RESUMO
OBJECTIVE: To assess the level of agreement on various prevention and management strategies for irritation caused by topical retinoids in facial and trunk acne in an attempt to alleviate it and minimize treatment discontinuations as much as possible. METHOD: After reviewing the scientific medical literatura currently available, 4 different areas of uncertainty in the management of irritation caused by topical retinoids in acne were identified. A questionnaire with 34 recommendations was created and evaluated by a group of 133 dermatologists (Delphi methodology). RESULTS: In 82.3% of the recommendations (28 out of 34), some level of agreement was reached (≥85% agreement in 22 recommendations and≥70% agreement in 6). The results with the highest level of agreement focused on specific patient education strategies (explaining that irritation is an expected reaction at the beginning of treatment and tends to decrease over time), gradual and/or spaced application of topical retinoids (at night time to prevent and/or reduce skin irritation), and the importance of using adjuvant products, specific for acne-prone skin, hydration, photoprotection, and skin cleansing. These recommendations reflect a comprehensive approach to managing irritation associated with topical retinoids and promoting long-term adherence. CONCLUSIONS: Skin irritation caused by topical retinoids in facial and trunk acne is an expected, mild, and controllable reaction if proper prevention and management guidelines are followed, meaning that it should not be a reason for treatment discontinuation.
Assuntos
Acne Vulgar , Retinoides , Tronco , Acne Vulgar/tratamento farmacológico , Humanos , Retinoides/efeitos adversos , Retinoides/uso terapêutico , Retinoides/administração & dosagem , Dermatoses Faciais/prevenção & controle , Face , Fármacos Dermatológicos/uso terapêutico , Fármacos Dermatológicos/efeitos adversos , Educação de Pacientes como Assunto , Guias de Prática Clínica como AssuntoAssuntos
Anticoagulantes/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Fibrinolíticos/uso terapêutico , Heparina de Baixo Peso Molecular/efeitos adversos , Polissacarídeos/uso terapêutico , Idoso de 80 Anos ou mais , Feminino , Fondaparinux , Hirudinas , Humanos , Proteínas Recombinantes/uso terapêuticoAssuntos
Erupções Acneiformes/induzido quimicamente , Antineoplásicos/efeitos adversos , Inibidores de Proteínas Quinases/efeitos adversos , Quinazolinas/efeitos adversos , Antineoplásicos/farmacocinética , Antineoplásicos/uso terapêutico , Braço , Carcinoma de Células Escamosas/tratamento farmacológico , Carcinoma de Células Escamosas/radioterapia , Carcinoma de Células Escamosas/cirurgia , Terapia Combinada , Receptores ErbB/antagonistas & inibidores , Cloridrato de Erlotinib , Dermatoses Faciais/induzido quimicamente , Humanos , Neoplasias Laríngeas/tratamento farmacológico , Neoplasias Laríngeas/radioterapia , Neoplasias Laríngeas/cirurgia , Laringectomia , Masculino , Pessoa de Meia-Idade , Esvaziamento Cervical , Proteínas de Neoplasias/antagonistas & inibidores , Especificidade de Órgãos , Inibidores de Proteínas Quinases/farmacocinética , Inibidores de Proteínas Quinases/uso terapêutico , Quinazolinas/farmacocinética , Quinazolinas/uso terapêutico , Radioterapia Adjuvante , Pele/efeitos da radiação , TóraxRESUMO
Cutaneous calcinosis can be classified into four types: dystrophic, metastatic, idiopathic and iatrogenic. Dystrophic calcification constitutes the most frequent variant and is associated with a large number of illnesses, among which are included some collagen diseases such as CREST syndrome, scleroderma, dermatomyositis and lupus erythematosus. We present a case of dystrophic calcinosis cutis, affecting the fingertip of a woman with a 10-year history of primary Sjögren's syndrome (SS). She has been receiving diltiazem as a treatment for the last 15 months, resulting in the partial resolution of the lesions. We emphasize the fact that the presence of calcinosis cutis has not been described previously in patients with SS, and that diltiazem has partially improved our patient's cutaneous lesions.