Trends and risk factors for obesity among HIV positive Nigerians on antiretroviral therapy.

INTRODUCTION: The increased access to antiretroviral therapy has changed the once deadly infection to a chronic medical condition, resulting in a dramatic change in causes of morbidity and mortality among HIV infected individuals. Obesity and its cardiovascular sequelae are increasingly reported in the literature. However, data on the burden, trends and risk factors for obesity are sparse in countries worst hit by the epidemic. OBJECTIVES: To investigate the trend and risk factors for obesity among a cohort of HIV infected adults on antiretroviral therapy. METHODS: We analysed prospectively collected data in an ongoing longitudinal observational study conducted at the HIV treatment centre, Nigerian Institute of Medical Research, Lagos, Nigeria. Patients who started treatment between June 2004 and December 2009, and completed a five year follow up were included in the analysis. Multivariate analysis was used to determine the risk factors for obesity among the cohort. RESULTS: A total of 12 585 adults were enrolled in the treatment programme during the study period. Of which, 8819 (70.1%) met the inclusion criteria. At the start of treatment, 27.0% were either overweight (19.6%) or obese (7.4%) compared to 62.2% that were either overweight (35.7%) or obese (26.5%) at the end of 5 years. The observed differences were statistically significant (p<0.01). Female gender (aOR: 2.2; 95% CI: 1.81-2.67), low baseline BMI less than 20 (aOR: 1.9; 95% CI: 1.3-2.2) and baseline CD4 count less than 350/µl (aOR: 2.51; 95% CI: 2.13 - 3.09) were associated with the development of obesity at multivariate analysis. Type of antiretroviral drug, age, marital status, viral load and haemoglobin level were not associated with obesity after controlling for confounding variables. CONCLUSIONS: Obesity is common among HIV infected Nigerians on antiretroviral therapy and is associated with.

Attitude of rural Nigerian pregnant women to antenatal HIV screening.

OBJECTIVE: To assess the knowledge and attitude of rural Nigerian women to the incorporation of HIV screening as part of the routine antenatal screening test at booking. METHODS: 1 820 women were interviewed using a close ended questionnaire at the antenatal clinic of the Federal Medical Centre (FMC) Owo, Nigeria over a period of 12 months. RESULTS: Though the majority of the women were of low socio-economic status (85.9%) with 20% having less than six years of formal education, 98.6% of them were aware and knowledgeable (89.1%) about HIV/AIDS. The majority (89.9%) of the women accept routine HIV screening as part of antenatal screening. CONCLUSION: Based on the above findings, obstericians practicing in this locality are encouraged to incorporate HIV screening into their antenatal care.

Prevalence and pattern of domestic violence against pregnant Nigerian women.

Five hundred and twenty-two pregnant Nigerians attending the antenatal clinic in two private hospitals in Lagos between January and June 2003 were interviewed using a structured questionnaire about their experiences of domestic violence. One hundred and four women declined to participate; a response rate of 80.1% was obtained. Analysis of the completed questionnaire by 418 respondents showed that 197 (47.1%) women reported a history of abuse. Of the 197 women who reported abuse, 23 (11.7%) experienced abuse for the first time during the current pregnancy, 97 (49.2%) experienced abuse prior to and during the current pregnancy and in the remaining 77 (39.1%) abuse predate the current pregnancy. A total of 120 (28.7%) women experienced some form of abuse during current pregnancy. Although all social and ethnic groups were involved, no association could be established between prevalence and pattern of abuse and sociodemographic characteristics. Verbal abuse was the most common type of abuse reported (52.3%), followed by economic deprivation (30%), physical abuse (25%), threat of violence (10.8%) and forced sex in 14.2%. The perpetrators of the abuse were husband and boyfriend (78.7%), in-laws (31.5%) and other relations (6.1%). The majority of abused women (99.0%) were not ready to report the abuse to the police. In conclusion, domestic violence is common in our environment and health-care providers should be alert to the clues in order to protect the women from further abuse.