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Br J Exp Pathol ; 61(4): 380-9, 1980 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7426389

RESUMO

Samorin (isometamedium chloride) was effective against T. evansi in mice given in single i.p. doses of 1 to 10 mg/kg. The administration of 40 mg/kg of samorin or above caused rapid death of mice and there were severe haemorrhages, degeneration and congestion in the liver, heart and kidney. The lesions in the liver and kidney were accompanied with reduced activities of ATP-ase, 5-nucleotidase, succinic tetrazolium reductase and glucose-6-phosphatase.


Assuntos
Tripanossomicidas/uso terapêutico , Tripanossomíase/tratamento farmacológico , Animais , Feminino , Rim/enzimologia , Rim/patologia , Fígado/enzimologia , Fígado/patologia , Camundongos , Miocárdio/patologia , Fagocitose , Tripanossomíase/enzimologia , Tripanossomíase/patologia
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