RESUMO
The results of the study of the parameters of the immune system in persons suffering from frequent infections, bacteriocarriers and persons with nonspecific infections are presented. The study revealed that T-cell deficiency of the 2nd and 3rd degrees could be regarded as the universal marker of decreased immune reactiveness. Sodium nucleinate was found to be capable of stimulating the T-cell element of immunity and antibody formation, which made it possible to achieve a considerable decrease in morbidity rate. Sodium nucleinate was shown to be highly effective in the prophylaxis of acute respiratory viral infections, carrier state and in the sanitation of purulent foci of infection.
Assuntos
Infecções Bacterianas/imunologia , Linfócitos T/imunologia , Doença Aguda , Adjuvantes Imunológicos/administração & dosagem , Adolescente , Adulto , Infecções Bacterianas/tratamento farmacológico , Infecções Bacterianas/prevenção & controle , Biomarcadores , Portador Sadio/tratamento farmacológico , Portador Sadio/imunologia , Portador Sadio/prevenção & controle , Criança , Pré-Escolar , Doença Crônica , Feminino , Humanos , Lactente , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Militares , Ácidos Nucleicos/administração & dosagem , Federação RussaAssuntos
Adjuvantes Imunológicos/uso terapêutico , Doenças do Sistema Imunitário/prevenção & controle , Ácidos Nucleicos/uso terapêutico , Animais , Toxinas Bacterianas , Clostridium perfringens , Modelos Animais de Doenças , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Cobaias , Humanos , Doenças do Sistema Imunitário/etiologia , Doenças do Sistema Imunitário/imunologia , Cazaquistão , Camundongos , Doenças Profissionais/imunologia , Doenças Profissionais/prevenção & controle , Petróleo , Federação RussaRESUMO
During the first day in space the rhesus monkey, called Vernyi, flown on Cosmos-1667 showed higher values of the daytime, night, and daily respiratory sinus arrhythmia (RSA) when compared to those observed before launch and before or the first day of a simulation study. During orbital flight, the mean daily value of RSA was in the range 13.08-16.00 beats/min. In the simulation study, this parameter increased from 4.68 beats/min during the first day to 15.16 beats/min on the 6th day. The mean RSA values during days 1 through 3 were significantly higher in real than in simulation flight. Analysis of rheopneumograms revealed a correlation between respiration parameters and RSA variations. In space, there was no correlation between RSA and HR, which was reported in the simulation study (r = -0.625). Assuming that RSA is a noninvasive indicator of parasympathetic control over cardiac rhythm, it can be postulated that the primate body adapted to microgravity via activation of parasympathetic mechanisms controlling the heart function.
Assuntos
Modelos Animais de Doenças , Pulmão/inervação , Macaca mulatta/fisiologia , Fenômenos Fisiológicos Respiratórios , Síndrome do Nó Sinusal/etiologia , Nó Sinoatrial/fisiopatologia , Voo Espacial , Nervo Vago/fisiopatologia , Ausência de Peso/efeitos adversos , Animais , Ritmo Circadiano/fisiologia , Fatores de TempoRESUMO
Before and after space flight on Cosmos-1887 motor activity of Trigonoscelis gigas beetles kept in darkness was recorded. After flight 6 out of 7 beetles showed reduction of periods of free running circadian rhythms. The fact that the change was not observed in controls suggests that it can be attributed to the effects of O G. It is assumed that in space flight the biological requirements for the day duration are modified.