RESUMO
The percentage of sperm DNA damage in samples from sperm bank donors was not significantly different (P=.17), whereas the percentage of motile cells was lower (P=.009) after long-term (9-13 years) compared with short-term (1-5 years) storage. Density gradient isolation reduced the difference in sperm motility between the two groups.
Assuntos
Dano ao DNA/fisiologia , Preservação do Sêmen/métodos , Manejo de Espécimes/métodos , Bancos de Esperma/métodos , Motilidade dos Espermatozoides/fisiologia , Espermatozoides/citologia , Espermatozoides/fisiologia , Adulto , Humanos , MasculinoRESUMO
A similarity was found between the percentage of thawed, DNA-damaged spermatozoa in cancer patients and that in candidates to become sperm bank donors who had low sperm cryofreezability. Both groups were significantly different from the sperm bank donor group. It is suggested that the higher rate of DNA fragmentation in sperm from cancer patients compared with sperm bank donors is apparently a result of selecting donors by the level of sperm cryofreezability (i.e., high), rather than a direct effect of an existing malignancy.