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1.
Rev Sci Instrum ; 89(11): 116101, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30501329

RESUMO

Many infrared spectroscopy setups are in principle stable enough to run overnight or longer, but the detector's Dewar vessel must be refilled manually with liquid nitrogen (LN2) every couple of hours. Commercial automatic LN2 refilling systems work reliably only for large Dewars. Here, we present a refilling system which can non-invasively be applied to already installed small Dewars. The system reliably refills LN2 once it has dropped below an adjustable level, with quick refilling (<3 min) for a 0.6 l Dewar. Our design protects the setup and the detector from overflowing or running without LN2.

2.
Phys Rev Lett ; 87(25): 256802, 2001 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-11736594

RESUMO

We define two laterally gated small quantum dots with less than 15 electrons in an Aharonov-Bohm geometry in which the coupling between the two dots can be changed. We measure Aharonov-Bohm oscillations for weakly coupled quantum dots. In an intermediate coupling regime we study molecular states of the double dot and extract the magnetic field dependence of the coherently coupled states.

3.
Trop Med Int Health ; 6(10): 756-60, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11679122

RESUMO

The increasing resistance of Plasmodium falciparum in the treatment of uncomplicated malaria with pyrimethamine/sulphadoxine has been associated in several studies with the occurrence of point mutations in the genes of dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS). In this study, the prevalence of these mutations was examined in samples from south-east Mauritania, where atypically strong rainfalls in 1998 and 1999 led to a severe outbreak of falciparum malaria. We analysed 386 samples by polymerase chain reaction (PCR) for infection with P. falciparum, of which 162 (41.97%) were positive. These isolates were examined for point mutations in the genes of DHFR (codons 16, 51, 59, 108 and 164) and DHPS (codons 436, 437, 540, 581 and 613) by nested PCR and subsequent mutation-specific restriction enzyme digest. We found a low overall prevalence of DHFR gene mutations (up to 18.6% of isolates), but a high overall prevalence of DHPS gene mutations (up to 49.1% of isolates). Thus, emerging resistance to antifolate drugs may be expected to develop soon in the investigated area. This study demonstrates the utility of simple, relatively rapid and inexpensive molecular methods and their application in surveillance programmes. Testing for prevalence of point mutations conferring antifolate resistance might help to identify the developing of drug resistance at a very early stage.


Assuntos
Di-Hidropteroato Sintase/genética , Malária Falciparum/epidemiologia , Plasmodium falciparum/genética , Tetra-Hidrofolato Desidrogenase/genética , Adolescente , Adulto , Animais , Antimaláricos/farmacologia , Antimaláricos/uso terapêutico , Criança , Pré-Escolar , Cloroquina/farmacologia , Cloroquina/uso terapêutico , Surtos de Doenças , Combinação de Medicamentos , Resistência a Medicamentos , Feminino , Humanos , Lactente , Malária Falciparum/tratamento farmacológico , Masculino , Mauritânia/epidemiologia , Pessoa de Meia-Idade , Plasmodium falciparum/efeitos dos fármacos , Plasmodium falciparum/enzimologia , Reação em Cadeia da Polimerase , Polimorfismo de Fragmento de Restrição , Prevalência , Pirimetamina/farmacologia , Pirimetamina/uso terapêutico , Sulfadoxina/farmacologia , Sulfadoxina/uso terapêutico
4.
Phys Rev Lett ; 86(9): 1837-40, 2001 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-11290261

RESUMO

Under an external magnetic field, new branches of spin- and charge-density waves have been studied in a quasi-two-dimensional electron system whose ground state has more than one Landau level occupied by electrons. These collective excitations can be treated as manifestations of the multicomponent nature of the electron system in magnetic field, whereas the occupied Landau levels should be associated with degrees of freedom.

5.
Nature ; 410(6825): 168, 2001 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-11242068
6.
Phys Rev Lett ; 84(16): 3702-5, 2000 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-11019181

RESUMO

An enhancement of vortex-motion damping in thin Pb/In superconducting films is obtained through coupling to an adjacent two-dimensional electron gas formed in a modulation-doped GaAs/AlGaAs heterostructure. This effect is observed by monitoring the power dissipation in the superconductor in the vortex state while increasing the density of the electron gas using a gate voltage. Quantitative agreement is found with calculations based on a viscous damping model which considers generation of eddy currents in the electron gas by moving flux lines. In the regime of filamentary vortex flow, eddy-current damping leads to a striking dissipation breakdown due to the stopping of entire vortex channels.

7.
Phys Rev Lett ; 85(17): 3688-91, 2000 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-11030982

RESUMO

We demonstrate that the temperature dependence of the electron spin polarization for the fractional states nu = 1/3 and nu = 2/3 displays activated behavior. This study enables the first measurement of the fractional quantum Hall spin-flip gaps. They are found to be systematically larger in comparison with the gaps simultaneously measured in transport. For nu = 1/3 and nu = 1/2, these spin-flip gaps allow the determination of the composite fermion interaction energy. This energy is investigated as a function of the finite width of the 2D channel.

8.
Phys Rev Lett ; 84(25): 5824-7, 2000 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-10991064

RESUMO

Zero-bias anomalies in the conductance through quantum dots have recently been identified as Kondo resonances and explained in terms of the Anderson impurity model. The effect requires a degeneracy and it has been proposed that this should occur for odd electron numbers on the dot. In this paper we present data, obtained on a split-gate quantum dot with a small number of electrons, which are in disagreement with this expectation. The mapping of the Anderson model on the quantum dot is discussed in terms of an interacting N electron system demonstrating why this expectation can fail.

9.
Nature ; 408(6815): 946-9, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-11140675

RESUMO

Ion conduction is of prime importance for solid-state reactions in ionic systems, and for devices such as high-temperature batteries and fuel cells, chemical filters and sensors. Ionic conductivity in solid electrolytes can be improved by dissolving appropriate impurities into the structure or by introducing interfaces that cause the redistribution of ions in the space-charge regions. Heterojunctions in two-phase systems should be particularly efficient at improving ionic conduction, and a qualitatively different conductivity behaviour is expected when interface spacing is comparable to or smaller than the width of the space-charge regions in comparatively large crystals. Here we report the preparation, by molecular-beam epitaxy, of defined heterolayered films composed of CaF2 and BaF2 that exhibit ionic conductivity (parallel to the interfaces) increasing proportionally with interface density--for interfacial spacing greater than 50 nanometres. The results are in excellent agreement with semi-infinite space-charge calculations, assuming a redistribution of fluoride ions at the interfaces. If the spacing is reduced further, the boundary zones overlap and the predicted mesoscopic size effect is observed. At this point, the single layers lose their individuality and an artificial ionically conducting material with anomalous transport properties is generated. Our results should lead to fundamental insight into ionic contact processes and to tailored ionic conductors of potential relevance for medium-temperature applications.

10.
Opt Lett ; 25(8): 572-4, 2000 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-18064115

RESUMO

In 1994 Butov et al. [Phys. Rev. Lett. 73, 304 (1994)] reported large, extremely low-frequency fluctuations in the luminescence intensity from indirect excitons in a coupled quantum well. We have reproduced these fluctuations in a similar structure. Our observations indicate, however, that the fluctuations are spectral fluctuations rather than intensity fluctuations. We have eliminated several possible causes for the fluctuations and propose a possible cause.

11.
J Microsc ; 194(1): 12-20, 1999 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10320536

RESUMO

Convergent beam electron diffraction is used for the quantitative determination of layer thickness, composition and strain in pseudomorphic Si/SiGe two- and three-layer systems grown by molecular beam epitaxy. By using plan-view specimens, we are able to avoid the influence of surface relaxation which generally complicates the determination of strains in cross-sectional specimens. For quantitative strain determination, rocking curves of Bragg lines in energy-filtered convergent beam electron diffraction patterns are analysed. The experimentally obtained rocking curves are compared with kinematical calculations by a computerized fit procedure. The resulting layer parameters are then further refined by a dynamical simulation. Results for the strains obtained with this technique are in good agreement with theoretical values. With this method layer thickness is measured down to monolayer precision. The accuracy of the strain analysis depends on the sequence and thickness of the layers.

12.
18.
Phys Rev B Condens Matter ; 54(7): 4913-4918, 1996 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-9986453
19.
Phys Rev Lett ; 77(1): 147-150, 1996 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-10061793
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