1.
Org Lett
; 11(7): 1583-6, 2009 Apr 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19260703
RESUMO
Highly enantioselective synthesis of nitrocyclopropanes was achieved via the organocatalytic conjugate addition of dimethyl bromomalonate to nitroalkenes and the consequent intramolecular cyclopropanation. 6'-Demethyl quinine was found to be the efficient catalyst. Excellent enantioselectivities, diastereoselectivities, and good yields were obtained for a variety of aryl or heteroaryl nitroethylenes.