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1.
Tijdschr Psychiatr ; 66(6): 301-307, 2024.
Artigo em Holandês | MEDLINE | ID: mdl-39162153

RESUMO

BACKGROUND: Few studies have been conducted on personality traits and psychopathology in females and males with borderline intellectual functioning. AIM: Examining gender differences in psychopathology and behavioral characteristics in patients with borderline intellectual functioning, and patients with average intellectual functioning. METHOD: The MMPI-2-RF was administered to 116 patients with borderline intellectual functioning and psychopathology. Average raw scores on the Restructured Clinical Scales (RC-scales) of female and male patients with borderline intellectual functioning were compared to those of a matched group from the general population, and a matched group with patients with mental disorders and average intelligence. The average raw scores on the RC-scales were compared between males and females with borderline intellectual functioning and between females and males across the various groups. RESULTS: Female patients with borderline intellectual functioning reported more symptoms on RC-scales related to internalizing emotional problems than male patients with borderline intellectual functioning. They reported significantly more complaints on RC-scales related to externalizing problems and thought disorders compared to average intelligent females with mental disorders. Several significant differences between female and male patients with borderline intellectual functioning were greater than within the other groups. We found no significant differences in behavioral characteristics and symptoms between male patients with borderline intellectual functioning and average intelligent males with mental disorders. CONCLUSION: This study underscores the importance of gender sensitivity in the multi-method assessment and treatment of psychopathology in patients with borderline intellectual functioning. Female patients with borderline intellectual functioning constitute the most vulnerable group in terms of nature and severity of psychopathology.


Assuntos
Inteligência , Personalidade , Humanos , Masculino , Feminino , Adulto , Fatores Sexuais , Transtorno da Personalidade Borderline/psicologia , Adulto Jovem
2.
Artigo em Inglês | MEDLINE | ID: mdl-39129191

RESUMO

BACKGROUND: Stressful life events are events that do not fulfil the A criterion of PTSD in the DSM-5(TR) but are perceived as negative by the person. There is an ongoing debate about the usefulness of the A criterion as a gate criterion for PTSD, and especially regarding which events qualify as traumatic or stressful life events. This debate is particularly important for individuals with intellectual disabilities (ID) or borderline intellectual functioning (BIF), as they seem to be more likely to experience traumatic and stressful life events than their peers without ID-BIF and appear to be more susceptible to the disruptive effects of these events. As a result, people with ID-BIF are more likely to develop mental health and behavioural problems. There is insufficient knowledge about how the relationship between stressful life events and PTSD symptoms should be interpreted, how traumatic and stressful life events are defined and distinguished in people with ID, and whether the A criterion should be broadened for individuals with ID-BIF. The aim of this scoping review was to understand stressful life events and their relationship with PTSD symptoms, other mental health and/or behavioural problems in individuals with ID-BIF. METHODS: The scoping review was conducted in accordance with the JBI methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). RESULTS: Thirty-eight studies were included. Five studies focused on stressful life events and PTSD symptoms. The other studies examined associations between stressful life events and other mental health and/or behavioural problems. Most of the studies did not clearly differentiate between stressful and traumatic events according to the A criterion of PTSD in the DSM-IV (TR) or DSM-5(TR). Of the six studies in which stressful life events were specified and could be distinguished from traumatic events, one found a positive association between PTSD symptoms and stressful life events and five showed weak to strong positive associations with other mental health and/or behavioural problems. CONCLUSIONS: PTSD symptoms following stressful life events in individuals with ID-BIF are underrepresented in the literature. The lack of a clear definition of stressful life events leads to a gap in the knowledge on whether and how stressful life events may lead to PTSD symptoms, other mental health and/or behavioural problems in individuals with ID-BIF. Therefore, no general conclusions or recommendations can be made regarding the appropriateness of the PTSD A criterion for individuals with ID-BIF. Further research is needed to establish the role of stressful life events in relation to PTSD symptoms and to inform the assessment and effective treatment in people with ID-BIF, as expert clinical experience studies suggest that broadening the PTSD A criterion should be considered for people with ID-BIF.

3.
J Appl Res Intellect Disabil ; 37(3): e13212, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38382539

RESUMO

INTRODUCTION: This study investigated the reliability and validity of the dynamic risk outcome scales-short version (DROS-SV). This instrument is developed to monitor treatment progress using dynamic risk factors in clients with mild intellectual disabilities or borderline intellectual functioning and behavioural and/or mental health problems. METHOD: Data were collected from 264 clients who received Flexible Assertive Community Treatment (FACT), a form of intensive outpatient treatment. RESULTS: A principal component analysis showed that there were six components explaining 73.9% of the variance. Furthermore, the DROS-SV showed good internal consistency of its subscales and total score (α > 0.78). Correlating the DROS-SV with the Historical and Clinical subscales of the Historical, Clinical and Future-30 indicated convergent and divergent validity. DISCUSSION: The DROS-SV has good psychometric properties for measuring dynamic risk factors in clients with mild intellectual disabilities or borderline intellectual functioning in FACT teams.


Assuntos
Serviços Comunitários de Saúde Mental , Deficiência Intelectual , Humanos , Deficiência Intelectual/psicologia , Reprodutibilidade dos Testes , Psicometria
4.
J Appl Res Intellect Disabil ; 37(1): e13183, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38043530

RESUMO

BACKGROUND: In secure residential facilities, group climate perceptions of clients with mild intellectual disability or borderline intellectual functioning are systematically assessed for quality improvement. A valid and reliable measure may ensure that this process is consistent. The Group Climate Inventory-Revised (GCI-R) is a new measure to assess group climate perceptions. METHOD: Confirmatory factor analysis was conducted in 148 adult clients (79% male) with mild intellectual disability or borderline intellectual functioning in a secure facility to examine internal structure validity and internal consistency reliability of the GCI-R. RESULTS: The results indicate support for the five-factor structure of the GCI-R ('Support', 'Growth', 'Repression', 'Peer interactions', and 'Physical environment'). The internal consistency reliability of its scales ranged from acceptable to good (α: .72-.87; ω: .76-.86). CONCLUSION: The GCI-R demonstrates evidence of psychometric adequacy when applied to adult clients with mild intellectual disability or borderline intellectual functioning in secure residential facilities.


Assuntos
Deficiência Intelectual , Deficiências da Aprendizagem , Adulto , Humanos , Masculino , Feminino , Psicometria , Reprodutibilidade dos Testes , Instituições Residenciais , Processos Grupais
5.
J Intellect Disabil Res ; 67(8): 782-795, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37249055

RESUMO

BACKGROUND: This study explored the perceptions of staff for people with mild intellectual disabilities or borderline intellectual functioning and severe challenging behaviour in relation to the support they received at work from four groups of professionals (i.e. team leaders, managers, psychologists and other staff members). The team climate, such as the workplace having clearly defined goals for staff, was also explored. In addition, the associations between the support from each of the professionals and team climate with the well-being and job satisfaction of staff were examined. We hypothesised that staff would perceive higher levels of support from professionals around a team (i.e. team leaders, managers and psychologists) and a more positive team climate when professionals around a team experience more positive mutual collaboration. METHODS: An online questionnaire about support at work, team climate, well-being and job satisfaction was completed by 201 staff members from 32 teams at 10 residential service organisations. In addition, professionals surrounding these teams rated their mutual collaboration. RESULTS: Both support received at work from all four groups of professionals and team climate showed significant small to moderate positive associations with job satisfaction. Well-being was associated with support from team leaders, psychologists and other staff members in the team, as well as with team climate. We did not find support for the hypotheses that staff would perceive higher levels of support or a more positive team climate when professionals around a team experience more positive mutual collaboration. CONCLUSIONS: This study highlights the importance of investing in staff support and creating a positive team climate for promoting staff well-being and job satisfaction. Implications for future research regarding staff support, team climate and the collaboration between professionals around a team are discussed.


Assuntos
Deficiência Intelectual , Humanos , Estudos Transversais , Inquéritos e Questionários , Satisfação no Emprego , Equipe de Assistência ao Paciente
6.
J Appl Res Intellect Disabil ; 36(3): 641-652, 2023 May.
Artigo em Inglês | MEDLINE | ID: mdl-36883307

RESUMO

BACKGROUND: Relationships between dynamic risk factors for externalising problem behaviour and group climate were investigated in 151 adult in-patients with mild intellectual disability or borderline intellectual functioning in a Dutch secure residential facility. METHOD: Regression analysis was used to predict total group climate score and Support, Growth, Repression, and Atmosphere subscales of the 'Group Climate Inventory'. Predictor variables were Coping Skills, Attitude towards current treatment, Hostility, and Criminogenic attitudes subscales of the 'Dynamic Risk Outcome Scales'. RESULTS: Less hostility predicted a better overall group climate, better support and atmosphere, and less repression. A positive attitude towards current treatment predicted better growth. CONCLUSION: Results indicate relationships of hostility and attitude towards current treatment with group climate. A focus on both dynamic risk factors and group climate may provide a basis for improving treatment for this target group.


Assuntos
Deficiência Intelectual , Comportamento Problema , Humanos , Adulto , Deficiência Intelectual/terapia , Fatores de Risco , Etnicidade , Processos Grupais
7.
J Appl Res Intellect Disabil ; 36(4): 750-757, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36883334

RESUMO

BACKGROUND: The dynamic risk outcome scales (DROS) was developed to assess treatment progress of clients with mild intellectual disability or borderline intellectual functioning using dynamic risk factors. We studied the predictive value of the DROS on various classifications and severity levels of recidivism. METHOD: Data of 250 forensic clients with intellectual disabilities were linked to recidivism data from the Judicial Information Service in the Netherlands. Receiver operating characteristics (ROC) analyses were used to determine the predictive values. RESULTS: The DROS total score could not significantly predict recidivism. A DROS recidivism subscale predicted general, violent and other recidivism. These predictive values were comparable to those of a Dutch tool validated for risk assessment in the general forensic population. CONCLUSIONS: The DROS recidivism subscale predicted various classifications of recidivism better than chance. At present, the DROS appears to have no added value beyond the HKT-30 for the purpose of risk assessment.


Assuntos
Deficiência Intelectual , Deficiências da Aprendizagem , Reincidência , Humanos , Deficiência Intelectual/epidemiologia , Medição de Risco , Fatores de Risco , Psiquiatria Legal
8.
Tijdschr Psychiatr ; 64(10): 650-656, 2022.
Artigo em Holandês | MEDLINE | ID: mdl-36583274

RESUMO

BACKGROUND: There are few psychometrically sound diagnostic instruments available to assess personality characteristics and psychopathology in patients with borderline intellectual functioning (BIF). It is important to assess personality characteristics and psychopathology in this target group because of their high risk on psychopathology. AIM: To determine whether the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) is feasible in patients with BIF (Verbal Comprehension Index = 70-85) and psychopathology. METHOD: We examined scores on validity scales of the MMPI-2-RF of patients with BIF and compared these scores to those of a matched group of individuals with average intellectual functioning without psychopathology. RESULTS: Scores on the validity scales indicated that patients with BIF can report in a consistent and valid way about their complaints and personality characteristics. Compared to the comparison group they reported equally consistent and showed significantly more psychopathology. CONCLUSION: The MMPI-2-RF is feasible in the assessment of personality characteristics and psychopathology in patients with BIF..


Assuntos
Deficiência Intelectual , MMPI , Humanos , Estudos de Viabilidade , Psicopatologia , Reprodutibilidade dos Testes
9.
Tijdschr Psychiatr ; 62(12): 1022-1029, 2020.
Artigo em Holandês | MEDLINE | ID: mdl-33443755

RESUMO

BACKGROUND: Little is known about suicide among individuals with mild intellectual disabilities (mid).
AIM: To explore risk factors for suicide among a small group of clients with mid who committed suicide.
METHOD: Case files of 11 clients with mid were analysed using the Integrated Motivational Volitional model.
RESULTS: Most suicides seem to have taken place impulsively and not on the basis of a predetermined plan. Most clients had comorbid mental health problems, predominantly trauma-related, impulse control and externalizing behavioural problems. The (imminent) loss of contact, such as in the case of transfer from one ward to another ward or to a facility, seems an important risk factor for suicide.
CONCLUSION: Clients with mid residing in a treatment facility may have an increased risk of suicide because of an interaction between client characteristics and treatment context.


Assuntos
Deficiência Intelectual , Suicídio , Humanos , Deficiência Intelectual/epidemiologia , Fatores de Risco
10.
Tijdschr Psychiatr ; 62(12): 1040-1048, 2020.
Artigo em Holandês | MEDLINE | ID: mdl-33443757

RESUMO

BACKGROUND: The Dynamic Risk Outcome Scales (DROS) was developed to assess treatment progress of patients with mild intellectual disability (MID) or borderline intellectual functioning (BIF) and severe behavioral and/or psychiatric problems. Because of the focus on dynamic risk factors, practitioners also see this instrument as a tool for risk assessment.
AIM: To investigate the predictive value of the DROS on different classifications and severities of recidivism.
METHOD: DROS data from the routine outcome monitoring (ROM) of 250 forensic patients with MID-BIF who were discharged between 2007 and end of 2014 were linked to recidivism data from the Judicial Information Service.
RESULTS: The DROS total score predicted general, violence and sexual recidivism better than chance (AUCs > 0.58), although the effect was small. A DROS-recidivism subscale predicted general, violence and other recidivism with a medium to large effect (AUCs > 0.67). The predictive values of the DROS total score and DROS-recidivism subscale were comparable to those of the Historic, Clinical, Future (in Dutch: HKT)-30.
CONCLUSION: The DROS total score and DROS-recidivism subscale predict different classifications of recidivism better than chance. However, for risk assessment the DROS appears to have no added value to the HKT-30.


Assuntos
Deficiência Intelectual , Reincidência , Psiquiatria Legal , Humanos , Deficiência Intelectual/diagnóstico , Medição de Risco , Violência
11.
J Intellect Disabil Res ; 63(8): 1015-1022, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30991450

RESUMO

BACKGROUND: Assertive community treatment (ACT) and Flexible assertive community treatment (FACT) are organisation models for intensive assertive outreach that were originally developed for individuals with severe mental illness. The models are increasingly applied to people with mild intellectual disability (MID) or borderline intellectual functioning (BIF) and challenging behaviour or mental illness. Research on these types of care for this population is limited. To gain experience in FACT MID/BIF in the Netherlands and to obtain insight in its outcomes, four organisations specialised in the treatment of individuals with MID/BIF and challenging behaviour participated in a 6-year implementation and research project. METHODS: A longitudinal study was set up to investigate outcomes over time. Outcome measures concerned admissions to (mental) health care, social and psychological functioning, (risk of) challenging and criminal behaviour, social participation and client satisfaction. Data were analysed using descriptive statistics and linear mixed models. RESULTS: Over time, clients showed improvement in their social and psychiatric functioning and living circumstances. The number of admissions to (mental) health care diminished as well as the number of contacts with police and justice, the level of social disturbance and the risk factors for challenging and criminal behaviour. Problems related to finances, work and substance abuse remained unchanged. CONCLUSIONS: The results are encouraging and give rise to continued development of and broader research on FACT MID/BIF.


Assuntos
Serviços Comunitários de Saúde Mental/métodos , Deficiência Intelectual/reabilitação , Avaliação de Processos e Resultados em Cuidados de Saúde , Adolescente , Adulto , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Países Baixos , Índice de Gravidade de Doença , Adulto Jovem
12.
J Intellect Disabil Res ; 63(3): 215-224, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30456768

RESUMO

BACKGROUND: This study examined the psychometric properties of the Group Climate Instrument (GCI) in a sample of N = 189 adults (79% men) with mild intellectual disability or borderline intellectual functioning who were residents of a treatment facility in the Netherlands. METHOD: Construct validity of the GCI was examined by means of confirmatory factor analysis. Also, reliability and convergent validity of the GCI were examined. We also examined the variability in perception of the living group climate between and within living groups by computing intraclass correlation coefficients. RESULTS: The model contained four first-order factors (support, growth, group atmosphere and repression) and a second-order factor overall climate, providing preliminary support for construct validity of the GCI. Reliability coefficients were good for all factors. Preliminary evidence for convergent validity was found in significant moderate associations between subscales and single item ratings for the factors of group climate. The intraclass correlation coefficients indicated that a considerate proportion of variance can be attributed to between-group differences. CONCLUSIONS: The GCI might be used to assess perception of the living group climate for individuals with mild intellectual disability or borderline intellectual functioning in psychiatric and forensic care settings, although further development of the GCI and replication of our findings seem necessary.


Assuntos
Processos Grupais , Deficiência Intelectual/psicologia , Deficiência Intelectual/terapia , Psicometria/normas , Tratamento Domiciliar , Adulto , Feminino , Humanos , Masculino , Modelos Psicológicos , Países Baixos , Psicometria/instrumentação , Reprodutibilidade dos Testes
13.
J Intellect Disabil Res ; 61(3): 255-265, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-27585827

RESUMO

BACKGROUND: Problematic drinkers favour the processing of alcohol-related stimuli at the cost of other stimuli and also find it difficult to disengage their attention from these stimuli. This is indicative of an attentional bias towards alcohol. The goal of this study was to examine this bias in problematic drinkers with and without mild to borderline intellectual disability (MBID) using both eye tracking methodology and behavioural data (i.e. reaction time (RT) data). METHOD: Participants (N = 133) were divided into four groups based on (estimated) full scale intelligence quotient (IQ) and severity of alcohol use-related problems. The severity of substance use-related problems was assessed with the Alcohol Use Disorder Identification Test (AUDIT). The visual dot probe task was used to measure the attentional bias. We analysed both eye tracking data and behavioural data (i.e. RT data) of the visual dot probe task. RESULTS: Problematic drinkers were not more likely than light drinkers to direct their attention towards pictures of alcoholic beverages, did not look at these pictures longer than light drinkers and did also not respond faster than light drinkers to probes replacing pictures of alcoholic beverages. However, the strength of the attentional bias varied profusely. CONCLUSION: Taking the large variability in the strength of the attentional bias and the poor psychometric qualities of the measures into consideration, it is concluded that the use of these measures for clinical purposes is discouraged.


Assuntos
Transtornos Relacionados ao Uso de Álcool/fisiopatologia , Viés de Atenção/fisiologia , Deficiência Intelectual/fisiopatologia , Adolescente , Adulto , Idoso , Medições dos Movimentos Oculares/normas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos/normas , Índice de Gravidade de Doença , Adulto Jovem
14.
J Intellect Disabil Res ; 60(3): 242-53, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26667160

RESUMO

BACKGROUND: Substance use disorders (SUD) are associated with several neurobiological disruptions, including biases in attention and approach/avoidance behaviour. The aims of this study were to compare the strength of cognitive biases between light and problematic drinkers, to explore the role of IQ on the cognitive biases and to study the psychometric qualities of the measures. METHOD: Participants (N = 130) were divided into four groups based on IQ and severity of alcohol use-related problems: light (n = 28) and problematic drinkers (n = 25) with (sub)average IQ and light (n = 33) and problematic drinkers (n = 44) with mild to borderline intellectual disability (MBID). All participants performed the visual dot probe task and the approach avoidance task to measure the strength of cognitive biases. RESULTS: In contrast with the hypothesis, no cognitive biases were found in problematic drinkers. Full scale IQ nor level of craving influenced the strength of the cognitive biases in light and problematic drinkers, although IQ did influence task performance (i.e. large intra-individual, trial-to-trial variation in reaction time). The internal consistency of the visual dot probe task was good, whereas the internal consistency of the approach avoidance task was poor. CONCLUSION: Cognitive biases seem to vary within the group of problematic drinkers as a whole. The psychometric qualities of the measures are problematic, especially in relation to the intra-individual variability in reaction time found in participants with MBID. Until the implications of this variability on the validity of implicit measures and establishing bias scores are more clear, the use of these measures in individuals with MBID calls for scrutiny.


Assuntos
Consumo de Bebidas Alcoólicas/psicologia , Transtornos Relacionados ao Uso de Álcool/psicologia , Atitude , Deficiência Intelectual/psicologia , Adulto , Feminino , Humanos , Masculino , Índice de Gravidade de Doença
15.
J Autism Dev Disord ; 45(2): 495-505, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24062183

RESUMO

Several studies indicate that autonomic and endocrine activity may be related to social functioning in individuals with autism spectrum disorder (ASD), although the number of studies in adults is limited. The present study explored the relationship of autonomic and endocrine activity with social functioning in young adult males with ASD compared to young adult males without ASD. Autonomic and endocrine activity (i.e. heart rate, heart rate variability and salivary cortisol) were measured during rest and social interaction. No differences in heart rate, heart rate variability and cortisol between both groups were found during rest and social interaction. Repeated measures ANOVA's indicate a main effect of time for heart rate and cortisol, indicating an increase in these measures for both groups. An interaction effect between time and group was found for heart rate, with the ASD group showing a blunted increase in heart rate from rest to social interaction as compared to those without ASD. Future research should focus on replicating the present findings with larger sample sizes which also enables assessing inter-individual variability in autonomic and endocrine activity in relation to social functioning.


Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Transtornos Globais do Desenvolvimento Infantil , Hidrocortisona/metabolismo , Relações Interpessoais , Adolescente , Adulto , Estudos de Casos e Controles , Transtornos Globais do Desenvolvimento Infantil/metabolismo , Transtornos Globais do Desenvolvimento Infantil/fisiopatologia , Transtornos Globais do Desenvolvimento Infantil/psicologia , Frequência Cardíaca/fisiologia , Humanos , Masculino , Saliva/metabolismo , Adulto Jovem
16.
Dev Neurorehabil ; 17(1): 16-23, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24087893

RESUMO

OBJECTIVE: There are few studies regarding assessment and treatment of trauma-related disorders in people with intellectual disabilities (ID). The aims of this study were to determine (1) the feasibility of an adapted version of a post-traumatic stress disorder (PTSD)-clinical interview and (2) to what extent manifestation of PTSD in a sample of children with mild to borderline ID corresponds with four existing PTSD algorithms. METHOD: Fifteen children who visited a special need school were interviewed. RESULTS: In all children, the full interview could be completed. Potentially traumatic events (A1 criterion), and PTSD symptoms for children with mild to borderline ID were similar to those observed in children without ID. CONCLUSIONS: The manifestation of PTSD in children with mild to borderline ID corresponds with the manifestation of PTSD in children without ID. The data provide no reason to broaden PTSD criterion A1 for children with mild to borderline ID.


Assuntos
Deficiência Intelectual/psicologia , Transtornos de Estresse Pós-Traumáticos/diagnóstico , Atividades Cotidianas , Adolescente , Criança , Estudos de Viabilidade , Feminino , Humanos , Masculino , Projetos Piloto , Transtornos de Estresse Pós-Traumáticos/terapia , Resultado do Tratamento
17.
J Autism Dev Disord ; 43(12): 2990-6, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23624879

RESUMO

The present study aims at examining whether the 'Social Skills Performance Assessment' (SSPA; Patterson et al. in Schizophr Res 48(2-3):351-360, 2001) is a suitable performance-based measure to assess social skills in adults with autism spectrum disorders (ASD). For this purpose, social skills of individuals with ASD and non-ASD participants were assessed through the SSPA role plays. Results of this study suggest that the SSPA is suitable for the assessment of social skills in adults with ASD. The SSPA discriminates between individuals with ASD and non-ASD individuals, with the ASD group scoring significantly lower. Although no evidence was found for convergent validity of the SSPA in participants with ASD, divergent validity of the SSPA and interrater reliability among adults with ASD were good.


Assuntos
Transtornos Globais do Desenvolvimento Infantil/psicologia , Determinação da Personalidade , Comportamento Social , Adolescente , Adulto , Feminino , Humanos , Masculino , Reprodutibilidade dos Testes , Adulto Jovem
18.
J Intellect Disabil Res ; 57(11): 993-1000, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22823064

RESUMO

BACKGROUND: In some of our patients with intellectual disabilities (ID) and sleep problems, the initial good response to melatonin disappeared within a few weeks after starting treatment. In these patients melatonin levels at noon were extremely high (>50 pg/ml). We hypothesise that the disappearing effectiveness is associated with slow metabolisation of melatonin because of a single nucleotide polymorphism (SNP) of CYP1A2. METHOD: In this pilot study we analysed DNA extracted from saliva samples of 15 consecutive patients with disappearing effectiveness of melatonin. Saliva was collected at noon and 4 pm for measuring melatonin levels. RESULTS: In all patients' salivary melatonin levels at noon were >50 or melatonin half time was > 5 h. A SNP was found in eight of 15 patients. The allele 1C was found in two patients and in six patients the 1F allele was found. CONCLUSIONS: Of 15 patients with disappearing effectiveness of melatonin, seven were diagnosed with autism spectrum disorder, and in four of them a SNP was found. The other eight patients were known with a genetic syndrome. In six of them behaviour was considered to be autistic-type and in three of them a SNP was found. This finding may give a new direction for research into the genetic background of autism.


Assuntos
Transtornos Globais do Desenvolvimento Infantil/genética , Citocromo P-450 CYP1A2/genética , Melatonina/metabolismo , Polimorfismo Genético , Distúrbios do Início e da Manutenção do Sono/genética , Adolescente , Adulto , Transtorno Autístico/genética , Transtorno Autístico/metabolismo , Criança , Transtornos Globais do Desenvolvimento Infantil/metabolismo , Pré-Escolar , Citocromo P-450 CYP1A2/metabolismo , Feminino , Humanos , Masculino , Projetos Piloto , Saliva/metabolismo , Distúrbios do Início e da Manutenção do Sono/metabolismo
19.
J Intellect Disabil Res ; 56(5): 546-65, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22221562

RESUMO

BACKGROUND: The Behavior Problems Inventory-01 (BPI-01) is an informant-based behaviour rating instrument for intellectual disabilities (ID) with 49 items and three sub-scales: Self-injurious Behavior, Stereotyped Behavior and Aggressive/Destructive Behavior. The Behavior Problems Inventory-Short Form (BPI-S) is a BPI-01 spin-off with 30 items. METHODS: The psychometric properties of these two versions of the scale were computed using aggregated archival data from nine different sites in the USA, Wales, England, the Netherlands and Romania with a total of 1122 cases with a BPI-01 total score >0. RESULTS: The internal consistency of the BPI-01 and the BPI-S ranged from fair to excellent with the BPI-01 showing slightly stronger reliability. Construct validity (confirmatory and discriminant) was computed by comparing BPI sub-scale scores with the scores of four other behaviour rating scales (the Aberrant Behavior Checklist, the Diagnostic Assessment for the Severely Handicapped-II, the Nisonger Child Behavior Rating Form and the Inventory for Client and Agency Planning). Strong evidence for confirmatory and discriminant validity was found for both the BPI-01 and the BPI-S. Confirmatory fit indices for the BPI and the BPI-S were comparable and suggesting that the factor structures fit the data well. CONCLUSION: In summary, both BPI versions were found to be equally sound psychometrically and can be endorsed for future use. However, independent future studies are needed to replicate the psychometrics of the BPI-S with new data.


Assuntos
Deficiência Intelectual/diagnóstico , Deficiência Intelectual/psicologia , Inventário de Personalidade/normas , Psicometria/normas , Comportamento Autodestrutivo/diagnóstico , Comportamento Autodestrutivo/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Agressão , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/diagnóstico , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/epidemiologia , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/psicologia , Criança , Comportamento Infantil , Pré-Escolar , Feminino , Humanos , Deficiência Intelectual/epidemiologia , Masculino , Pessoa de Meia-Idade , Inventário de Personalidade/estatística & dados numéricos , Psicometria/estatística & dados numéricos , Reprodutibilidade dos Testes , Comportamento Autodestrutivo/epidemiologia , Índice de Gravidade de Doença , Transtorno de Movimento Estereotipado/diagnóstico , Transtorno de Movimento Estereotipado/epidemiologia , Transtorno de Movimento Estereotipado/psicologia , Adulto Jovem
20.
J Intellect Disabil Res ; 56(5): 527-45, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22151184

RESUMO

BACKGROUND: The Behavior Problems Inventory-01 (BPI-01) is an informant-based behaviour rating instrument that was designed to assess maladaptive behaviours in individuals with intellectual disabilities (ID). Its items fall into one of three sub-scales: Self-injurious Behavior (14 items), Stereotyped Behavior (24 items), and Aggressive/Destructive Behavior (11 items). Each item is rated on a frequency scale (0 = never to 4 = hourly), and a severity scale (0 = no problem to 3 = severe problem). The BPI-01 has been successfully used in several studies and has shown acceptable to very good psychometric properties. One concern raised by some investigators was the large number of items on the BPI-01, which has reduced its user friendliness for certain applications. Furthermore, researchers and clinicians were often uncertain how to interpret their BPI-01 data without norms or a frame of reference. METHODS: The Behavior Problems Inventory-Short Form (BPI-S) was empirically developed, based on an aggregated archival data set of BPI-01 data from individuals with ID from nine locations in the USA, Wales, England, the Netherlands, and Romania (n = 1122). The BPI-S uses the same rating system and the same three sub-scales as the BPI-01, but has fewer items: Self-injurious Behavior (8 items), Stereotyped Behavior (12 items), and Aggressive/Destructive Behavior (10 items). Rating anchors for the severity scales of the Self-injurious Behavior and the Aggressive/Destructive Behavior sub-scales were added in an effort to enhance the objectivity of the ratings. RESULTS: The sensitivity of the BPI-S compared with the BPI-01 was high (0.92 to 0.99), and so were the correlations between the analogous BPI-01 and the BPI-S sub-scales (0.96 to 0.99). Means and standard deviations were generated for both BPI versions in a Sex-by-age matrix, and in a Sex-by-ID Level matrix. Combined sex ranges are also provided by age and level of ID. CONCLUSION: In summary, the BPI-S is a very useful alternative to the BPI-01, especially for research and evaluation purposes involving groups of individuals.


Assuntos
Deficiência Intelectual/diagnóstico , Deficiência Intelectual/psicologia , Inventário de Personalidade/normas , Comportamento Autodestrutivo/diagnóstico , Comportamento Autodestrutivo/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Agressão/psicologia , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/diagnóstico , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/epidemiologia , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/psicologia , Criança , Pré-Escolar , Feminino , Humanos , Deficiência Intelectual/epidemiologia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Inventário de Personalidade/estatística & dados numéricos , Prevalência , Valores de Referência , Comportamento Autodestrutivo/epidemiologia , Sensibilidade e Especificidade , Transtorno de Movimento Estereotipado/diagnóstico , Transtorno de Movimento Estereotipado/epidemiologia , Transtorno de Movimento Estereotipado/psicologia , Adulto Jovem
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