Women's Lives Matter-The Critical Need for Women to Prioritize Optimal Physical Activity to Reduce COVID-19 Illness Risk and Severity.

Physical activity (PA) is beneficial for the health and wellness of individuals and societies. During an infectious disease pandemic, such as the one caused by COVID-19, social distancing, quarantines, and lockdowns are used to reduce community spread of the disease. Unfortunately, such nonpharmacological interventions or physical risk mitigation measures also make it challenging to engage in PA. Reduced PA could then trigger physiological changes that affect both mental and physical health. In this regard, women are more likely to experience physical and psychological distress. PA is a safe and effective nonpharmacological modality that can help prevent and manage several mental and physical health problems when performed correctly. PA might even confer benefits that are directly related to decreasing COVID-19 morbidity and mortality in women. In this review, we summarize why optimal PA must be a priority for women during the COVID-19 pandemic. We then discuss chronic COVID-19 illness and its impact on women, which further underscores the need for worldwide preventive health strategies that include PA. Finally, we discuss the importance of vaccination against COVID-19 for women, as part of prioritizing preventive healthcare and an active lifestyle.

Salivary immunoglobulin A in healthy adolescent females: effects of maximal exercise, physical activity, body composition and diet.

BACKGROUND: The primary purpose of this study was to examine the effect of acute maximal exercise (VO2max test) on salivary immunoglobulin A (SIgA) responses in adolescent females. A secondary aim was to examine the relationship between resting SIgA levels and VO2max, physical activity, body composition, and diet. METHODS: Fifty healthy female adolescents completed a laboratory-based VO2max test, assessment of body composition via hydrodensitometry, a validated physical activity questionnaire (PAQ-A), and a three-day food diary. Unstimulated saliva was collected before, and 5 and 120 minutes after VO2max testing. Absolute SIgA (µg/mL) concentration was determined using an enzyme-linked immunosorbent assay. Secretion rate of SIgA (µg/min) was calculated by multiplying absolute SIgA concentration by saliva flow rate (SFR, µL/min). RESULTS: A significant increase in absolute SIgA concentration (146.8±59.2 µg/mL) was noted immediately after VO2max testing (P<0.05) and returned to pre-exercise levels (120.1±54.1 µg/mL) by 120-min post-exercise (P>0.05). No significant VO2max test effects were observed for SIgA secretion rate and SFR (P>0.05). VO2max values (41.92±6.36 mL/kg/min) were correlated with body fat percentage (r=-0.59; P<0.01), PAQ-A total score (r=0.48; P<0.01), and acute changes in absolute SIgA levels (r=0.28; P<0.05). No significant associations were observed between dietary measures and resting SIgA levels or SFR (P>0.05) except for dietary fiber which correlated with resting absolute SIgA concentration (r=0.29; P<0.05). CONCLUSIONS: Findings indicate that acute graded maximal exercise results in a transient increase in absolute SIgA concentration and that these changes are associated with individual VO2max values.

SIgA and Upper Respiratory Syndrome During a College Cross Country Season.

We examined the changes in salivary immunoglobulin A (SIgA) and the incidence of upper respiratory syndrome (URS) throughout a college cross-country season as well as the acute effect of a VO 2max test on SIgA. Subjects were 22 cross country athletes (XC) (20.7±0.3 years) and 23 matched controls (C) (20.4±0.2 years). Saliva samples were collected pre and post VO2max and at four training time points (August - November). Weekly logs indicating S&S of URS from which a total symptom score (TSS) was calculated were collected. There was a significant decrease in SIgA F(1,43)=10.742, p<0.001 and the secretion rate of SIgA F(1,43)=15.617, p<0.001 for XC at time points two through four. XC was also significantly lower than controls in those two variables across those time points. The secretion rate of SIgA and URS were negatively correlated at time point four R2=0.443, F(4,22)=26.9, p=0.001. There was a significant acute post exercise decrease in the secretion rate of SIgA, pre (M=21.44, SEM=3.95) and post (M=14.5, SEM=3.0), t(1,21)=2.185, p=0.039. Prolonged training resulted in decreased mucosal SIgA.

Effects of resistance training on functional ability in elderly individuals.

PURPOSE: Determine the effects of 16 weeks of strength training on measures of functional ability in elderly who are functionally limited. DESIGN: Quasi-experimental trial in which elderly volunteers were assigned to either an exercise group or a control group. PARTICIPANTS: Eighty-seven participants (65-93 years) living independently but with some functional limitations. INTERVENTION: Thirteen different strength training exercises using Thera-Band resistive bands (Hygenic Corporation, Akron, Ohio). The program was 16 weeks in duration, and the frequency was three times per week. Participants exercised in a group setting one time per week and were given a home exercise book to follow for two additional sessions per week. MEASURES: Functional ability was operationalized to include a variety of measures related to functional ability that impact activities of daily living, morbidity, and mortality in the elderly, including upper- and lower-body strength and gait. ANALYSIS: Intervention effects were analyzed using a 2 (groups: exercise group vs. control group) × 3 (time: baseline vs. mid vs. post) analysis of variance. RESULTS: The exercise group demonstrated significant improvements in upper-body strength as measured by biceps curl (F[2,140] = 39.870; p < .05) and lower-body strength as measured by chair sit-to-stand (F[2,124] = 25.887; p < .05). Gait velocity (F[2,140] = 37.317; p < .05) and step length (F[2,140] = 4.182; p < .05) both increased for the exercise group at week 9, but this increase disappeared by week 17. Compared with minimal changes in the control group, the exercise group demonstrated significant improvements in upper-body strength as measured by biceps curl and lower-body strength as measured by chair sit-to-stand. CONCLUSION: Some measures of function ability were improved after a 16-week structured exercise program for functionally limited elderly. Because functional ability has been inversely correlated with short-term morbidity and the need for assisted living among older adults, providing opportunities to exercise is crucial to future functioning and independence of the elderly population.

Racial and socioeconomic disparities in nutrition behaviors: targeted interventions needed.

OBJECTIVE: To compare dietary knowledge, behaviors and self-efficacy of black middle school students of low socioeconomic status with their white counterparts of higher socioeconomic status. DESIGN: Cross-sectional, school-based survey. SETTING: Large metropolitan area in the United States. PARTICIPANTS: Middle school students (1,208 of low socioeconomic and 978 of higher socioeconomic status). MAIN OUTCOME MEASURES: Dietary behaviors, dietary knowledge, and dietary self-efficacy were assessed by questionnaire. ANALYSIS: Differences between black students of low socioeconomic status and white students of higher socioeconomic status in the above variables. RESULTS: Black students of low socioeconomic status scored significantly lower than did white students of higher socioeconomic status on several of the variables. They were more likely to consume empty calorie food, meat, and fried food and less likely to eat fruit, vegetables, dairy products, and grains; they were less knowledgeable about dietary variables; and they had significantly lower self-efficacy regarding their ability to change dietary habits. CONCLUSIONS AND IMPLICATIONS: The results of this study suggest that black students of low socioeconomic status should be targeted for early intervention related to dietary behaviors. This age group is amenable to change, and interventions designed specifically for them may result in lifetime reductions in risk of morbidity and mortality.

A pilot study to examine the effects of a nutrition intervention on nutrition knowledge, behaviors, and efficacy expectations in middle school children.

BACKGROUND: This was a pilot study to determine the impact of the Michigan Model (MM) Nutrition Curriculum on nutrition knowledge, efficacy expectations, and eating behaviors in middle school students. METHODS: The study was conducted in a large metropolitan setting and approved by the Institutional Review Board. The participants for this study were divided into an intervention group (n = 407) and a control group (n = 169). An MM instructor trained health teachers in the use of the curriculum, and the teacher subsequently taught the curriculum to students in the intervention group. A valid and reliable questionnaire was used to determine pre-post differences. It consisted of 3 subscales assessing eating habits, nutrition knowledge, and efficacy expectations toward healthy eating. Subscale scores were analyzed using a 2 groups (intervention vs control) x 2 times (pre vs post) analysis of variance. RESULTS: The intervention group increased their nutrition knowledge at post. There was also a significant main effect for groups in the subscales "Eating Behaviors" and "Efficacy Expectations Regarding Healthy Eating." Subsequent post hoc analysis revealed that the intervention group was significantly more likely to eat fruits and vegetables and less likely to eat junk food than the control group. Students in the intervention group also felt more confident that they could eat healthy. CONCLUSIONS: The results of this pilot study suggest that the MM Nutrition Curriculum delivered by trained professionals resulted in significant positive changes in both nutrition knowledge and behaviors in middle school children. Further research needs to be conducted to determine the long-term impact.

Structured Exercise in Older Adults With Limited Functional Ability: Assessing the Benefits of an Aerobic Plus Resistance Training Program

The authors of this study examined the effects of a 16-week exercise program designed to increase aerobic capacity, muscular strength, and muscular endurance in older adults who reported and exhibited limited functional ability. Participants were randomly assigned to either an exercise (n=39) or a control (n=34) group. Dependent variables tested included measures of fitness (aerobic exercise capacity and isokinetic strength testing of the legs and arms) and measures of functional capacity (time to and off the floor, stair test, chair stand, and bicep curl). At the end of the program, there were significant differences between the exercise and control groups in arm strength, chair stand, and biceps curl. The results of this study indicate functionally limited older adults who maintain a structured exercise program for 16 weeks exhibit increased functional ability.

Ethnic and socioeconomic comparisons of fitness, activity levels, and barriers to exercise in high school females.

The purpose of this study was to determine if high school females differed in individual measures of health-related physical fitness, barriers to exercise, or activity level based on ethnicity or socioeconomic status. A cross-sectional sample consisting of African American (28%), Hispanic (23%), and white (49%) female high school students, 46% from low socioeconomic groups and 54% from moderate or high socioeconomic groups (n = 1314, age = 16.2 +/- 0.9) participated in this study. A 15-question survey instrument assessed barriers to exercise and activity level. The FITNESSGRAM fitness test assessed aerobic capacity and body mass index (BMI), and skinfold calipers were used to assess percent body fat. Significant differences between African Americans, Hispanics, and whites were found on the following dependent variables: BMI, percent fat, mile run, perceived barriers to exercise, and activity level. Significant differences between socioeconomic groups were found on the following dependent variables: percent fat, mile run, activity level, and perceived barriers to exercise. These results suggest that students of minority and low socioeconomic groups should be given separate and different interventions regarding health-related fitness.

Mucosal IgA and URTI in American college football players: a year longitudinal study.

PURPOSE: The purpose of this study was: (a) to evaluate secretory immunoglobulin A (s-IgA) over a 12-month time period in college football players, and (b) to assess which of the commonly used standard methods of reporting s-IgA, either alone or in combination, serves as the best predictor of incidence of upper respiratory tract infection (URTI). METHODS: One hundred college-aged males (75 varsity college football athletes, 25 nonfootball controls) were studied at eight points over a 12-month period. Resting mucosal IgA, protein and osmolality levels were determined from saliva using established procedures. In addition, incidence of URTI over the 12-month study duration was calculated from completed standard research logs. Repeated-measures ANOVA were conducted on the dependent variables and eight separate stepwise multiple regression analyses were conducted to predict the dependent variable "number of colds" by the independent variables, s-IgA, saliva flow rate, secretion rate of s-IgA, protein, s-IgA:protein, osmolality and s-IgA:osmolality at each data collection point. RESULTS: There was a significant main effect for group, time, and the group x time interaction for s-IgA, the secretion rate of s-IgA, and the number of colds. In the regression model, the only variable that made a significant contribution to the variance at all time points was the secretion rate of s-IgA. CONCLUSION: These findings suggest that a season of training in American football results in a significant decrease in both s-IgA and the secretion rate of s-IgA as well as an increase in the incidence of URTI. Among the various methods commonly employed to express s- IgA levels, the secretion rate of s-IgA may be the most useful clinical biomarker to predict the incidence of URTI.

Hydration status of community-dwelling seniors.

BACKGROUND AND AIMS: Dehydration is the most common fluid or electrolyte disorder among older persons. This study was designed to examine the hydration status of community-dwelling seniors. METHODS: Blood and urine samples were collected from 67 independently living volunteers (65-93 yrs) who had functional limitations but no condition that contraindicated 10 min of moderate exercise. Forty-six subjects who were not diabetic, had fasted for 12 hours, and had blood glucose levels < or = 115 mg/dL were thus included. Urine and serum samples were analyzed for osmolality (mosm/kg), Na+ (mmol/L) and K+ (mmol/L). Whole blood was analyzed for hemoglobin (Hb, g/dL) and hematocrit (Hct, %) and urine for specific gravity (USG). Means and standard deviations for the current data were compared with normal values. RESULTS: All values were within normal ranges except urine osmolality. CONCLUSIONS: While changes associated with aging may predispose an individual to dehydration, functionally limited, independently living older individuals demonstrate normal hydration status following a 12-hr fast. This suggests that dehydration is not solely a function of the aging process, but may be more related to concomitant medical conditions or dependent living.

Effects of ginseng on secretory IgA, performance, and recovery from interval exercise.

PURPOSE: This study examined the efficacy of ginseng to modulate secretory immunoglobulin A (SIgA), exercise performance, and recovery from repeated bouts of strenuous physical exertion. METHODS: Using a double-blind, placebo-controlled, randomized design, 38 active healthy adults supplemented their diets with a standardized ginseng concentrate (400 mg.d-1 of G115; equivalent to 2 g of Panax ginseng C.A. Meyer root material) or placebo (lactose) for 8 wk. Before and after the intervention, each subject performed three consecutive 30-s Wingate tests interspersed with 3-min recovery periods under controlled laboratory conditions. SIgA secretion rate (S-SIgA) and the relation of SIgA to total protein were calculated from measures of saliva flow rate (SFR), and absolute SIgA and salivary protein concentrations in timed, whole unstimulated saliva samples collected before and after exercise testing. Peak and mean mechanical power output (W.kg-1) was measured with an infrared-beam optical-sensor array, and exercise recovery heart rate (HRR) was determined electrocardiographically. RESULTS: Twenty-seven subjects (12 placebo, 15 ginseng) completed the study. Compared with rest, S-SIgA, SIgA:protein ratio, and SFR were lower after exercise at baseline (P < 0.05). Similarly, both peak and mean mechanical power output declined (P < 0.01) across consecutive Wingate tests. Postintervention minus preintervention change scores for salivary parameters, exercise performance, and HRR were similar between ginseng- and placebo-treated groups (P > 0.05). CONCLUSION: These findings do not support the hypothesis that ginseng may affect mucosal immunity as indicated by changes in secretory IgA at rest and after an exercise induced state of homeostatic disturbance. Supplementation with ginseng fails to improve physical performance and heart rate recovery of individuals undergoing repeated bouts of exhausting exercise.

Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women.

It has been shown that high levels of high-density lipoprotein (HDL) cholesterol and low levels of low-density lipoprotein (LDL) cholesterol are associated with health maintenance in older women, but the few studies that have examined the relationship between exercise and plasma lipoprotein levels in this elderly population have been equivocal. In addition, there are no studies that examine the plasma lipoprotein response of two different types of exercise in a group of active but nonexercising women. Thus, the effects of exercise training on plasma lipoprotein levels in elderly women remain unclear. The purpose of this research was to examine the effects of endurance and resistance exercise on plasma lipoprotein levels in elderly women who were active but nonexercising prior to the study. A total of 45 healthy, active women, aged 70-87 years, were randomly assigned to either an aerobic training (AT, 76 +/- 5 years, n = 15), resistance training (RT, 73 +/- 3 years, n = 15), or control (C, 74 +/- 5 years, n = 15) group. The AT group walked 3 days a week at 70% heart rate reserve. The duration on day 1 was 20 minutes, and it was increased by 5 minutes each day until subjects were walking for 50 minutes (week 3). The exercise training session for the RT group consisted of one to three sets of eight repetitions of eight different exercises at an eight repetition maximum; the C group maintained normal activity. Weight and diet were unchanged across groups. The exercise interventions lasted 10 weeks. Blood samples were obtained from all subjects at week 0 and week 11. Training resulted in a significant decrease in 1-mile walk times and heart rate at completion of the walk for the AT group and a significant increase in eight repetition maximum of all RT exercises. Both AT and RT groups experienced increased HDL cholesterol and decreased triglycerides at week 11 compared with week 0. There were no positive changes in control lipoproteins. Both triglycerides and the total cholesterol to HDL ratio increased significantly while total cholesterol, HDL cholesterol, and LDL cholesterol remained unchanged. The RT group also had significantly lower LDL cholesterol and total cholesterol compared with controls at week 11. Both RT and endurance training resulted in favorable changes to plasma lipoprotein levels for elderly women in only 10 weeks. The fact that this occurred without concurrent changes in weight or diet is an indication that high-intensity exercise alone can be used to modify lipoproteins in populations of healthy elderly women.