Challenges in the management of severe cutaneous mucormycosis: A case of rapid progression in uncontrolled diabetes mellitus with polymicrobial implications.

Mucormycosis, a rare but life-threatening fungal infection, poses significant challenges in clinical management, particularly in patients with uncontrolled diabetes mellitus. This case report presents the clinical journey of a 44-year-old woman who developed a rapidly progressing Mucorales infection following a domestic knife injury. Her condition, complicated by diabetic ketoacidosis and co-infection with Candida albicans, led to severe hand phlegm and sepsis. Despite aggressive intervention, the infection continued to advance, ultimately resulting in the patient's demise.

Rhino-Orbito-Cerebral Mucormycosis: A Challenging Case.

Mucormycosis is a rare opportunistic fungal infection caused by Mucorales and associated with high mortality rates. Rhino-orbito-cerebral localization usually occurs in individuals with uncontrolled diabetes mellitus. We report the case of a 41-year-old male, with previously undiagnosed diabetes, who presented with unilateral facial extensive black eschar and signs of diabetic ketoacidosis. Cerebral magnetic resonance imaging showed left pansinusitis, left craniofacial edematous infiltrate, and left proptosis. A left internal temporal abscess was identified at an early pre-suppurative stage. Magnetic resonance angiography revealed total occlusion of the left intracranial internal carotid artery. A histopathological study of nasal mucosa biopsy suggested mucormycosis. According to the clinical presentation and the radiological and histopathological findings, rhino-orbito-cerebral mucormycosis was presumed. Culture of nasal, ocular, and skin lesion specimens grew Rhizomucor sp. and confirmed the diagnosis. The patient was treated with systemic liposomal amphotericin B. He died of multiple organ failure before surgical debridement was possible as he was in critical condition requiring stabilization before surgical treatment.

Saprochaete Capitata Peritonitis in a Non-neutropenic Patient Without Underlying Malignancies: A Case Report.

Saprochaete capitata (S. capitata) is an opportunistic arthroconidial yeast-like fungus causing invasive infections in immunocompromised patients, mainly those with hematological malignancies and severe neutropenia. However, infections due to S. capitata are extremely rare in immunocompetent and non-neutropenic patients. Saprochaete spp. are microscopically characterized by arthroconidia with hyaline-septated hyphae. S. capitata is known to be intrinsically resistant to echinocandins and highly resistant to fluconazole. It is suggested to use amphotericin B or voriconazole (in monotherapy or in combination) as the gold standard treatment for S. capitatasystemic infections. We report a rare case of S. capitata peritonitis with fatal outcome in a non-neutropenic patient without underlying malignancies. This case report highlights the value of direct microscopic examination and stained smears in a prompt preliminary diagnosis of S. capitata invasive fungal infections. We also aim to emphasize the importance of early initiation of appropriate antifungal treatment in patients with S. capitata systemic infections, thus improving their therapeutic outcome.

Disseminated Cryptococcosis Revealing an HIV Infection: A Case Report.

Cryptococcosis is a common fungal infection regarded as a disease of immunocompromised patients with high mortality. Cryptococcosis is usually observed in the central nervous system and lungs. However, other organs may be involved such as skin, soft tissue, and bones. Disseminated cryptococcosis is defined as fungemia or the involvement of two distinct sites. Here, we report the case of a 31-year-old female patient with disseminated cryptococcosis with neuro-meningeal and pulmonary involvement revealing a human immunodeficiency virus (HIV) infection. Chest computed tomography scan showed a right apical excavated lesion, pulmonary nodules, and mediastinal lymphadenopathy. Concerning biological tests, hemoculture, sputum, and cerebrospinal fluid (CSF) culture were positive for Cryptococcus neoformans. The latex agglutination test for cryptococcal polysaccharide antigen was positive in CSF and serum and HIV infection was confirmed by serological testing. The patient did not respond to initial antifungal therapy with amphotericin B and flucytosine. Despite the adaptation of antifungal treatment, the patient died of respiratory distress.

Cardiac Echinococcosis With Hepatic Involvement in a Child: A Case Report.

Hydatidosis is endemic in Morocco. Cardiac localization of hydatid disease is a rare entity. Involvement of the interventricular septum is even rarer. We report the case of a 6-year-old girl with combined hepatocardiac hydatid disease. She was admitted with complaints of dyspnea, asthenia and vomiting. Ultrasound imaging and CT scan showed cystic lesions in the interventricular septum and in the liver. Serologic test results were positive. According to the biological and radiological findings, the diagnosis of echinococcosis with cardiac and hepatic involvement was suggested. Complete excision of the cardiac cyst was performed followed by anthelminthic treatment with albendazole as a supportive therapy. The confirmative diagnosis of hydatid disease was made by microscopic examination of the removed material. Our patient was referred to the department of general surgery to treat the liver lesions in the future. The postoperative period was unremarkable.

A case of Saprochaete capitata pulmonary infection in a neutropenic HIV-infected patient.

Introduction: Saprochaete capitata is an emerging opportunistic fungus that is responsible for an uncommon mycosis known as geotrichosis, mainly reported in patients with haematological malignancies. It is a life-threatening condition associated with a high mortality rate of over 52 %. S. capitata may affect any organ, with a predilection for the lungs. Case presentation: Here we report a case of pulmonary geotrichosis in a neutropenic HIV-infected patient with a prior history of treated tuberculosis. The main risk factor for pulmonary geotrichosis is profound and prolonged neutropenia. To our knowledge, this is the first reported case of S. capitata infection occurring on top of probable active miliary tuberculosis. Conclusion: The clinical and radiological features are non-specific and similar to those of other pulmonary fungal diseases, hence the importance of mycological examination to confirm the diagnosis. Through this report, we urge clinicians to vigilantly consider S. capitata as an aetiological agent in the differential diagnosis of fungal infections in HIV-infected individuals and to routinely screen for associated infections.

Multiple Cerebral Hydatid Cysts: A Case Report.

Hydatidosis is an endemic disease in Morocco. Intracranial localization is relatively unaccustomed and usually occurs in a solitary form. It is even rarer to find multiple intracranial hydatid cysts. Patients are frequently children and young adults. We report the case of a 22-year-old woman with recurrent multiple cerebral hydatid disease occurring seven years after resection of a primary cyst. She was admitted due to high intracranial pressure and generalized seizures. Brain CT scan showed several intracranial multivesicular cysts in the left parieto-occipital region with localized calcifications. According to the radiological results and patient story, the diagnosis of cerebral hydatidosis was presumed. The patient underwent complete excision of the cysts followed by medical therapy. The parasitological and histological examination of the surgical specimen confirmed the diagnosis. The transient neurological deficit was the only postoperative complication improved, thanks to reeducation in the early phase. The patient was discharged in good condition with no other complications at the follow-up.