[The toxic and immunomodulating properties of the somatic O-antigen polysaccharide of typhoid bacteria]. / Toksicheskie i immunomoduliruiushchie svoistva polisakharida O-somaticheskogo antigena bakterii briushnogo tifa.

In experiments on random bred mice and mice of various strains it was shown that when administered parenterally typhoid bacteria O-somatic antigen polysaccharide possesses the immunomodulatory properties. It stimulates the non-specific resistance of the organism to bacterial infection, produces the polyclonal activation of beta-lymphocytes, possesses the adjuvant properties, activates cells of the mononuclear phagocytic system. At administration in therapeutic doses the drug is not toxic, possesses no carcinogenic, mutagenic and allergenic properties.

[Immunomodulating properties of phospholipids]. / Izuchenie immunomoduliruiushchikh svoistv fosfolipidov.

Immunomodulating properties of glycerophospholipids were studied. Both phosphatidyl ethanolamines and phosphatidyl cholines exhibited similar immunostimulating effects.

[Immunomodulating properties of salmozan and its effect on the functional activity of macrophages]. / Immunomoduliruiushchie svoistva sal'mozana i ego vliianie na funktsional'nuiu aktivnost' makrofaga.

The effect of salmozan on the resistance of mice to Listeria monocytogenes infection, the formation of delayed hypersensitivity (DH) to sheep red blood cells in the animals, as well as changes in some functional activity characteristics of macrophages have been studied. The study has revealed that salmozan enhances anti-infectious resistance, suppresses the dermal manifestations of DH, and decreases the level of 5'-nucleotidase in peritoneal macrophages, stimulating their phagocytic activity. The intensity of the drug action depends on the time of its administration. The most pronounced immunomodulating action and maximal changes in the function of macrophages have been registered simultaneously after the treatment of the animals with salmozan.

[Chemical structure and immunostimulating activity of high molecular weight polysaccharides]. / Khimicheskaia struktura i immunostimuliruiushchaia aktivnost' vysokomolekuliarnykh polisakharidov.

An immunostimulating activity of high molecular polysaccharides, dissimilar in their chemical structure, was studied. Inoculation of mice with bacteria of typhoid fever and Kl. pneumoniae demonstrated that O-polysaccharide from typhoid bacteria--multicomponent, branch-chained, phosphorus-containing polysaccharide--exhibited the highest immunostimulating effect. Mannans and glucans, with linear and branch-chained molecules, involving various types of C-C bonds, had lower stimulating properties, which did not correlate with the level of a molecule branching and the type of C-C bonds. These data were confirmed after evaluation of adjuvant properties of high molecular polysaccharides with sheep erythrocytes and their ability to activate macrophages.

[Structural similarity and functional activity of molecular fragments of staphylococcal enterotoxin B and thymopoietin II]. / Strukturnoe skhodstvo i funktsional'naia aktivnost' fragmentov molekul stafilokokkovogo énterotoksina B i timopoétina II.

Structural similarity between Staphylococcus enterotoxin B and a thymus hormone, thymopoietin, has been revealed concerning thymopentin, one of active centres of thymopoietin. Fragments of enterotoxin B homologous to thymopoietin and their analogues were synthesized their immunological activity studied. Acetyl derivative of the fragment 225-229 of enterotoxin B increased infectional resistance and stimulated delayed type of hypersensitivity reaction.

[Neutral lipids as stimulators of natural unspecific immunity]. / Ispol'zovanie neitral nykh lipidov v kachestve stimuliatorov estestvennogo nespetsificheskogo immuniteta.

Neutral lipids (various monoglycerides and cholesterol derivatives) were used as stimulators of natural unspecific immunity. All the compounds studied exhibited the biological activity. Saturated monoglycerides (chimyl and batyl alcohols) and cholesterol derivatives possessed the highest activity. Unsaturated lipids with double bonds were less active.