1.
J Pharm Biomed Anal
; 4(1): 37-44, 1986.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16867628
RESUMO
A spectrophotometric method for the measurement of pH in solutions of lidocaine hydrochloride (Xylocaine) for injection is presented. 4-Nitrophenol is used as an indicator for determinations of pH in the range 6.5-7.0. The method was found to be faster than the conventional potentiometric method, mainly due to the utilization of a computer-controlled photodiode array spectrophotometer for the measurements. A further advantage with the spectrophotometric method is that errors arising from varying liquid junction potentials are avoided.