[General anesthesia, hormones and hemodynamics during the excision of tumors of the posterior cranial fossa]. / Obshchaia anesteziia, gormony i gemodinamika pri udalenii opukholei zadnei cherepnoi iamki.

The levels of tropic and peripheral hormones (ACTH, TSH, STH, T3, T4, hydrocortisone, insulin) have been assessed in 74 patients, aged 16 to 64 years, operated on for posterior cranial fossa tumors. Depending on the basic anesthesia component the patients were divided into 3 groups: patients on halothane anesthesia, patients on anesthesia with azeotropic mixture, patients on neuroleptanalgesia. Three hemodynamic variants in the course of operation and postoperative period have been established: patients with normal blood pressure, heart rate, stroke volume; patients with elevated and high blood pressure; patients with unstable hemodynamics. It has been found that general halothane and azeotropic mixture anesthesia is associated with marked changes in intraoperative endocrine function. Endocrine function is changed on the 3rd and 7th day postoperatively due to surgical brain trauma.

[The use of sodium nitroprusside in the anesthesiological support of cerebral angiography]. / Primenenie nitroprussida natriia pri anesteziologicheskom obespechenii tserebral'noi angiografii.

Complex study of the effect of sodium nitroprusside intra-arterial and intravenous infusion under local and general anesthesia on the cerebral, peripheral, and general hemodynamics during cerebral angiography was carried out in 43 patients with neurosurgical pathology (17 females and 26 males from 17 to 58 years of age). The authors proved the efficacy of intraarterial and, to a lesser measure, of intravenous sodium nitroprusside infusion in relieving spasm of the cerebral arteries developing during cerebral angiography.

[Microcirculation in the brain during controlled arterial hypotension. Experimental study of the effect of nipruton]. / Mikrotsirkuliatsiia v golovnom mozge pri upravliaemoi arterial'noi gipotonii. Eksperimental'noe issledovanie vozdeistviia niprutona.

The effect of nipruton (sodium nitroprusside)-induced controlled arterial hypotension on the intracerebral microcirculatory channel was studied on 4 rabbits with transplanted induced tumors (anaplastic astrocytomas) and 7 intact rabbits under general anesthesia. It was found that nipruton injected in doses necessary for marked reduction of arterial pressure (35-45 mm Hg) for a sufficient duration (30-55 minutes) causes no circulatory disorders in the brain. In animals with tachyphylaxis to nitropruton, in which the amount of the injected agent must be increased to 9-10 mg/kg, controlled arterial hypotension even of lesser depth (60-65 mm Hg) and lesser duration (20-25 minutes) can lead to partial obstruction of the intracerebral microcirculatory channel. i. e. to the no-reflow phenomenon.