Assuntos
Acetábulo/fisiopatologia , Artroscopia/métodos , Osteocondrite Dissecante/diagnóstico , Osteocondrite Dissecante/cirurgia , Adulto , Feminino , Seguimentos , Articulação do Quadril/fisiopatologia , Humanos , Imageamento por Ressonância Magnética , Medição da Dor , Recuperação de Função Fisiológica , Medição de Risco , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
The resistance to erythropoietin, which is used to treat normochromic, normocytic anemia in chronic renal failure, can develop in patients with conditions such as iron deficiency, aluminum toxicity, hyperparathyroidism, chronic inflammatory diseases, and primary hematological disorders. We found amyloidosis in the bone marrow of a woman without any other etiology for erythropoietin resistance who was undergoing chronic hemodialysis. Her anemia did not improve, despite 6 months of erythropoietin therapy. Bone marrow amyloidosis was found to be the reason for erythropoietin-resistant anemia in our patient with chronic renal failure and renal anemia. We present the case of bone marrow amyloidosis because it is a very rare cause of erythropoietin resistance.
Assuntos
Amiloidose/complicações , Amiloidose/diagnóstico , Anemia/tratamento farmacológico , Anemia/etiologia , Doenças da Medula Óssea/complicações , Doenças da Medula Óssea/diagnóstico , Resistência a Medicamentos , Eritropoetina/uso terapêutico , Falência Renal Crônica/complicações , Falência Renal Crônica/terapia , Diálise Renal , Adulto , Amiloidose/terapia , Anemia/diagnóstico , Doenças da Medula Óssea/terapia , Feminino , HumanosRESUMO
Experimental acute sinusitis was induced in 21 New Zealand hybrid rabbits by occluding the ostium and inoculating them with Streptococcus pneumonia. While a group of rabbits with sinusitis was left untreated, two other groups were administered parenteral sodium nitroprussid (SNP) and oral levofloxacin for ten days. While staphylococci species, non-hemolytic streptococcus and contaminated flora were isolated from the sinuses of controls, Streptococcus pneumonia was re-isolated in two of six untreated rabbits, in one of six SNP administered rabbits and none of the levofloxacin treated rabbits. Serum and maxillary sinus mucosal nitric oxide (NO) levels were correlated. While the mean maxillary sinus NO level of controls was significantly higher than that of untreated rabbits, the mean maxillary sinus and serum NO levels were significantly higher in SNP administered rabbits than in the others. Although goblet cell hyperplasia and squamous cell metaplasia were detected in some slides, edema and neutrophil infiltration were the prominent findings. The most severe inflammatory changes were found in the untreated sinusitis group on the third and fifth days. The earliest improvement was observed in the levofloxacin treated rabbits. It was concluded that NO level is decreased during acute sinusitis and that SNP administration hastens the bacteriological and histological recovery.
Assuntos
Seio Maxilar/metabolismo , Sinusite Maxilar/metabolismo , Óxido Nítrico/metabolismo , Mucosa Respiratória/metabolismo , Doença Aguda , Animais , Infecções Bacterianas , Seio Maxilar/patologia , Sinusite Maxilar/sangue , Sinusite Maxilar/microbiologia , Sinusite Maxilar/patologia , Óxido Nítrico/sangue , Coelhos , Mucosa Respiratória/patologiaRESUMO
Tuberous sclerosis (TS) is an autosomal dominant disorder. It is characterized by hamartomatous lesions in various organs such as the brain, skin, kidneys and heart. Subependymal and parenchymal nodules occur in the cerebrum. Although giant cell astrocytoma may develop from these subependymal nodules, tumor formation is very rare in the cortical nodules. We present the clinical, computed tomography and magnetic resonance imaging findings of a fibrillary astrocytoma originating from a cortical tuber in a 4-year-old female with TS.