RESUMO
Lactococcus lactis subsp. lactis NCDO 2118 is a nondairy lactic acid bacterium, a xylose fermenter, and a gamma-aminobutyric acid (GABA) producer isolated from frozen peas. Here, we report the complete genome sequence of L. lactis NCDO 2118, a strain with probiotic potential activity.
RESUMO
Corynebacterium pseudotuberculosis is the causative agent of several veterinary diseases in a broad range of economically important hosts, which can vary from caseous lymphadenitis in sheep and goats (biovar ovis) to ulcerative lymphangitis in cattle and horses (biovar equi). Existing vaccines against C. pseudotuberculosis are mainly intended for small ruminants and, even in these hosts, they still present remarkable limitations. In this study, we present the complete genome sequence of C. pseudotuberculosis biovar equi strain 258, isolated from a horse with ulcerative lymphangitis. The genome has a total size of 2,314,404 bp and contains 2088 predicted protein-coding regions. Using in silico analysis, eleven pathogenicity islands were detected in the genome sequence of C. pseudotuberculosis 258. The application of a reverse vaccinology strategy identified 49 putative antigenic proteins, which can be used as candidate vaccine targets in future works.
Assuntos
Antígenos de Bactérias/genética , Vacinas Bacterianas/biossíntese , Vacinas Bacterianas/imunologia , Biotecnologia/métodos , Corynebacterium pseudotuberculosis/genética , Corynebacterium pseudotuberculosis/imunologia , Doenças dos Animais/imunologia , Doenças dos Animais/microbiologia , Doenças dos Animais/prevenção & controle , Animais , Antígenos de Bactérias/imunologia , Antígenos de Bactérias/metabolismo , Vacinas Bacterianas/genética , Sequência de Bases , Infecções por Corynebacterium/microbiologia , Infecções por Corynebacterium/prevenção & controle , Infecções por Corynebacterium/veterinária , Corynebacterium pseudotuberculosis/metabolismo , Genoma Bacteriano , Ilhas Genômicas , CavalosRESUMO
Here, we report the whole-genome sequences of two ovine-pathogenic Corynebacterium pseudotuberculosis isolates: strain 3/99-5, which represents the first C. pseudotuberculosis genome originating from the United Kingdom, and 42/02-A, the second from Australia. These genome sequences will contribute to the objective of determining the global pan-genome of this bacterium.
Assuntos
Infecções por Corynebacterium/veterinária , Corynebacterium pseudotuberculosis/genética , Genoma Bacteriano , Doenças dos Ovinos/microbiologia , Animais , Austrália , Sequência de Bases , Mapeamento Cromossômico , Infecções por Corynebacterium/microbiologia , Corynebacterium pseudotuberculosis/classificação , Corynebacterium pseudotuberculosis/isolamento & purificação , Linfadenite/microbiologia , Linfadenite/veterinária , Dados de Sequência Molecular , Escócia , Análise de Sequência de DNA , Ovinos/microbiologiaRESUMO
Corynebacterium pseudotuberculosis causes disease in several animal species, although distinct biovars exist that appear to be restricted to specific hosts. In order to facilitate a better understanding of the differences between biovars, we report here the complete genome sequence of the equine pathogen Corynebacterium pseudotuberculosis strain 1/06-A.
