Dual-functional Hydroxyapatite scaffolds for bone regeneration and precision drug delivery.

Addressing infected bone defects remains a significant challenge in orthopedics, requiring effective infection control and bone defect repair. A promising therapeutic approach involves the development of dual-functional engineered biomaterials with drug delivery systems that combine antibacterial properties with osteogenesis promotion. The Hydroxyapatite composite scaffolds offer a one-stage treatment, eliminating the need for multiple surgeries and thereby streamlining the process and reducing treatment time. This review delves into the impaired bone repair mechanisms within pathogen-infected and inflamed microenvironments, providing a theoretical foundation for treating infectious bone defects. Additionally, it explores composite scaffolds made of antibacterial and osteogenic materials, along with advanced drug delivery systems that possess both antibacterial and bone-regenerative properties. By offering a comprehensive understanding of the microenvironment of infectious bone defects and innovative design strategies for dual-function scaffolds, this review presents significant advancements in treatment methods for infectious bone defects. Continued research and clinical validation are essential to refine these innovations, ensuring biocompatibility and safety, achieving controlled release and stability, and developing scalable manufacturing processes for widespread clinical application.

Optimizing Wound Healing: Examining the Influence of Biopolymers Through a Comprehensive Review of Nanohydrogel-Embedded Nanoparticles in Advancing Regenerative Medicine.

Nanohydrogel wound healing refers to the use of nanotechnology-based hydrogel materials to promote the healing of wounds. Hydrogel dressings are made up of a three-dimensional network of hydrophilic polymers that can absorb and retain large amounts of water or other fluids. Nanohydrogels take this concept further by incorporating nanoscale particles or structures into the hydrogel matrix. These nanoparticles can be made of various materials, such as silver, zinc oxide, or nanoparticles derived from natural substances like chitosan. The inclusion of nanoparticles can provide additional properties and benefits to the hydrogel dressings. Nanohydrogels can be designed to release bioactive substances, such as growth factors or drugs, in a controlled manner. This allows for targeted delivery of therapeutics to the wound site, promoting healing and reducing inflammation. Nanoparticles can reinforce the structure of hydrogels, improving their mechanical strength and stability. Nanohydrogels often incorporate antimicrobial nanoparticles, such as silver or zinc oxide. These nanoparticles have shown effective antimicrobial activity against a wide range of bacteria, fungi, and other pathogens. By incorporating them into hydrogel dressings, nanohydrogels can help prevent or reduce the risk of infection in wounds. Nanohydrogels can be designed to encapsulate and release bioactive substances, such as growth factors, peptides, or drugs, in a controlled and sustained manner. This targeted delivery of therapeutic agents promotes wound healing by facilitating cell proliferation, reducing inflammation, and supporting tissue regeneration. The unique properties of nanohydrogels, including their ability to maintain a moist environment and deliver bioactive agents, can help accelerate the wound healing process. By creating an optimal environment for cell growth and tissue repair, nanohydrogels can promote faster and more efficient healing of wounds.

Design of bone scaffolds with calcium phosphate and its derivatives by 3D printing: A review.

Tissue engineering is a fascinating field that combines biology, engineering, and medicine to create artificial tissues and organs. It involves using living cells, biomaterials, and bioengineering techniques to develop functional tissues that can be used to replace or repair damaged or diseased organs in the human body. The process typically starts by obtaining cells from the patient or a donor. These cells are then cultured and grown in a laboratory under controlled conditions. Scaffold materials, such as biodegradable polymers or natural extracellular matrices, are used to provide support and structure for the growing cells. 3D bone scaffolds are a fascinating application within the field of tissue engineering. These scaffolds are designed to mimic the structure and properties of natural bone tissue and serve as a temporary framework for new bone growth. The main purpose of a 3D bone scaffold is to provide mechanical support to the surrounding cells and guide their growth in a specific direction. It acts as a template, encouraging the formation of new bone tissue by providing a framework for cells to attach, proliferate, and differentiate. These scaffolds are typically fabricated using biocompatible materials like ceramics, polymers, or a combination of both. The choice of material depends on factors such as strength, biodegradability, and the ability to facilitate cell adhesion and growth. Advanced techniques like 3D printing have revolutionized the fabrication process of these scaffolds. Using precise layer-by-layer deposition, it allows for the creation of complex, patient-specific geometries, mimicking the intricacies of natural bone structure. This article offers a brief overview of the latest developments in the research and development of 3D printing techniques for creating scaffolds used in bone tissue engineering.

Design, fabrication, evaluation, and in vitro study of green biomaterial and antibacterial polymeric biofilms of polyvinyl alcohol/tannic acid/CuO/ SiO2.

In this study, a three-component biofilm for rapid wound dressing consisting of polyvinyl alcohol (PVA)/tannic acid (TA)/with CuO/SiO2 with different percentages (0, 5, 10, and 15 wt% NPs) is evaluated. In addition to controlling bleeding and absorption of blood and wound secretions, it protects the damaged tissue from the attack of microbes. It protects against viruses and thus reduces the treatment time. Analysis of biofilms morphology is performed by Field emission scanning electron microscopy (FE-SEM), phases in biofilms were analyzed by X-ray diffraction (XRD) analysis, chemical bonds, and functional groups are analyzed by Fourier transform infrared (FTIR) spectroscopy, and mechanical tests are performed to evaluate the strength of the samples. The thermogravimetric analysis (TGA) is applied to estimate the thermal stability of the biopolymer films with various percentages of CuO/SiO2 nanoparticles. Also, antibacterial test, bioactivity of the biofilms, the percentage of swelling ratio, and porosity of the samples were examined by immersing the samples in simulated body fluid (SBF) and Phosphate-buffered saline (PBS) for 14 days in vitro. The composite makeup of the TA/PVA sample, comprising 15 wt % CuO/SiO2 and containing 15 wt% of nanoparticles, exhibited superior heat resistance compared to other samples by an increase of 50 °C. This improvement can be attributed to the nanoparticles reaching their saturation point. The swelling ratio was assessed in both SBF and PBS, and in both instances, the sample increased by up to 10 wt% before decreasing, indicating the saturation of the nanoparticles.

The effect of increasing temperature on simulated nanocomposites reinforced with SWBNNs and its effect on characteristics related to mechanics and the physical attributes using the MDs approach.

This study examines the effect of increasing temperature (300, 350, 400, 450 and 500 K) on simulated nanocomposites reinforced with exploration of the impact of single-walled boron nitride nanotubes (SWBNNTs) on both the mechanical properties (including Young's modulus, Poisson's ratio, shear modulus, and bulk modulus) and the physical property of density, achieved through molecular dynamics (MDs) simulations. MDs utilized to simulate nanocomposite models consisting of five case studies of SWBNNs with different chiralities (5, 0), (10, 0), (15, 0), (20, 0), and (25, 0) as the reinforcement and using thermoplastic polyurethane (TPU) as the common matrix. The results reveal that with increasing temperature and chiralities of SWBNNTs, the density and Poisson's ratio increase dramatically, and Young's, shear, and bulk moduli decrease continuously. At a consistent temperature, there is a noteworthy trend in the mechanical properties of SWBNNTs with various chiralities. This includes the increase in Young's modulus, Poisson's ratio, shear modulus, and bulk modulus in the simulated nanocomposite, ranging from SWBNNTs (5, 0) to (25, 0). Similarly, the physical property of density exhibits an increasing trend from SWBNNTs (5, 0) to (20, 0) and then decreases at SWBNNTs (25, 0). To validate the accuracy of these findings, a Radial Distribution Function (RDF) diagram is generated using Materials Studio software.

Explore the most recent advancements in the domain of self-healing intelligent composites specifically designed for use in dentistry.

Dental composites are commonly utilized in dental treatments because they have the ability to preserve the natural appearance of teeth, are minimally invasive and conservative, and enhance the overall physical and mechanical attributes. Dental composites can experience damage, like small cracks, due to factors like temperature changes and physical strain, which can reduce their effectiveness. Detecting these tiny cracks in dental composites can be quite challenging, and in certain situations, it may even be impossible. In addition, it is not possible to repair these damages in situ by using conventional materials and methods. Therefore, the self-healing ability in dental composites is necessary. In recent years, the spontaneous repair of damages such as micro-cracking in dental composite materials has been developed without any type of human intervention and the replacement of new components. The most widely used approach to create self-healing dental composites involves encapsulating a healing agent within polymer shells and dispersing these microcapsules within the acrylate matrix of the dental composite. To assess the self-healing abilities of these composites, researchers can examine changes in their fracture toughness before and after the healing process using a test called the Single Edge V-notch beam test. In the present article we reviewed the latest findings in the field of self-healing intelligent composites for application in dentistry, and also in the present study, the studies on self-healing smart dental composites will be reviewed.

Natural biomarocmolecule-based antimicrobial hydrogel for rapid wound healing: A review.

Antibacterial hydrogels are a type of hydrogel that is designed to inhibit the growth of bacteria and prevent infections. These hydrogels typically contain antibacterial agents that are either integrated into the polymer network or coated onto the surface of the hydrogel. The antibacterial agents in these hydrogels can work through a variety of mechanisms, such as disrupting bacterial cell walls or inhibiting bacterial enzyme activity. Some examples of antibacterial agents that are commonly used in hydrogels include silver nanoparticles, chitosan, and quaternary ammonium compounds. Antibacterial hydrogels have a wide range of applications, including wound dressings, catheters, and medical implants. They can help to prevent infections, reduce inflammation, and promote tissue healing. In addition, they can be designed with specific properties to suit different applications, such as high mechanical strength or controlled release of antibacterial agents over time. Hydrogel wound dressings have come a long way in recent years, and the future looks very promising for these innovative wound care products. Overall, the future of hydrogel wound dressings is very promising, and we can expect to see continued innovation and advancement in this field in the years to come.

Flexible self-healing nanocomposite based gelatin/tannic acid/acrylic acid reinforced with zinc oxide nanoparticles and hollow silver nanoparticles based on porous silica for rapid wound healing.

In this research, gelatin (Ge), tannic acid (TA), acrylic acid (AA) as a matrix are used. Zinc oxide (ZnO) nanoparticles (10, 20, 30, 40 and 50 wt%) and hollow silver nanoparticles along with ascorbic acid (1, 3, and 5 wt%) are considered as reinforcement. In order to prove the functional groups of nanoparticles made from Fourier-transform infrared spectroscopy (FTIR), and determine the existing phases of the powders in the hydrogel, X-ray diffraction (XRD) is used, also to investigate the morphology, size, and porosity of the holes and in the scaffolds, scanning electron microscope analysis is used (FESEM). Then, mechanical tests such as tension and compression test are performed to determine the most optimal state of the composite. Also, the antibacterial test is performed for the manufactured powders and hydrogel, as well as the toxicity test for the fabricated hydrogel. The results show that the sample (30 wt% of zinc oxide and 5 wt% of hollow nanoparticles) is the most optimal hydrogel based on mechanical tests and biological properties.

Design, preparation, and characterization of CS/PVA/SA hydrogels modified with mesoporous Ag2O/SiO2 and curcumin nanoparticles for green, biocompatible, and antibacterial biopolymer film.

One of the most significant factors affecting the rapid and effective healing of wounds is the application of appropriate wound dressings. In the present study, novel antibacterial wound dressings are fabricated that consist of Chitosan (CS)/Polyvinyl alcohol (PVA)/Sodium Alginate (SA), which are all biocompatible, functionalized with mesoporous Ag2O/SiO2 and curcumin nanoparticles as reinforcements. In this research nanocomposites are fabricated (0 wt%, 5 wt%, 10 wt%, 15 wt%, and 20 wt% of Ag2O/SiO2). After the composition of nanocomposites using the cross-linked technique, Fourier Transform Infrared (FT-IR) spectroscopy is performed to confirm the functional groups that are added to the polymer at each step. X-ray diffraction (XRD) is done to show the crystallinity of Ag2O/SiO2. Field emission scanning electron microscopy (FE-SEM) studies are performed to demonstrate the morphology of the structure, Energy-dispersive X-ray spectroscopy (EDS) is done to examine the elements in the wound dressing and atomic force microscopy (AFM) study is performed to show surface roughness and pores. Then the nanocomposites with different weight percentages are cultured in three bacteria called Acinetobacter baumannii, Staphylococcus epidermidis, and Proteus mirabilis, all three of which cause skin infections. Finally, by performing the tensile test, the results related to the tensile strength of the wound dressings are examined. The results show that with the increase of Ag2O/SiO2, the mechanical properties, as well as the healing properties of the wound dressing, have increased significantly. Fabricating these nanocomposites helps a lot in treating skin infections.