RESUMO
A novel protocol for nickel-catalyzed direct sp(2) C-H bond alkylation of N-aromatic heterocycles has been developed. This new reaction proceeded efficiently at room temperature using a Grignard reagent as the coupling partner. This approach provides new access to a variety of alkylated N-aromatic heterocycles which are potentially of great importance in medicinal chemistry.
Assuntos
Compostos Heterocíclicos/química , Níquel/química , Alquilação , Catálise , Estrutura MolecularRESUMO
In the title mol-ecule, C(30)H(36)N(2)O(2), the dihedral angles between the central benzene ring and the two benzene rings of the butyl-salicylaldimine groups are 14.3â (2) and 40.6â (2)°. There are two strong intra-molecular O-Hâ¯N hydrogen bonds which form S(6) rings. The crystal studied was a non-merohedral twin with refined components of 0.270â (4) and 0.730â (4).
RESUMO
In the title complex, [Sn(C(2)H(2)ClO(2))(2)(C(4)H(11)Si)(2)], the Sn(IV) ion is coordinated in a distorted tetra-hedral environment formed by two O atoms from two monodenate chloro-acetato ligands and two C atoms from two trimethyl silyl ligands. Two further weak intra-molecular Snâ¯O contacts [2.744â (2) and 2.655â (2)â Å] are formed by the chloro-acetato ligands.
RESUMO
A novel protocol for nickel-catalyzed direct sp(2) C-H bond arylation of purines has been developed. This new reaction proceeded efficiently at room temperature using Grignard reagent as the coupling partner within 5 hours in good to high yields. This approach provides a new access to a variety of C8-arylpurines which are potentially of great importance in medicinal chemistry.