Ultra-high-resolution CT vs. invasive angiography for detecting hemodynamically significant coronary artery disease: Rationale and methods of the CORE-PRECISION multicenter study.

BACKGROUND: Direct coronary arterial evaluation via computed tomography (CT) angiography is the most accurate noninvasive test for the diagnosis of coronary artery disease (CAD). However, diagnostic accuracy is limited in the setting of severe coronary calcification or stents. Ultra-high-resolution CT (UHR-CT) may overcome this limitation, but no rigorous study has tested this hypothesis. METHODS: The CORE-PRECISION is an international, multicenter, prospective diagnostic accuracy study testing the non-inferiority of UHR-CT compared to invasive coronary angiography (ICA) for identifying patients with hemodynamically significant CAD. The study will enroll 150 patients with history of CAD, defined as prior documentation of lumen obstruction, stenting, or a calcium score ≥400, who will undergo UHR-CT before clinically prompted ICA. Assessment of hemodynamically significant CAD by UHR-CT and ICA will follow clinical standards. The reference standard will be the quantitative flow ratio (QFR) with <0.8 defined as abnormal. All data will be analyzed in independent core laboratories. RESULTS: The primary outcome will be the comparative diagnostic accuracy of UHR-CT vs. ICA for detecting hemodynamically significant CAD on a patient level. Secondary analyses will focus on vessel level diagnostic accuracy, quantitative stenosis analysis, automated contour detection, in-depth plaque analysis, and others. CONCLUSION: CORE-PRECISION aims to investigate if UHR-CT is non-inferior to ICA for detecting hemodynamically significant CAD in high-risk patients, including those with severe coronary calcification or stents. We anticipate this study to provide valuable insights into the utility of UHR-CT in this challenging population and for its potential to establish a new standard for CAD assessment.

Day of the Week Variation in Emergency Department Arrivals, Chest Pain, and Acute Myocardial Infarction Throughout 2016-2019.

Overcrowding in the Emergency department (ED) necessitates a major challenge in delivering high-quality care in acute settings. This study presents a novel approach to modeling the relationship between the day of the week, ED arrivals, chest pain (CP), and acute myocardial infarction (AMI) using regression analysis. We analyzed data from 2016 to 2019 across three platforms: a nationwide representative sample (NHAMCS), a federated data network (TriNetX), and a regional medical center. For the stated three outcomes, the number of patients in that category on each day of the week was calculated; these were then calculated separately for each year, as well as across all four years. In line with prior studies, this study demonstrates the highest percentage of ED arrival on Mondays and the lowest on the weekends. Similarly, chest pain was more prevalent on Mondays, with similar patterns for TriNetX and the regional medical center. Analyzing NHAMCS data demonstrated Wednesdays as the busiest day for AMI-related ED arrivals, although this observation was not statistically significant. This knowledge will better aid us in resource allocation and system awareness, paving a path toward better patient care, improving disease management, and reducing healthcare costs.