RESUMO
Clinico-anatomical analysis, chemico-toxicological and histological examination of material from 54 deceased from intoxication with azaleptin both in urgent toxicology department and pre-admission stage, were performed. Morphology of intoxication with azaleptin was studied, structural base of genopathy at these intoxications was developed.
Assuntos
Antipsicóticos/intoxicação , Doença Hepática Induzida por Substâncias e Drogas/patologia , Clozapina/intoxicação , Medicina Legal , Fígado/patologia , Doença Aguda , Adulto , Idoso , Antipsicóticos/sangue , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Doença Hepática Induzida por Substâncias e Drogas/mortalidade , Clozapina/sangue , Feminino , Humanos , Peroxidação de Lipídeos , Fígado/metabolismo , Masculino , Pessoa de Meia-Idade , Necrose , Pancreatopatias/induzido quimicamente , Pancreatopatias/patologia , Intoxicação/etiologia , Intoxicação/mortalidade , Intoxicação/patologiaRESUMO
Clinical and laboratory parameters were comparatively assessed in persons from two age groups (15-59 and 60-89 years) on their admission to hospital and in the course of equal treatment. The elderly and senile patients showed a higher incidence of inflammatory complications and death in the toxicogenic and somatogenic phases of acute intoxication with delayed recovery of laboratory parameters.
Assuntos
Envelhecimento , Psicotrópicos/intoxicação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Intoxicação/diagnóstico , Intoxicação/etiologia , Intoxicação/terapia , Índice de Gravidade de Doença , Resultado do Tratamento , Adulto JovemRESUMO
In cases of acute azaleptin poisoning (AAP), the parameters of endogenous intoxication (EI) were studied in patients both with complicated pneumonias and without them. The integral EI index endogenous intoxication coefficient (Cei) was developed, which simultaneously reflects the coupling capacity of albumin of hydrophilic toxins and lipid peroxidation products: Cei (MMWP x MDA/EAC) x 1000, where MMWP is medium molecular-weight peptides; MDA is malonic dialdehyde; EAC is the effective albumin concentration. The use of Cei significantly enhances the efficiency of diagnosis of early-stage EI and provides a more objective assessment of therapy in AAP patients. EI is more severe when poisoning is concurrent with complicated pneumonias. Cei is of informative value in the assessment of a risk for pneumonias in AAP, which may be used in various emergencies accompanied by EI.