Is overweight a risk factor for wheezing in pre-school children? A study in 14 Brazilian communities.

OBJECTIVE: To evaluate the association between overweight and wheezing in pre-school children in 14 small Brazilian communities. METHODS: Cross-sectional epidemiological study, conducted between 2001 and 2002. A sample of 3453 children under 5 years of age was taken from nine communities in the state of Bahia and five in the state of São Paulo. Data on housing, family and children were obtained by applying structured questionnaires in loco. Weight and height for each child were also measured. The association between wheezing and overweight was assessed by unconditional logistic multivariate regression models. RESULTS: Overweight children had a greater frequency of wheezing and an odds ratio of 2.57 (95% confidence interval 1.51-4.37) was estimated after controlling for several potential confounding variables. The magnitude of the risk was not affected by several different model specifications. CONCLUSION: Excess weight is associated with increased risk for wheezing in this population of children below 5 years of age.

Assessing morbidity in the paediatric community.

INTRODUCTION: Morbidity information is easily available from medical records but its scope is limited to the population attended by the health services. Information on the prevalence of diseases requires community surveys, which are not always feasible. These two sources of information represent two alternative assessments of disease occurrence, namely demand morbidity and perceived morbidity. The present study was conceived so as to elicit a potential relationship between them so that the former could be used in the absence of the latter. METHODS: A community of 13,365 families on the outskirts of S. Paulo, Brazil, was studied during the period from 15/Nov/1994 to 15/Jan/1995. Data regarding children less than 5 years old were collected from a household survey and from the 2 basic health units in the area. Prevalence of diseases was ascertained from perceived morbidity and compared to estimates computed from demand morbidity. RESULTS: Data analysis distinguished 2 age groups, infants less than 1 year old and children 1 to less than 5. The most important groups of diseases were respiratory diseases, diarrhoea, skin problems and infectious & parasitical diseases. Basic health units presented a better coverage for infants. Though disease frequencies were not different within or outside these units, a better coverage was found for diarrhoea and infectious & parasitical diseases in the infant group, and for diarrhoea in the older age group. Equivalence between the two types of morbidity was found to be limited to the infant group and concerned only the best covered diseases. The odds of a disease being seen at the health service should be of at least 4:10 to ensure this equivalence. CONCLUSION: It was concluded that, provided that health service coverage is good, demand morbidity can be taken as a reliable estimate of community morbidity.

Risk of linear growth retardation during the first two years of life: a new approach.

OBJECTIVE: Estimate the risk of linear growth retardation during the first two years of life as a result of household social vulnerability. SETTING: Families who participated in the National Supplementary Feeding Program in the Health Units of the metropolitan area of the city of São Paulo, Brazil. SUBJECTS: Four hundred and thirty-one index-babies, weighing more than 2500 grams and who had at least one young sibling under the age of five who participated in the Program for a minimum of two years. DESIGN: The index-babies were divided into two cohorts: 74.9% coming from 'non-stunted families' (those with normal height siblings) and 25.1% from 'stunted families' (those with stunted siblings). The study design allowed the observation of growth patterns over a period of time and over a childhood growth range. It also allowed the estimation of the stunting and the recovery probabilities at each moment, not only within a given age range. The transition probabilities between 'stunted' and 'non-stunted' index-babies were estimated. The relative risk ratio (RR) was also calculated. RESULTS: The prevalence of stunting in the index-babies at 12 and 24 months of age was significantly greater in 'stunted families' (P < 0.001). Probabilities of becoming stunted began to differ from the fourth month on (confidence intervals non-superposed), and were higher for index-babies from 'stunted families'. The recovery probability of a stunted child was smaller in the 'stunted families' cohort after the 12th month of age. From the third month on, the (RR) was always above 1.5. CONCLUSION: The family context exposes children to failure in growth in the first two years of life when there are already stunted children in the household.

The importance of clinical symptoms and signs in the diagnosis of community-acquired pneumonia.

A sample of 153 children was drawn from a teaching hospital in Säo Paulo, Brazil. It comprised 51 pneumonia cases and equal number of non-respiratory and healthy controls matched by age and sex. Age ranged from 1 month to 7 years. They were all submitted to a standard protocol to investigate clinical symptoms and signs, and diagnosis of pneumonia was supported by X-ray images. Univariate data analysis contrasting pneumonia and non-pneumonia subjects suggested that the best pneumonia indicators would be chest auscultation, history of breathlessness, history of cough, chest in-drawing and fast respiratory rate, in descending order. A multivariate approach including also data from X-ray investigation was then tried with the application of multiple discriminant analysis to study the separation of pneumonia cases, non-respiratory patients and healthy children. It revealed that when many items of information are considered the performance of individual symptoms and signs change. The best predictors of pneumonia were then identified as chest in-drawing, chest auscultation, X-ray, history of breathlessness and toxaemia. Clinical symptoms taken all together contribute more than signs and equal X-ray in importance. Accordingly, it is concluded that any attention to X-ray should be secondary to clinical investigation, and it is suggested that the WHO's guidelines could profit with the inclusion of at least one clinical symptom, namely history of breathlessness which was found more useful than the WHO recommended breath count.

[Defining priorities for the management of health science and technology]. / Definindo prioridades de gestão de ciência e tecnologia em saúde.

INTRODUCTION: An urgent need for the management of science and technology production in the health field has been recognised in Brazil since 1994, when the Federal Government called a National Conference on the subject. The present study presents a methodology for the identification of items of priority in planning such management. MATERIAL AND METHOD: A survey was conducted in the research institutes belonging to the S. Paulo State Health Department among a sample of research professionals with a view to collecting data on two different scenarios: present and expected situation. Eighteen concepts, assembled in four different groups, were assessed is terms of an average percentage approval or disapproval, for each scenario. Consistency for the measurement of each of these groups was examined by the use of Cronbach's alpha coefficient and inconsistent concepts were disregarded in the analysis. The average percentage of approval/disapproval was further calculated as scenario co-ordinates for each concept and institute entering the study so that priority maps for concepts and institutes could be constructed. RESULTS: Results suggest that the present situation meets with disapproval, though not strongly so, while a high degree of expectation is expressed with significant emphasis as regards research infrastructure management. The main priorities are given as: acknowledgement of performance, support for publication, resource allocation by research project and methodological advice for research analysis. CONCLUSION: It is concluded that the study methodology was helpful in eliciting management priorities and could be applied elsewhere with due adjustment of content regarding selection of concept and their grouping.

Susceptibility of asthmatic children to respiratory infection.

OBJECTIVE: A case-control study of patients with pneumonia was conducted to investigate whether wheezing diseases could be a risk factor. METHODS: A random sample was taken from a general university hospital in S. Paulo City between March and August 1994 comprising 51 cases of pneumonia paired by age and sex to 51 non-respiratory controls and 51 healthy controls. Data collection was carried out by two senior paediatricians. Diagnoses of pneumonia and presence of wheezing disease were independently established by each paediatrician for both cases and controls. Pneumonia was radiologically confirmed and repeatability of information on wheezing diseases was measured. Logistic regression analysis was used to identify risk factors. RESULTS: Wheezing diseases, interpreted as proxies of asthma, were found to be an important risk factor for pneumonia with an odds ratio of 7.07 (95% CI = 2.34-21.36), when the effects of bedroom crowding (odds ratio = 1.49 per person, 95% CI = 0.95-2.32) and of low family income (odds ratio = 5.59 against high family income, 95% CI = 1.38-22.63) were controlled. The risk of pneumonia attributable to wheezing diseases is tentatively calculated at 51.42%. CONCLUSION: It is concluded that at practice level asthmatics should deserve proper surveillance for infection and that at public health level pneumonia incidence could be reduced if current World Health Organisation's guidelines were reviewed as to include comprehensive care for this illness.