1.
Bioorg Med Chem Lett
; 17(3): 624-7, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17113290
RESUMO
The continual increase in drug resistance; the lack of new chemotherapeutic agents; the toxicity of existing agents and the increasing morbidity with HIV co-infection mean the search for new antileishmanial agents has never been more urgent. We have identified the benzodiazepines as a structural class for antileishmanial hit optimisation, and demonstrated that their in vitro activity is comparable with the clinically used drug, sodium stibogluconate, and that the compounds are not toxic to macrophages.