RESUMO
A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later developed progressive encephalitis. Cerebrospinal fluid was negative for pathogens including HCoV-OC43, but a brain biopsy was HCoV-OC43-positive by metagenomic next-generation sequencing.
Assuntos
Infecções por Coronavirus/virologia , Coronavirus Humano OC43/fisiologia , Encefalite/virologia , Encéfalo/patologia , Encéfalo/virologia , Infecções por Coronavirus/imunologia , Infecções por Coronavirus/mortalidade , Infecções por Coronavirus/patologia , Coronavirus Humano OC43/isolamento & purificação , Encefalite/imunologia , Encefalite/mortalidade , Encefalite/patologia , Evolução Fatal , Humanos , Hospedeiro Imunocomprometido , LactenteRESUMO
The disease spectrum associated with human bocavirus-1 infection remains to be fully defined. We report a case of bocavirus-1-associated bronchiolitis, leading to severe respiratory failure and extracorporeal membrane oxygenation in a 4-year-old child, and suggest blood testing for human bocavirus-1 in children with severe respiratory tract infection.