RESUMO
Because of the socio-economic condition of African countries, the traditional types of vaccines should be encouraged. LTV in a preliminary study, proved to be of value in reducing morbidity and mortality in Schistosoma mansoni infection. In the present study and because of the vaccine contains liver tissue homogonate, the present authors analyed the DNA content of the hepatocytes of the vaccinated and control groups of animals to know any effects of the vaccine on the hepatocytes ploidy. The DNA content of vaccinated animals was higher. The results were discussed. It was concluded that for testing S. mansoni vaccine, DNA analysis of heptocytes for detecting proliferative S-phase is an important as a positive immune reaction.
Assuntos
DNA/análise , Hepatócitos/química , Fígado/imunologia , Esquistossomose mansoni/prevenção & controle , Vacinas/imunologia , Animais , Hepatócitos/citologia , Fígado/parasitologia , Fígado/patologia , Masculino , Camundongos , Ploidias , Fase S , Schistosoma mansoni/imunologia , Esquistossomose mansoni/imunologia , VacinaçãoRESUMO
Liver tissue of Schistosoma mansoni-infected hamsters has been tried to immunize white mice against Schistosoma mansoni infection. A saline suspension of liver tissue of infected hamsters was prepared and given subcutaneously in the ventral aspect of the abdominal wall to the right of the umbilicus. The present study proved that the used vaccine has a protective role in reducing the morbidity and mortality of the disease.