestation. The caesarean section performed at 36 weeks of gestation allowed the birth of 3 newborns, 2 of which were females in 2000 and 1900 grams, and one male weighing 2400 grams. The postpartum was marked by a rapidly resolved eclampsia crisis.

La survenue d'une grossesse triméllaire sur un utérus bicicatriciel est une situation rare. Elle peut être associée à de nombreuses complications materno-fœtales. Compte tenu de ces risques, certaines équipes optent pour une réduction embryonnaire. Nous rapportons un cas de grossesse triméllaire spontanée sur utérus bicicatriciel. Il s'agissait d'une patiente de 38 ans 3è geste, 2è pare avec 2 enfants vivants, ayant un antécédent de 2 césariennes. L'évolution de la grossesse a été marquée par une infection urinaire à 34 SA. La césarienne pratiquée à 36 SA a permit la naissance de 3 nouveaunés dont 2 de sexes féminins de 2000 et 1900g et un de sexe masculin pesant 2400g. Les suites de couches ont été marquées par une crise d'éclampsie rapidement résolue.

[Materno-Fetal Prognosis Of Anemia In Bougouni]. / Pronostic Materno-Fœtal De L'Anemie A Bougouni.

GOAL: The goal was to assess the maternal-fetal prognosis of anemia in pregnant women in the Bougouni reference health center. METHODS: We carried out a prospective descriptive and analytical cross-sectional study from January 1 to December 31, 2013 at the Bougouni reference health center. It covered all pregnant women with a hemoglobin level below 11g/dl regardless of the outcome of the pregnancy. RESULTS: The prevalence of anemia in pregnant women was 33.2%. They were women married to peasants in 88.6% of cases, unschooled in 93.2% of cases, having not done antenal care in 56.8% of cases. Malaria was the most common etiology in 75% of cases. Anemia was severe in 61.4% of cases. The maternal-fetal prognosis was dominated by 3.3% of maternal death, 12.5% of abortion, 7.6% of prematurity and 6.8% of fetal death in utero. CONCLUSION: Anemia in pregnant women is the source of many maternal-fetal complications.

BUT: Le but était d'évaluer le pronostic materno-fœtal de l'anémie chez la femme enceinte dans le centre de santé de référence de Bougouni. MÉTHODES: Nous avons réalisé une étude transversale prospective descriptive et analytique du 1er janvier au 31 décembre 2013 au centre de santé de référence de Bougouni. Elle a porté sur toutes les femmes enceintes ayant un taux d'hémoglobine inférieur à 11g/dl quelle que soit l'issue de la grossesse. RÉSULTATS: La prévalence de l'anémie chez les femmes enceintes a été de 33,2%. Il s'agissait de femmes mariées à des paysans dans 88,6% des cas, analphabètes dans 93,2% des cas, n'ayant pas fait de consultations prénatales dans 56,8% des cas. Le paludisme a été l'étiologie la plus fréquente dans 75% des cas. L'anémie était sévère dans 61,4% des cas. Le pronostic materno-fœtal a été dominé par 3,3% de décès maternel, 12,5% d'avortement, 7,6% de prématurité et 6,8% de mort fœtale in utéro. CONCLUSION: L'anémie chez la femme enceinte est pourvoyeuse de nombreuses complications materno-fœtales.

[Pregnancy And Delivery In The Large Multiparous In The Reference Health Center Of Commune II Of Bamako, Mali]. / Grossesse Et Accouchement Chez La Grande Multipare Au Centre De Sante De Reference De La Commune II De Bamako, Mali.

AIM: The aim was to compare the maternal-fetal prognosis of pregnancies in large multiparous with that of other parities. MATERIALS AND METHODS: We conducted a case-control study from March 1st, 2014 to February 1st, 2015. It concerned all parturients admitted in our service during the study period. We have chosen 1 case for 2 witnesses. All the large multiparous were included as cases and as witnesses the primiparous, the pauciparous and the multiparous who gave birth just before and after the case. The statistical test was the Chi2 with a significance level at 5%. RESULTS: The frequency of pregnancy in the large multiparous was 4.93%. They were housewives in 84% of cases, unschooled in 74.7% of cases. The maternal-fetal outcome was dominated by uterine rupture in 0.6% of cases, immediate postpartum hemorrhage in 9.8% of cases, vicious presentations in 5.5% of cases and cord prolapse in 6.8% of cases. CONCLUSION: Large multiparity is common in our practice. It is a high-risk pregnancy because of its many maternal-fetal complications.

BUT: Le but était de comparer le pronostic materno-fœtal des grossesses chez les grandes multipares à celui des autres parités. MATÉRIELS ET MÉTHODES: Nous avons réalisé une étude cas-témoins du 1er mars 2014 au 1er février 2015. Elle a concerné toutes les parturientes admises dans le service pendant la période d'étude. Nous avons choisi 1 cas pour 2 témoins. Ont été incluses comme cas toutes les grandes multipares et comme témoins les primipares, les paucipares et les multipares ayant accouchées juste avant et juste après le cas. Le test statistique utilisé a été le Chi2 avec un seuil de significativité fixé à 5%. RÉSULTATS: La fréquence de la grossesse chez la grande multipare était de 4,93%. Il s'agissait de femmes au foyer dans 84% des cas, non scolarisées dans 74,7% des cas. Le pronostic materno-fœtal a été dominé par la rupture utérine dans 0,6% des cas, l'hémorragie de la délivrance dans 9,8% des cas, les présentations vicieuses dans 5,5% des cas et la procidence du cordon dans 6,8% des cas. CONCLUSION: La grande multiparité est fréquente dans notre pratique. C'est une grossesse à haut risque à cause de ses nombreuses complications materno-fœtales.

[Pregnancy and delivery for women aged 40 years and over at the reference health center of commune II of Bamako district, Mali]. / Grossesses et accouchements chez les femmes de 40 ans et plus au centre de sante de reference de la commune II du district de Bamako, Mali.

GOAL: The aim of this study was to compare the maternal-fetal prognosis of pregnancies at 40 years of age and above with that of pregnancies obtained before 40 years of age in the obstetric gynecology department of the reference health center of commune II of Bamako district. MATERIALS AND METHODS: This was a prospective cohort study that was conducted at the maternity ward of Reference Health Center of Commune II of Bamako district from 1st January to 31 December 2012. Were included in our study as patients exposed, all the pregnant women of 40 years and over and as unexposed patients, pregnant women aged 20-39 who gave birth in our service. Teenage pregnancies were not included in this study. The statistical tests used were Pearson's Khi2 and Fisher's test with a significance level of 5%. RESULTS: The frequency of pregnancy among women aged 40 and over was 1.68%. These were large multiparas unschooled patients in 60% of cases, with hypertension in 6.7% of cases. Pregnancy in her patients was associated with a high rate of caesarean section in 16.7% of cases, term overrun in 6.7% of cases, seat presentation in 6.7% of cases, macrosomia in 6.7% of cases and fetal malformation in 1.7% of cases. CONCLUSION: Slight account of its many maternal-fetal complications, pregnancies in women 40 years and older deserve special attention.

BUT: Le but de cette étude était de comparer le pronostic materno-foetal des grossesses chez les patientes de 40 ans et plus à celui des grossesses conçues avant 40 ans dans le service de gynécologie obstétrique du centre de santé de référence de la commune II de Bamako. MATÉRIELS ET MÉTHODES: Il s'agissait d'une étude prospective de Cohorte qui s'est déroulée à la maternité du Centre de Santé de Référence de la Commune II du 1er janvier au 31décembre 2012. Ont été incluses dans notre étude comme patientes exposées toutes les gestantes de 40 ans et plus et comme patientes non exposées les gestantes de 20-39 ans ayant accouchées dans notre service. N'ont pas été retenues dans cette étude, les grossesses chez les adolescentes. Les tests statistiques utilisés ont été le Khi2 de Pearson et le test de Fisher avec un seuil de significativité à 5%. RÉSULTATS: La fréquence de la grossesse chez les femmes de 40 ans et plus était de 1,68%. Il s'agissait de grandes multipares non scolarisées dans 60% des cas, présentant une HTA dans 6,7% des cas. La grossesse chez ces patientes a été associée à un taux élevé de césarienne dans 16,7% des cas, de dépassement de terme dans 6,7% des cas, de présentation du siège dans 6,7% des cas, de macrosomie dans 6,7% des cas et de malformation foetale dans 1,7% des cas. CONCLUSION: Compte ténu de ses nombreuses complications materno-foetales, les grossesses chez les femmes de 40 ans et plus méritent une attention particulière.

[Neoadjuvant chemotherapy in locally advanced cervical cancer in patients receiving a concomitant chemoradiotherapy in a low income country]. / Chimiotherapie neo adjudante dans les cancers localement avances du col uterin chez des patientes recevant une radiochimiotherapie concomitante dans pays aux ressources limitees.

PURPOSE: Delays to access to radiotherapy are long in our context. The purpose of this study was to analyze the effect of neoadjuvant chemotherapy to concomitant chemoradiotherapy in locally advanced cervical cancers. PATIENTS AND METHODS: We conducted a retrospective study from April 2014 to April 2016 at the radiotherapy center of "Hopital du Mali" in Bamako, Mali. Patients were allocated according to age, histological type, tumor size and the 2002 classification of the FIGO. Experimental protocol was the administration of a neoadjuvante chemotherapy with association of Paclitaxel 175mg/m2 + Carboplatine AUC 5 every 3 weeks and radiothérapy cure with avec linac 6 MV at 70 Gy due to 5 sessions of 2 Gy per week associated with a concomitant chemotherapy with cisplatin at 40 mg/m2/week. The clinical response was assessed at the end of neoadjuvant chemotherapy and of concomitant chemoradiotherapy. RESULTS: Thirty patients were included in the study. The mean age was 53.63 ± 8.9 years. The mean size of the tumor was 5.17 cm (2 to 7 cm). According to the 2002 classification of the FIGO stages IIB were 33% (n = 10); IIIB were 57% (n = 17) and IVA were 10% (n = 3). Clinical evaluation at the end of neoadjuvant chemotherapy found: complete response 17 % (n = 5), partial response 10% (n = 3) and stable disease 73 % (n = 22). Evaluation at the end of the concomitant chemoradiotherapy had found the complete response in 90% (n = 27) and stable disease in 10% (n = 3). CONCLUSION: Neoadjuvant chemotherapy to concomitant chemoradiotherapy in locally advanced cervical cancer allows stabilization of the tumor and improves local control. Due to long delays to access to radiotherapy treatment in our context; neoadjuvant chemotherapy is an alternative to stabilize the disease and prevent distant metastasis from locally advanced cervical cancers.

OBJECTIF: Les délais d'attente pour accéder à la radiothérapie sont longs dans note contexte. L'objet de cette étude était d'analyser le résultat de la chimiothérapie néo adjuvante à la radiothérapie dans les cancers localement avancés du col utérin. PATIENTS ET MÉTHODES: Nous avons réalisé une étude rétrospective allant d'avril 2014 à avril 2016 au centre de radiothérapie de l'hôpital du Mali. Les patients ont été regroupés selon l'âge, le type histologique, la taille de la tumeur, la classification de la FIGO 2002. Le schéma thérapeutique était une chimiothérapie néo adjuvante associant Paclitaxel 175 mg/m2 et Carboplatine AUC 5 toutes les 3 semaines suivie d'une radiothérapie avec linac 6 MV à la dose de 70 Gy en raison de 5 séances de 2 Gy par semaine faite concomitamment à une chimiothérapie avec du cisplatine à la dose de 40 mg/m2/semaine. La réponse clinique était évaluée à la fin de la chimiothérapie néoadjuvante et de la radiochimiothérapie concomitante. RÉSULTATS: Trente patientes ont été incluses dans l'étude. L'âge moyen était de 53.63 ± 8.9 ans. La taille moyenne de la tumeur était de 5,17 cm (2 à 7 cm). Selon la classification FIGO 2002, 10 (33%) étaient en stade IIB distal, 17 (57%) étaient en stade IIIB et 3 (10%) en stade IVA. L'évaluation clinique à la fin de la chimiothérapie néo adjuvante avait retrouvé 17 % de réponses complètes (n=5), 10% de réponses partielles (n=3) 73 % d'évolutions stables (n=22). L'évaluation à la fin de la radiochimiothérapie concomitante avait trouvé une réponse complète chez 27 patientes (90%) et une maladie stable chez 3 (10%). CONCLUSION: La chimiothérapie néo adjuvante à la chimioradiothérapie concomitante dans les cancers localement avancés du col utérin permet la stabilisation de la tumeur et améliore le control local. En raison des délais d'attente longs pour accéder à la radiothérapie, la chimiothérapie néo adjuvante est une alternative pour stabiliser la maladie et réduire le risque de métastases à distance des cancers du col utérin localement avancés.

[Assessment of the use of partogram at the district maternity hospital of commune II in Bamako area]. / Evaluation de L'Utilisation du Partogramme a la Maternite du Centre de Sante de Reference de la Commune V du Distict de Bamako.

OBJECTIVE: To estimate the use of the partogram at the district hospital of commune II in Bamako area; to identify the risk factors by pregnant women and her newborn babies ; to appreciate the filling quality of the partogram; to determine the sensibility, the specificity and the predictive worth of the alert line. METHOD: Our study has been conducted at the district hospital of commune II in Bamako area because of his high examination rate. The study was retrospective, analytic and transversal, conducted during 12 months (from first January 2005 to 31 st December 2005). Were considered in this study, partograms of all pregnant women, who have been admitted to delivery in the hospital during the study period and whom labor was monitored with partogram from latence phase or active phase. Were excluded, partograms of women, who has delivered at home, the one who have suffered prophylactic cesarean and the one who have been admitted with a cervix dilatation ≥8 cm. RESULTS: 287 partograms ( 18,85%) were correctly filled; 64% of the deliveries were performed left of the alert line; 31,3% right of the alert line; 4,7% right of the action line. 83,04% of the pregnant women performed at least one prenatal examination, the age bracket of 15 to 19 years shows a little predominance with 27% of cases; 46,71% among them have delivered right of the alert line. The primigravidas represent 32% of the sample; among them, 38% got over the alert line and 7,93% the action line. Women smaller than 150 cm represent 1,05% ( 16 cases). In this bracket 68,75% ( 11 cases) suffered caesarean, 31,25% (5 cases) delivered normal. The caesarean has been performed again by 61,45% of the pregnant women, who had a previous cesarean, 29,52% have delivered normal. Concerning the newborn babies, 1,24% coming from the 84,95% deliveries whom labor time was lower than 10 hours, 51,98% those coming from the 13,27% deliveries whom labor time was between 11 and 24 hours, 100% of those coming from the 1,77% deliveries whom labor time was over 24 hours, had a low Apgar score at birth. 65,06% of the newborn babies delivered from the 5,45% women with greenish amniotic liquid have a low Apgar score against 3,32% of those from 73,32% with clear amniotic liquid.

[Assessment of the use of partogram at the district maternity hospital of commune II in Bamako area]. / Evaluation de L'utilisation du Partogramme a la Maternite du Centre de Sante de Reference de la Commune V du Distict de Bamako.

OBJECTIVE: To estimate the use of the partogram at the district hospital of commune II in Bamako area; to identify the risk factors by pregnant women and her newborn babies; to appreciate the filling quality of the partogram; to determine the sensibility, the specificity and the predictive worth of the alert line. METHODOLOGY: Our study has been conducted at the district hospital of commune II in Bamako area because of his high examination rate. The study was retrospective, analytic and transversal, conducted during 12 months (from first January 2005 to 31 st December 2005). Were considered in this study, partograms of all pregnant women, who have been admitted to delivery in the hospital during the study period and whom labor was monitored with partogram from latence phase or active phase. Were excluded, partograms of women, who has delivered at home, the one who have suffered prophylactic cesarean and the one who have been admitted with a cervix dilatation ≥ 8 cm. RESULTS: 287 partograms (18.85%) were correctly filled; 64% of the deliveries were performed left of the alert line; 31.3%right of the alert line; 4.7% right of the action line. 83.04% of the pregnant women performed at least one prenatal examination, the age bracket of 15 to 19 years shows a little predominance with 27% of cases; 46.71% among them have delivered right of the alert line. The primigravidas represent 32% of the sample; among them, 38% got over the alert line and 7.93% the action line. Women smaller than 150 cm represent 1.05% ( 16 cases). In this bracket 68.75% (11 cases) suffered caesarean, 31.25% (5 cases) delivered normal. The caesarean has been performed again by 61.45% of the pregnant women,who had a previous cesarean, 29.52% have delivered normal. Concerning the newborn babies, 1.24% coming from the 84.95% deliveries whom labor time was lower than 10 hours, 51.98% those coming from the 13.27% deliveries whom labor time was between 11 and 24 hours, 100% of those coming from the 1.77% deliveries whom labor time was over 24 hours, had a low Apgar score at birth. 65.06% of the newborn babies delivered from the 5.45% women with greenish amniotic liquid have a low Apgar score again 3.32% of those from 73.32% with clear amniotic liquid.

[Neurologic disorders in pregnancy and post-partum period at the neurology service of Chu du Point-G and the referral center of the Commune V of Bamako]. / Troubles neurologiques au cours de la grossesse et du post-partum dans le service de neurologie du Chu du Point-G et du Centre de Reference de la Commune V de Bamako.

The objective of the study was to describe epidemiological and clinical characteristic of acute vascular accidents, epilepsies and eclampsy, observed during the periods of pregnancy and post delivery. The study was prospective, conducted during 19 mouths from August 2005 to February 2007. Women aged from 15 to 45 years were considered, presenting neurological disorders. Among 6914 consulted patients, 37 were recruited and presenting required criteria of neurological disorders (3.02%). Most of the case (48.7%) were between the ages of 15 to 25 years. Epilepsy was detected in 51.40% of this group, acute vascular accidents 37.83% and eclampsy 13.51% of the cases. The evolution of the pregnancy was favorable eutopic delivery was frequent, only 1 caesarean has been registered.

[Dysmenorrhea in adolescents: epidemio-clinical study at the referral health center, Bamako District. Report of 300 cases]. / La dysmenorhee chez l'adolescente : etude epidemio-clinique au centre de santede reference de la commune II du District de Bamako a propos de 300 cas.

This clinical epidemiological study has been conducted at the district hospital of Commune II in Bamako area.Dysmenorrhea has become a very common feature during out patients consultation. It affects almost one adolescent out of 3 examined during this study which represent 42, 8% of the studied population ranged from 10 to 19 years, with a men age of 16 years. Most of them were household women (50%),never pregnant (60%) and never delivery (64%). Most of them have been mainly claiming about contraction pain (33%) and discomfort (17,3%). The pain has been followed by asthenia (86,7%), and irritability (87,7%).Dysmenorrhea was a major cause of absenteism (48,3%). The factors influencing this type of dysmenorhea was the age and psychological stress.

[Induced abortion. Report of 180 cases at the Gabriel Toure Hospital]. / L'avortement provoque a propos de 180 cas a l'Hôpital Gabriel Toure.

A prospective case study on provocated abortion has been conducted at gynaecology and obstetric department of Hôpital Gabriel Touré from September 2003 to June 2004. We included in the study 180 cases and 360 controls (normal delivery pregnant women) matched by age to the cases. 5 04% of our cases undergone a provocated abortion; in 47.8%, the abortion was provoked by paramedical personal. Hemorrhagic complication was noted in 71.1%. The main reason of provocated abortion was single women, family pressure, fair of society and uncontrolled contraception.

[Socio-demographic and prognostic aspects of unfollowed pregnancies of patients admitted in the Department of Gynaecology-Obstetric of Gabriel Toure Hospital]. / Aspects socio-demographiques et pronostic des grossesses non suivies chez les patientes admises dans le Service de Gynecologie-Obstetrique de l'Hopital Gabriel Toure.

UNLABELLED: The prenatal followed up permit, on the one hand, to track down risk pregnancies, to appreciate the evolution of pregnancy and its repercussion on the maternal state, to finally make the prognosis of the childbirth and on the other hand to identify risk pregnancies and to assure a management outside emergency context. They contribute this fact to the meaningful reduction of the maternal mortality. The non followed up pregnancies are characterized by their important maternal and fetal mortality and morbidity. The aim of our survey was to determine the frequency of the unfollowed pregnancies, to describe the socio demographic profile of the women and to determine the prognosis of these pregnancies. MATERIAL AND METHODS: Our survey had for setting the service of Gynecology and obstetrics of Gabriel Touré hospital. Center of cares, research and formation, this service that is 3rd level in the sanitary pyramid in Mali, receives emergencies from other motherhoods of lower level. Were include in this survey, women who delivered in the service and hadn't done any prenatal consultation. Criterias of non inclusion were next one: women having done at least a prenatal consultation, women having delivered in another sanitary structure, all cases of non assisted childbirths, women whose gestational age is lower to 28 weeks and/or fetal weight lower than 500 grams. Every case has been matched to a witness (consistent woman who has been followed and delivered in the service) according to criterias of age and parity. The statistical tests used to study associations between variables are the chi2 with a significativity doorstep of P = 0.05 and Odd ratio (OR). RESULTS: We recorded 2173 childbirths and 286 non followed pregnancies been 13.16% of frequency. The middle age of our patient was 23 years with extremes of 16 and 44 years, nullipareses represented 25.9% of cases. The domestic helps were more numerous in the group of cases with 4.9% against 0.3% in the witness group (P = 0.0006, OR = 14.6; IC [2.01, 30.05]). The maternal prognosis is marked by 2.1% of death (P = 0.013). Fetal prognosis is bad with 10.9% of child stillborn (P = 0.0007; OR = 3.19) and 21.5% of morbid APGAR. CONCLUSION: The absence of prenatal consultation is associated to a height maternal and fetal mortality and morbidity.

[Association of extrauterine and intrauterine pregnancy: 3 cases]. / Association grossesse extra uterine et intra uterine: a propos de 3 cas.

Extra uterine pregnancy (GEU) constitutes, by its frequency a problem of public health, by its gravity an obstetric emergency and a problem of fertility for the woman. It represents the chief reason of maternal death during the first quarter of pregnancy. The association of extra-uterine and intra-uterine pregnancy is a particular case of twin pregnancy said ditopic. It is rare, but non exceptional. The authors bring three cases to remind us of its existence.

VAGINAL HYSTERECTOMY IN THE DEPARTMENT OF OBSTETRICS AND GYNECOLOGY OF THE Point "G" HOSPITAL.

Our survey consisted in evaluating the prevalence, specifying the indications and describing per and post - operation complications of vaginal hysterectomy in the Department of Gynecology and Obstetrics of the National Hospital of "Point G ". We conducted a descriptive retrospective survey on 58 cases of vaginal hysterectomies performed in that Department from 1995 to December 2000. Vaginal hysterectomies represented 27.3% of all hysterectomies done in the Department. The mean age of the patient was of 56 +/-2 years. The mean parity was 8. In 91.4% of cases this intervention was a step of the cure of a 3rd degree genital prolapsus. Ménométrorragia represented 5.2%, myomatus delivered by the cervix represented 1.7% and high rank cervical dysplasis was 1.7%. Per and post - surgery complications were dominated by perineal infections (5.2%), hemorrhage (1.7%) and urine retention (1.7%). The mean length of hospitalization was of 7+/-2 days. Vaginal hysterectomy is praticable in our context and secondary morbidity remains within acceptable limits. Because of its advantages this technique must be popularized.

Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls.

Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months to 14 years residing in Bandiagara, Mali, were matched to cases of uncomplicated malaria and healthy controls. Using modified World Health Organization criteria for defining severe malaria, we identified 100 cases of cerebral malaria (coma, seizure, and obtundation), 17 cases of severe anemia (hemoglobin, <5 g/dl), 18 cases combined cerebral malaria with severe anemia, and 92 cases with hyperparasitemia (asexual trophozoites, >500,000/mm3). Significantly elevated levels (given as geometric mean concentrations in picograms/milliliter) of interleukin-6 (IL-6; 485.2 versus 54.1; P = <0.001), IL-10 (1,099.3 versus 14.1; P = <0.001), tumor necrosis factor alpha (10.1 versus 7.7; P = <0.001), and IL-12(p70) (48.9 versus 31.3; P = 0.004) in serum were found in severe cases versus healthy controls. Significantly elevated levels of IL-6 (485.2 versus 141.0; P = <0.001) and IL-10 (1,099.3 versus 133.9; P = <0.001) were seen in severe malaria cases versus uncomplicated malaria controls. Cerebral malaria was associated with significantly elevated levels of IL-6 (754.5 versus 311.4; P = <0.001) and IL-10 (1,405.6 versus 868.6; P = 0.006) compared to severe malaria cases without cerebral manifestations. Conversely, lower levels of IL-6 (199.2 versus 487.6; P = 0.03) and IL-10 (391.1 versus 1,160.9; P = 0.002) were noted in children with severe anemia compared to severe malaria cases with hemoglobin at >5 g/dl. Hyperparasitemia was associated with significantly lower levels of IL-6 (336.6 versus 602.1; P = 0.002). These results illustrate the complex relationships between inflammatory cytokines and disease in P. falciparum malaria.

[Complications of illegal induced abortions at Bamako (Mali) between December 1997 and November 1998]. / Complications des avortements provoqués illgaux à Bamako (Mali) de décembre 1997 à novembre 1998.

We carried out a descriptive retrospective study over a period of one year, in the Gynecology and Obstetrics Referrals Department of Gabriel-Touré Hospital at Bamako. We analyzed 1,081 files of patients presenting at the department with complications of spontaneous or induced abortion. We identified and studied 189 cases of illegal induced abortions. The patients were young (mean age 21.8 years), of a low socioeconomic level and most (71.4%) had no living child. The gestational age of the fetus was less than 12 weeks for 19.5% of the women and between 13 and 16 weeks for 47.6%. The abortions were carried out by traditional practitioners (3.7%), general practitioners (9%), trainee nurses (10.5%) and state nurses and midwives (57.1%). In more than half the cases (71.4%), the abortion took place at the home of the practitioner. Several methods of abortion were used (e.g. curettage, uterine probes). In 44.4% of the cases, the woman refused to comment on the reasons for the abortion. The other women cited mostly academic reasons (20.63% of cases) and fear of their parents (13.22%). The main reasons for consultation were bleeding (51.3%), hyperthermia (35.4%), pain (9. 52%) and neurological problems (3.1%). Three types of complication were identified: bleeding (47%), infectious complication (33.3%) and drug poisoning (4.2%). The rate of maternal mortality was 10% and the management of the patients required surgical (from curettage to hysterectomy) and medical treatment, with a mean stay in hospital of 10 days.