Direct gamma dose rate measurement and assessment of excess lifetime cancer risk.

In this study, in some neighborhoods in Kahramanmaras province of Turkey, indoors and outdoors direct gamma dose rate measurements have been done. All of the gamma dose rate measurements have been made at ground level and at the height of 1 m from the ground. The median values of the gamma dose rates on the ground and 1 m above the ground indoors are 70.34 ± 7.74 and 49.53 ± 5.39 nGy h-1, respectively. Outdoor measurements have been carried out on both soil and asphalt floors. The average values of gamma dose rate on the ground and at a height of 1 m outdoors (soil floor) are 68.16 ± 7.49 and 53.50 ± 5.88 nGy h-1, respectively. The mean values of gamma dose rate on the ground and 1 m above the ground outdoors (asphalt floor) are 61.63 ± 6.77 and 48.69 ± 5.35 nGy h-1, respectively. Indoor and outdoor average gamma dose rates are below the mean world. In addition, using the measured gamma dose rate values, annual effective dose equivalent (AEDE) and excess lifetime cancer risk (ELCR) for adults have been calculated. The total AEDE and ELCR (on soil floors and indoors at 1 m above ground level) are 0.31 ± 0.03 mSv y-1 and 1.08 ± 0.10 × 10-3, respectively. The total AEDE and ELCR (on asphalt floors and indoors at 1 m above ground level) are 0.30 ± 0.03 mSv y-1 and 1.06 ± 0.10 × 10-3, respectively. The AEDE and ELCR for adults living in the neighborhoods within the scope of the study in Kahramanmaras city center within 1 y are lower than the average world.

Natural radioactivity in soil samples taken from Kahramanmaras provincial center.

The levels of 238U, 232Th, and 40K with gross alpha and beta values in soils collected from the Kahramanmaras city center were measured in this study, and the annual effective dose equivalent (AEDE), excessive lifetime cancer risk (ELCR), and terrestrial absorbed gamma dose rates were calculated for gamma radiation from 238U, 232Th, and 40K radionuclides. The samples' gross alpha and beta radioactivity concentrations, respectively, range from 0.06 ± 0.01 Bq/kg to 0.45 ± 0.04 Bq/kg and 0.14 ± 0.02 Bq/kg to 0.95 ± 0.09 Bq/kg. The Kahramanmaras province's soil samples have mean gross alpha and beta radiation values of 0.25 ± 0.03 Bq/kg and 0.52 ± 0.05 Bq/kg, respectively. 238U, 232Th, and 40K activity concentrations in soil samples range from 2.32 ± 0.2 Bq/kg to 40.10 ± 1.4 Bq/kg, 0.60 ± 0.03 Bq/kg to 10.47 ± 1.01 Bq/kg, and 11.60 ± 1.01 Bq/kg to 160.84 ± 4.6 Bq/kg, respectively. 238U, 232Th, and 40K each had average activity concentrations of 11.50 ± 1.1, 4.50 ± 0.4, and 62.20 ± 1.6 Bq/kg in soil, respectively. The annual effective dose equivalent (AEDE), excessive lifetime cancer risk (ELCR), and terrestrial absorbed gamma dose rate range from 0.01 ± 0.01 µSv y-1 to 0.03 ± 0.02 µSv y-1, and 0.01 ± 0.01 × 10-3 to 0.12 ± 0.03 × 10-3, 1.72 ± 0.01 nGy h-1 to 25.05 ± 0.21 nGy h-1, respectively. Additionally, the average annual effective dose equivalent (AEDE), average excessive lifetime cancer risk (ELCR), and average terrestrial absorbed gamma dose rates are 0.01 ± 0.01 µSv y-1, and 0.05 ± 0.02 × 10-3, 9.81 ± 0.09 nGy h-1, respectively. The acquired data were compared to both domestic and international standards.

Radioactivity amounts, annual effective dose rate, and lifetime cancer risk estimation of some vegetable and fruit samples cultivated in Kahramanmaras, Turkey.

In this research, examples of the fruits and vegetables cultivated in Kahramanmaras, 238U, 232Th, and 40K levels, were detected, and in the case of consumption of these vegetables and fruits, for several age categories (adults, children (10 years old), and infants), annually effective dose rates and lifetime cancer risks were calculated. In fruit samples, concentrations of 238U, 232Th, and 40K ranged from under detection limit (UDL) to 15.29 ± 1.14 Bq/kg, 0.30 ± 0.01 to 13.23 ± 1.60 Bq/kg, and 5.82 ± 0.21 to 179.82 ± 1.34 Bq/kg, respectively. The mean concentrations of 238U, 232Th, and 40K in fruit samples were 5.31 ± 0.44 Bq/kg, 2.72 ± 0.26 Bq/kg, and 56.84 ± 0.57 Bq/kg, respectively. In vegetable samples, concentrations of 238U, 232Th, and 40K ranged from 0.48 ± 0.04 to 11.77 ± 0.95 Bq/kg, 0.55 ± 0.04 to 4.57 ± 0.44 Bq/kg, and 9.32 ± 0.43 to 52.44 ± 0.52 Bq/kg, respectively. The mean concentrations of 238U, 232Th, and 40K in the vegetable samples were 6.58 ± 0.65 Bq/kg, 2.72 ± 0.27 Bq/kg, and 27.09 ± 0.27 Bq/kg, respectively. The mean annual effective dose rates for adults, children (10 years old), and infants in fruit samples were 0.184 ± 0.001 mSv/y, 0.288 ± 0.002 mSv/y, and 0.304 ± 0.003 mSv/y, respectively. The average lifetime cancer risks for adults, children (10 years old), and infants in fruit samples were 0.647 ± 0.006 × 10-4, 1.011 ± 0.010 × 10-4, and 1.067 ± 0.010 × 10-4, respectively. The mean annual effective dose rates for adults, children (10 years old), and infants in the vegetable samples were 0.118 ± 0.001 mSv/y, 0.128 ± 0.001 mSv/y, and 0.086 ± 0.001 mSv/y, respectively. The mean lifetime cancer risks for adults, children (10 years old), and infants in vegetable samples were 0.416 ± 0.004 × 10-4, 0.449 ± 0.004 × 10-4, and 0.304 ± 0.003 × 10-4, respectively.

Evaluation of the Early Effects of Childhood Asthma and Its Treatment on Cardiac Function as Revealed by Two-Dimensional Speckle-Tracking Echocardiography.

There is minimal information available regarding the early effects of bronchial asthma (BA) and its treatment on cardiac function in children. We used two-dimensional speckle-tracking echocardiography (2D-STE) to evaluate cardiac function before and after the treatment of childhood BA. We enrolled 44 children with moderate and severe BA who had not been treated over the preceding 3 months or who were newly diagnosed. All children received the same treatment (that recommended by the Global Initiative for Asthma [GINA] in 2017). All children also underwent transthoracic 2D-STE before treatment and 6 months later. Clinical data were compared before and after treatment. After treatment, significant increases were evident in right ventricular (RV) systolic and diastolic strain, as well as the systolic strain rate. Before and after treatment, the RV global longitudinal systolic strains were - 22.8 ± 3.6 and - 25.1 ± 4.5, respectively (p = 0.036); the RV global longitudinal diastolic strains were - 18.5 ± 6.0 and - 21.5 ± 5.2, respectively (p = 0.038); and the RV systolic strain rates were - 1.26 ± 0.4 and - 1.12 ± 0.3, respectively (p = 0.025). After treatment, significant increases were observed in the right atrial (RA) peak longitudinal strain and strain rate. Before and after treatment, the RA peak atrial longitudinal strains were 32.5 ± 10.8 and 44.7 ± 11.2, respectively (p = 0.042) and the RA longitudinal strain rates were - 1.6 ± 0.3 and - 2.0 ± 0.5, respectively (p = 0.041). RV and RA subclinical dysfunction may develop in children with early-stage BA. However, asthma treatment appears to improve such dysfunction. In children with BA, clinical and subclinical changes in cardiac functions can be easily detected via 2D-STE.

Does Sugammadex Suppress Allergic Inflammation Due to Rocuronium in Animal Model of Rat?

INTRODUCTION AND OBJECTIVES: There are a few reports in the literature about the successful use of sugammadex in the treatment of hypersensitivity reactions caused by rocuronium; however, the pathophysiological mechanism is still unknown. This study aims to investigate the changes caused by rocuronium in the lung and the effect of sugammadex on these changes with biochemical, light microscopic and immunohistochemical parameters on a rat model. MATERIALS AND METHODS: For the study, 28-male Sprague-Dawley rats were randomly divided, seven of each, into four groups. Group C (control) received only 0. 9 % NaCl without any drug. Group R received rocuronium alone 1mg/kg. Group S received sugammadex alone 96 mg/kg. Group RS received rocuronium 1mg/kg and sugammadex 96 mg/kg. After 24 h later, the animals were sacrificed and their tissues were removed. Biochemical (IgE/CRP), light microscopic and immunohistochemical findings were recorded. RESULTS: Immunoglobulin E and CRP levels, peribronchial, alveolar septal lymphocytic infiltration, thickening of the alveolar membranes and bleeding sites in Group R were significantly higher than all the other groups. In Group RS, while these parameters were significantly lower than that of Group R and Group S, it was significantly higher than that of Group C. Total mast cells and tryptase-positive mast cells counts were significantly higher in Group R than in all other groups. In Group RS, these parameters were statistically lower than that of Group R and Group S, but higher than that of Group C. CONCLUSIONS: This study shows that allergic inflammatory changes due to rocuronium in the lungs of rats are reduced with sugammadex. These results support cases of anaphylaxis due to rocuronium which improved with sugammadex.

Investigation of radioactivity concentration of 137Cs, 90Sr and 129I radioisotopes in thyroid samples.

In this study, the gross alpha and beta activities and 137Cs, 90Sr and 129I radionuclide concentrations in the feeds and thyroid samples obtained from a certain number of sheep, which were fed by Firat University (Elazig) Faculty of Veterinary Medicine with varying amounts of fresh lucerne, fodder, silage, straw and concentrate feed were determined. The 137Cs, 90Sr and 129I radionuclide transfer coefficients were also determined. 90Sr and 129I are beta-emitting radionuclides. Sheep with high 90Sr and 129I radionuclide concentrations also have high gross beta radioactivity levels. When an intragroup comparison is performed, the radionuclide concentration in a sheep fed with maximum feed is at the highest level and vice versa. Moreover, the 137Cs, 90Sr and 129I radionuclide transfer coefficients (Ff) for the thyroid samples obtained from the sheep vary between 0.4 × 10-1 - 8.1 × 10-1 d kg-1, 0.4 × 10-2 - 6.1 × 10-1 d kg-1 and 0.4 × 10-1 - 7.3 × 10-1 d kg-1, respectively, and are higher than the expected Ff values and the results obtained in similar studies. The Ff values calculated for the thyroid samples of the straw and fodder group are lower than the Ff values calculated for the thyroid samples of the silage and fresh lucerne group. The radionuclide concentrations for 129I were found to be higher than 90Sr's in the thyroid samples.

Effects of modifying visual inhaler spacer usage instructions on correct usage rate of untrained users.

BACKGROUND: Pressurized metered-dose inhalers (pMDIs) used with spacers are considered the method of choice for delivery of inhaled drugs in preschool-age children. The aim of this study was to determine the effects of modifying the visual inhaler spacer usage guidelines on the correct usage rate. METHODS: The parents and caregivers of patients <6 years old who were prescribed inhalers with spacers for the first time were included in our study. The participants were randomly divided into a modified visual inhaler spacer usage guidelines group and an unmodified visual inhaler spacer usage guidelines group. All study participants underwent face-to-face interviews and completed questionnaires. RESULTS: A total of 510 participants with a median age of 31 (range, 20-46) years were included in this study. The modified visual guidelines group included 254 (49.6%) participants, and the unmodified visual guidelines group included 256 (50.4%) participants. One hundred sixty-five (65.2%) of the 254 participants in the modified visual guidelines group correctly demonstrated the inhaler spacer technique. In contrast, only 21 (8.2%) of the 256 participants in the unmodified visual guidelines group correctly demonstrated the inhaler spacer technique (p < 0.001). When comparing the inhaler spacer usage steps between the 2 groups, the modified visual guidelines group demonstrated the steps more correctly and more quickly (p < 0.001). CONCLUSION: The current visual inhaler spacer usage guidelines are insufficient. We believe that improving the visual inhaler spacer usage guidelines, in particular, will increase the correct usage rate and decrease the number of usage errors.

Swept-source optical coherence tomography analysis in asthmatic children under inhaled corticosteroid therapy.

PURPOSE: To evaluate retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), subfoveal choroidal thickness (SFCT), and central retinal thickness (CRT) in asthmatic children who were under inhaled corticosteroid treatment by using Swept-Source Optical Coherence Tomography (SS-OCT). MATERIAL AND METHODS: Fifty-three children were prospectively analyzed in the study. Group 1 included 31 asthmatic children and group 2 included 22 healthy children. Asthmatic children received a dose 250 µg daily of inhaled fluticasone propionate (Flexotide, GlaxoSmithKline, Middlesex, UK). Allergy parameters including, exposure to smoke, eosinophil count, percentage of eosinophils, immunoglobuline (Ig) E levels, number of asthma attacks, number of sensitivity to allergens and follow-up time were recorded. The RNFLT, GCLT, SFCT, and CRT were analyzed with SS-OCT and the data were compared between the groups. RESULTS: There were 13 girls (41.9%) and 18 boys (58.1%) in group 1 and 13 girls (59.1%) and 9 boys (40.9%) in group 2 (p = 0.22). The mean age was 9.3 ± 2.2 years in group 1 and 9.9 ± 1.5 years in group 2 (p = 0.08). The mean CRT (239.26 ± 34.56 µm versus 226.82 ± 26.23 µm, p = 0.22) and mean SFCT (273.97 ± 40.95 µm versus 280.41 ± 32.78 µm, p = 0.54) did not significantly differ between the groups. The superior, inferior, and average RNFLT were significantly lower in group 1 than group 2 (p < 0.05). There were significant correlations between total corticosteroid dose and RNFLT (p < 0.05) and between IgE levels and GCLT (p < 0.05). CONCLUSIONS: The SS-OCT revealed that asthmatic children under inhaled corticosteroid treatment have lower RNFLT than healthy subjects.

Subclinical right ventricular dysfunction in intermittent and persistent mildly asthmatic children on tissue Doppler echocardiography and serum NT-proBNP: Observational study.

BACKGROUND: Bronchial asthma may lead to pulmonary hypertension, right ventricular (RV) dysfunction, and cor pulmonale due to elevated afterload on the RV later in life. The aim of this study was to determine whether serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) might serve as a biomarker for detecting subclinical RV dysfunction using echocardiography during the early stages of bronchial asthma. METHODS: Sixty-eight pediatric patients with asthma (asthma group) and 69 age- and sex-matched healthy children (control group) were enrolled. The study was conducted in a tertiary woman and child diseases education and research hospital from January 2013 to December 2013. RV function (2-D and tissue-Doppler echocardiography), pulmonary function (spirometry) and serum NT-proBNP concentration were evaluated. RESULTS: Mean age was 10.5 ± 2.8 years in the asthma group and 10.2 ± 2.7 years in the control group (P = 0.522). RV diastolic function was significantly decreased in the asthma group (ratio of tricuspid lateral annular early diastolic peak velocity to tricuspid lateral annular late diastolic peak velocity [E'/A'], 1.29 ± 0.68 vs 1.74 ± 0.89, P = 0.001). RV myocardial performance index was significantly higher in the asthma group than in the control group (0.28 ± 0.06 vs 0.24 ± 0.07, respectively; P = 0.003). Finally, serum NT-proBNP concentration was significantly higher in the asthma group than in the control group (292.3 ± 142.2 pg/mL vs 208.2 ± 70.1 pg/mL, respectively; P = 0.003). CONCLUSION: Increased serum NT-proBNP is associated with subclinical RV dysfunction in asthmatic children. RV function is significantly affected in children with bronchial asthma.

Concentraciones de albúmina modificada por la isquemia en niños con asma: estudio piloto / Ischemia-modified albumin levels in children with asthma: a pilot study

Introducción. La albúmina modificada por la isquemia puede aumentar en el asma (IMA), estrés oxidativo y la inflamación. El objetivo fue evaluar las concentraciones de IMA en niños asmáticos durante períodos asintomáticos y de exacerbación. Población y métodos. Niños asmáticos y sanos en seguimiento (grupo de referencia). La gravedad de la exacerbación se evaluó mediante la Iniciativa global para el asma (GINA) y la puntuación del índice pulmonar modificado (MPIS). Se usaron pruebas intraepidérmicas y de proteína C reactiva para medir las concentraciones séricas de IMA durante la exacerbación y 4 semanas después del tratamiento. Resultados. Participaron 26 pacientes y 26 controles. Las concentraciones medias de IMA durante la exacerbación (0,45 ± 0,12 ABSU) y durante el período de estabilidad (0,41 ± 0,14 ABSU) fueron mayores que en los niños sanos (0,32 ± 0,08 ABSU): p= 0,001 y p= 0,005, respectivamente. No hubo diferencias en IMA al agrupar a los pacientes por tratamiento antiinflamatorio, infección de las vías respiratorias altas previa a la exacerbación, concentraciones de PCR o sensibilidad a las pruebas intraepidérmicas. Las concentraciones fueron más elevadas en los pacientes con exacerbación grave que leve/moderada (p= 0,009). La correlación entre IMA y la gravedad de la exacerbación (r: 0,498; p= 0,010) fue positiva. Conclusiones. Los niños asmáticos presentaron concentraciones de IMA más elevadas que el grupo de referencia, tanto en el período de estabilidad como durante la exacerbación. Hubo una relación positiva entre las concentraciones de IMA y la gravedad de la exacerbación.

Introduction: Hypoxia may occur in the severe exacerbations of asthma. Ischemia-modified albumin (IMA) may increase in ischemia, in addition to oxidative stress and inflammation. The aim was to evaluate IMA levels in children during the asthma exacerbation and the asymptomatic period. Populations and methods: Children with asthma who were followed up in our clinic were included and healthy children were selected as the control group. The severity of exacerbation was evaluated with Global Initiative for Asthma and Modified Pulmonary Index Score. Serum IMA levels were measured at the time of exacerbation and 4 weeks after treatment during asymptomatic period. Skin prick test and C reactive protein (CRP) levels were measured. Results: A total of 26 patients and 26 controls were included. Mean IMA level was 0.45+0.12 absorbance units -ABSU- during asthma exacerbation and 0.32+0.08 ABSU in the control group (p=0.001). Mean IMA levels (0.41+0.14 ABSU) during the stable period were higher than the control group (p=0.005). There was no difference in terms of IMA levels when patients were grouped according to anti-inflammatory treatment, upper respiratory tract infection before exacerbation, CRP levels or sensitivity of skin prick tests. However, IMA levels were higher in patients with severe asthma exacerbation (p=0.009) in comparison with mild/moderate exacerbation. Positive correlation was observed between IMA levels and severity of exacerbation (r: 0.498, p=0.010). Conclusions: Asthmatic children had higher IMA levels than the control group, both in stable and exacerbated asthma. There was a positive relationship between IMA levels and severity of asthma exacerbation.

Ischemia-modified albumin levels in children with asthma: a pilot study. / Concentraciones de albúmina modificada por la isquemia en niños con asma: estudio piloto.

INTRODUCTION: Hypoxia may occur in the severe exacerbations of asthma. Ischemia-modified albumin (IMA) may increase in ischemia, in addition to oxidative stress and inflammation. The aim was to evaluate IMA levels in children during the asthma exacerbation and the asymptomatic period. POPULATION AND METHODS: Children with asthma who were followed up in our clinic were included and healthy children were selected as the control group. The severity of exacerbation was evaluated with Global Initiative for Asthma and Modified Pulmonary Index Score. Serum IMA levels were measured at the time of exacerbation and 4 weeks after treatment during asymptomatic period. Skin prick test and C reactive protein (CRP) levels were measured. RESULTS: A total of 26 patients and 26 controls were included. Mean IMA level was 0.45±0.12 absorbance units -ABSU- during asthma exacerbation and 0.32±0.08 ABSU in the control group (p=0.001). Mean IMA levels (0.41±0.14 ABSU) during the stable period were higher than the control group (p=0.005). There was no difference in terms of IMA levels when patients were grouped according to anti-inflammatory treatment, upper respiratory tract infection before exacerbation, CRP levels or sensitivity of skin prick tests. However, IMA levels were higher in patients with severe asthma exacerbation (p=0.009) in comparison with mild/moderate exacerbation. Positive correlation was observed between IMA levels and severity of exacerbation (r: 0.498, p=0.010). CONCLUSIONS: Asthmatic children had higher IMA levels than the control group, both in stable and exacerbated asthma. There was a positive relationship between IMA levels and severity of asthma exacerbation.

Introducción. La albúmina modificada por la isquemia puede aumentar en el asma (IMA), estrés oxidativo y la inflamación. El objetivo fue evaluar las concentraciones de IMA en niños asmáticos durante períodos asintomáticos y de exacerbación. Población y métodos. Niños asmáticos y sanos en seguimiento (grupo de referencia). La gravedad de la exacerbación se evaluó mediante la Iniciativa global para el asma (GINA) y la puntuación del índice pulmonar modificado (MPIS). Se usaron pruebas intraepidérmicas y de proteína C reactiva para medir las concentraciones séricas de IMA durante la exacerbación y 4 semanas después del tratamiento. Resultados. Participaron 26 pacientes y 26 controles. Las concentraciones medias de IMA durante la exacerbación (0,45 ± 0,12 ABSU) y durante el período de estabilidad (0,41 ± 0,14 ABSU) fueron mayores que en los niños sanos (0,32 ± 0,08 ABSU): p= 0,001 y p= 0,005, respectivamente. No hubo diferencias en IMA al agrupar a los pacientes por tratamiento antiinflamatorio, infección de las vías respiratorias altas previa a la exacerbación, concentraciones de PCR o sensibilidad a las pruebas intraepidérmicas. Las concentraciones fueron más elevadas en los pacientes con exacerbación grave que leve/moderada (p= 0,009). La correlación entre IMA y la gravedad de la exacerbación (r: 0,498; p= 0,010) fue positiva. Conclusiones. Los niños asmáticos presentaron concentraciones de IMA más elevadas que el grupo de referencia, tanto en el período de estabilidad como durante la exacerbación. Hubo una relación positiva entre las concentraciones de IMA y la gravedad de la exacerbación.

Radioactivity and hydrochemical properties of certain thermal Turkish spa waters.

The study aims to determine the radioactivity levels of thermal waters which have been used seasonally or permanently in spas for therapeutic intentions. Samples were collected from spas in different regions of Turkey. Some radionuclides (40K, 232Th, 226Ra, 137Cs), gross alpha (GA) and gross beta (GB) activities, and physical and some chemical parameters were measured. Gamma radiation measurements for 226Ra, 232Th and 40K radionuclides were performed by using a high purity germanium (HPGe) detector. The results of the gamma spectrometry ranged from 1.385 to 11.025 Bql-1 for 226Ra,

Radioactivity analysis of soil samples taken from the western and northern shores of Lake Van, Turkey.

In this study, concentrations of the radioactive isotopes 226Ra, 232Th, 40K and 137Cs were measured in soil samples from the shores of Lake Van using a high purity germanium detector. Activity concentrations obtained for these nuclides were compared with world average values. The average 226Ra, 232Th and 40K activity concentrations calculated for the soil samples were higher than the world average values reported by UNSCEAR. The lowest 226Ra, 232Th and 40K activity concentrations were recorded in sample T-1 whereas the highest values were recorded in sample T-11. Concentrations of 137C in the samples ranged between 0.91 ± 0.01 and 29.68 ± 0.33Bqkg-1. In order to evaluate the radiological hazards resulting from natural radioactivity, radium equivalent activities, absorbed dose rates, and internal and external hazard indices were calculated and the results were compared with internationally recognized values.

Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?

Our study aims to evaluate the presence of adenoid hypertrophy (AH) in children with allergic rhinitis (AR) and the association of AH disease severity and clinical laboratory finding from retrospective, cross-sectional, and nonrandomized trial. The study included 566 children being treated and followed up for allergic rhinitis. Skin prick test for the same allergens was performed for all patients. Adenoid tissue was analyzed by an ENT specialist and the diagnosis was confirmed based on the patient history, endoscopic physical examination and radiology. Adenoid hypertrophy was detected in 118 (21.2 %) of the children with AR. Children with and without AH did not differ statistically and significantly by gender, age, presence of atopy in the family, exposure to smoke (p > 0.05). Comparison of the groups for AR duration demonstrated significantly higher frequency of persistent rhinitis in patients with AH (p < 0.05). Of the AR patients with AH, 90 (76.3 %) had moderate-severe rhinitis and 274 (62.6 %) AR patients without AH had moderate-severe rhinitis (p = 0.005). Itchy nose was more frequent in AR patients without AH, and nasal congestion was more common in AR patients with AH (p = 0.017 and p = 0.001, respectively). The presence of asthma was more common among AR patients without AH (p = 0.037). Intergroup comparisons for presence of atopic dermatitis, the percentage of eosinophil, serum IgE levels, the number of positive sensitivity, polysensitization, sensitivity to house dust mite, cockroach, pollens and dander yielded no significant difference (p > 0.05). On the other hand, sensitivity to Alternaria alternata was significantly more frequent in AR patients with AH (p = 0.032). The presence of AH increased the severity of the disease and prolongs disease duration. There was a negative relationship between AH and asthma in children with AR. AH is more common among children with mold sensitivity. AH should be considered and investigated particularly in non-asthmatic children with pronounced nasal congestion and A. alternata sensitivity.

The Relevance of Nasal Provocation Testing in Children with Nonallergic Rhinitis.

BACKGROUND: It is important to understand that allergic rhinitis, whether seasonal or perennial, may be difficult to distinguish clinically from the nonallergic forms of rhinitis. OBJECTIVE: This study aimed to investigate the presence of local allergic rhinitis (LAR) in children who have allergic rhinitis symptoms in the absence of skin test positivity and specific IgE by performing a nasal provocation test (NPT). METHODS: Our study followed a case-controlled, prospective design. Twenty-eight patients and 30 healthy children were included in the study in a pollen-free season. The NPTs with a grass mix, Dermatophagoides pteronyssinus (DP) and D. farinae (DF) allergens were performed with an interval of 1 week. The total symptom score and visual analog scale, nasal eosinophilia and pulmonary function tests were evaluated before and after each NPT. The change to nasal flow and resistance was recorded by anterior rhinomanometry. RESULTS: The symptom frequencies before the NPTs were as follows: nasal congestion 100%; itching 82.1%; rhinorrhea 75% and sneezing 71.4%. The NPT was positive in 7 (25%) patients. In the NPT-positive group there was a statistically significant decrease in nasal flow at the concentrations of 10 and 100 IR/ml for DF (p = 0.026, p = 0.031, respectively). In the NPT-positive group total nasal resistance for DP was increased at the concentrations of 0.1 and 10 IR/ml, and for DF at 10 and 100 IR/ml (p = 0.049, p = 0.041, p = 0.022, p = 0.035, respectively). CONCLUSIONS: We emphasize that the diagnosis of LAR should be taken into consideration by pediatricians and pediatric allergy specialists.

Measurements of radioactivity and dose assessments in some building materials in Bitlis, Turkey.

In this study, samples of perlite, pumice and Ahlat stones (Ignimbrite) extracted from mines in Bitlis and samples of other building materials produced in facilities in Bitlis were collected and analyzed. Activity concentrations of (226)Ra, (232)Th and (40)K in samples of building materials were measured using NaI detector (NaI(Tl)) with an efficiency of 24%. The radon measurements of building material samples were determined using CR-39 nuclear track detectors. (226)Ra, (232)Th and (40)K radioactivity concentrations ranged from (29.6±5.9 to 228.2±38.1Bq/kg), (10.8±5.4 to 95.5±26.1Bq/kg) and (249.3±124.7 to 2580.1±266.9Bq/kg), respectively. Radon concentration, radium equivalent activities, absorbed dose rate, excess lifetime cancer risk and the values of hazard indices were calculated for the measured samples to assess the radiation hazards arising from using those materials in the construction of dwellings. Radon concentration ranged between 89.2±12.0Bq/m(3) and 1141.0±225.0Bq/m(3). It was determined that Raeq values of samples conformed to world standards except for perlite and single samples of brick and Ahlat stone. Calculated values of absorbed dose rate ranged from 81.3±20.5 to 420.6±42.8nGy/h. ELCR values ranged from (1.8±0.3)×10(-3) to (9.0±1.0)×10(-3). All samples had ELCR values higher than the world average. The values of Hin and Hex varied from 0.35±0.11 to 1.78±0.18 and from 0.37±0.09 to 1.17±0.13, respectively. The results were compared with standard radioactivity values determined by international organizations and with similar studies. There would be a radiation risk for people living in buildings made of perlite, Ahlat-1 and Brick-3.

Investigation of asthma comorbidity in children with different severities of allergic rhinitis.

BACKGROUND: Allergic rhinitis (AR) and asthma comorbidity is widely seen. However, the effects of AR on asthma are more likely to be studied in the literature. OBJECTIVE: To investigate the prevalence of asthma in children with AR who are followed-up and to evaluate the effect of asthma on the severity of AR. METHODS: A total of 509 children with AR who were followed-up in the pediatric allergy-immunology department between January 2012 and December 2013 were enrolled in the study. Asthma and AR are diagnosed by using the Global Initiative for Asthma and the Allergic Rhinitis and its Impact on Asthma, respectively. The patients were categorized into two groups according to the presence of asthma. The two groups were compared according to sociodemographic characteristics, clinical features, and laboratory findings. Skin-prick test results, serum immunoglobulin E levels, and the percentage of eosinophils of the patients were evaluated. RESULTS: A total of 299 of the patients were boys (58.7%) the mean age was 7.2 ± 3.5 years (range, 1.5-18 years). Patients with moderate-severe persistent rhinitis (40.5% of all patients) were the most common rhinitis subgroup. Mild intermittent rhinitis was diagnosed in 17.7%, mild persistent rhinitis in 11.2%, and moderate-severe intermittent rhinitis in 30.6% of the patients. Two hundred seventy-one children with AR (53.2%) also had concomitant asthma. The patients were categorized into two groups: AR-asthma comorbidity group (group I) and AR-only group (group II). There was no significant difference between these two groups when compared with the sex, age, familial atopy, exposure to smoke, and severity of AR (p > 0.05). The duration of illness, immunoglobulin E levels, number of positive sensitivity, sensitivity to house-dust mites, sensitivity to cockroaches, and polysensitization were significantly higher in the AR-asthma comorbidity group (p < 0.05). CONCLUSION: This study showed that asthma comorbidity had no effect on the severity of AR. However, it was also shown that the majority of children with AR had asthma comorbidity. For these purposes, the presence of asthma should be investigated in children with AR, independent of severity.