1.
AIDS
; 27(8): 1353-6, 2013 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23462216
RESUMO
We examined the relationship between plasma adipokine concentrations and ultrasound measures of vascular health in 100 HIV-infected adults on antiretroviral therapy. Leptin was positively correlated with flow-mediated dilation of the brachial artery and negatively with carotid intima-media thickness. These relationships were independent of traditional risk factors and trunk fat in women but not men. Neither adiponectin nor resistin was associated with either measure of vascular health.
Assuntos
Adipocinas/sangue , Doenças das Artérias Carótidas/diagnóstico por imagem , Infecções por HIV/sangue , Obesidade/sangue , Absorciometria de Fóton , Adulto , Fármacos Anti-HIV/uso terapêutico , Índice de Massa Corporal , Artéria Braquial/diagnóstico por imagem , Artérias Carótidas/diagnóstico por imagem , Ensaio de Imunoadsorção Enzimática , Feminino , Infecções por HIV/tratamento farmacológico , Humanos , Leptina/sangue , Masculino , Pessoa de Meia-Idade , Resistina/sangue , Fatores de Risco , Ultrassonografia
2.
Bioorg Med Chem Lett
; 21(6): 1741-3, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21316228
RESUMO
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.