Status of Hearing Impairment among Handloom Workers in Tangail District of Bangladesh.

Industrial noise is one of the major sources of noise pollution. Handloom industry is the biggest handicraft industry in our country; it is the second largest source of rural employment after agriculture. The workers of the handloom industry worked within excessive level of sound. This cross-sectional study was an attempt to see the status of hearing impairment among handloom worker at Tangail District, Bangladesh from August 2016 to December 2016. A total 180 handloom workers were included in this current study. All the respondents were male as handloom work is a strenuous work. The mean age of respondents was 38.18±11.529 years where most of the respondents were of middle age group (21-50) year's age group. Among the participants less than one-fourth was illiterate and rest had primary to secondary level of education. The average income of handloom workers was 13805.56±2764.696 BDT per month. Handloom workers spend average 10 hour for working per day. They were exposed to sound beyond NIOSH recommendation (70-83 dB around handloom machines and 80-90 dB around power loom machines). By self-assessment hearing impairment perception 76.7% participants reported that they had hearing problem. Based on the interpretation of Rinne, Webers and ABC test data indicate that among the respondents around 32.2% were identified with bilateral sensorineural hearing impairment and of them through Pure tone audiometry (PTA) around half were diagnosed as suffering from moderate to severe Noise induced hearing loss (NIHL). Using personal protective measure like ear muffle/ear musk has been recommended.

Delta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA).

BACKGROUND AND OBJECTIVE: Lead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and individual susceptibility. As children are more susceptible to lead-induced toxicity, this study investigated whether the ALAD genotype influenced urinary excretion of delta-aminolevulinic acid (U-ALA) among children exposed to environmental lead in Bangladesh. METHODS: Subjects were elementary schoolchildren from a semi-urban industrialized area in Bangladesh. A total of 222 children were studied. Blood and urine were collected to determine ALAD genotypes, blood lead levels and urinary aminolevulinic acid (U-ALA). RESULTS: The mean BPb level was 9.7 µg/dl for the study children. BPb was significantly positively correlated with hemoglobin (p<0.01). In total, allele frequency for ALAD 1 and 2 was 0.83 and 0.17 respectively. The mean U-ALA concentration was lower in ALAD1-2/2-2 carriers than ALAD1-1 carriers for boys (p=0.001). But for girls, U-ALA did not differ significantly by genotype (p=0.26). When U-ALA was compared by genotype at the same exposure level in a multiple linear regression analysis, boys who were ALAD1-2/2-2 carriers still had a lower level of U-ALA compared to ALAD1-1 carriers. CONCLUSION: This study provides information about the influence of ALAD polymorphism and its association with U-ALA in Bangladeshi children. Our results indicate that the ALAD1-2/2-2 genotype may have a protective effect in terms of U-ALA for environmentally lead exposed boys.

Blood lead levels and health problems of lead acid battery workers in Bangladesh.

INTRODUCTION: Use of lead acid battery (LAB) in Bangladesh has risen with sharp rise of motor vehicles. As result, manufacture of LAB is increasing. Most of the lead used by these industries comes from recycling of LAB. Workers in LAB industry are at risk of exposure lead and thus development of lead toxicity. OBJECTIVE: The objective of this study was to measure the blood lead concentration and to assess the magnitude of health problems attributable to lead toxicity among the LAB manufacturing workers. METHODS: A cross-sectional study was conducted among the workers of LAB manufacturing industries located in Dhaka city. RESULT: Mean blood lead level (BLL) among the workers was found to be high. They were found to be suffering from a number of illnesses attributable to lead toxicity. The common illnesses were frequent headache, numbness of the limbs, colic pain, nausea, tremor, and lead line on the gum. High BLL was also found to be related to hypertension and anemia of the workers. CONCLUSION: High BLL and illnesses attributable to lead toxicity were prevalent amongst workers of the LAB manufacturing industries, and this requires attention especially in terms of occupational hygiene and safety.

Electrocardiographic abnormalities among arsenic-exposed persons through groundwater in Bangladesh.

This study was carried out among arsenic-exposed and non-exposed people of Bangladesh to assess and compare their cardiac status based on electrocardiographic (ECG) findings. For the purpose of the study, participants were included in three groups: arsenic-exposed persons with arsenicosis (arsenicosis group), arsenic-exposed persons without arsenicosis (non-arsenicosis group), and persons not exposed to arsenic (non-exposed group). Each group included 50 respondents. In this study, no significant difference in heart rate, rhythm, axis, and pulse rate interval was detected among the arsenicosis, non-arsenicosis and non-exposed groups. A significant difference in corrected QT interval between the arsenicosis and the non-exposed group (p<0.05) was observed. On the contrary, no statistically significant difference in corrected QT interval between the non-arsenicosis and the non-exposed group was found. Abnormal QRS complex was found among 14%, 8%, and 2% of the arsenicosis, non-arsenicosis, and non-exposed groups respectively. ECG findings, indicative of left ventricular hypertrophy, ischaemic heart disease, and right bundle branch block, were high among the arsenicosis group. Overall, abnormal ECG findings were high (58%) among the respondents of the arsenicosis group and were highly significant (p<0.001). The findings revealed that there was a significant association between ECG abnormalities and arsenic exposure.

Arsenic in drinking water and pregnancy outcomes.

We studied a group of women of reproductive age (15-49 years) who were chronically exposed to arsenic through drinking water to identify the pregnancy outcomes in terms of live birth, stillbirth, spontaneous abortion, and preterm birth. We compared pregnancy outcomes of exposed respondents with pregnancy outcomes of women of reproductive age (15-49 years) who were not exposed to arsenic-contaminated water. In a cross-sectional study, we matched the women in both exposed and nonexposed groups for age, socioeconomic status, education, and age at marriage. The total sample size was 192, with 96 women in each group (i.e., exposed and nonexposed). Of the respondents in the exposed group, 98% had been drinking water containing [Greater and equal to] 0.10 mg/L arsenic and 43.8% had been drinking arsenic-contaminated water for 5-10 years. Skin manifestation due to chronic arsenic exposure was present in 22.9% of the respondents. Adverse pregnancy outcomes in terms of spontaneous abortion, stillbirth, and preterm birth rates were significantly higher in the exposed group than those in the nonexposed group (p = 0.008, p = 0.046, and p = 0.018, respectively).

The relationship of arsenic levels in drinking water and the prevalence rate of skin lesions in Bangladesh.

To determine the relationship of arsenic-associated skin lesions and degree of arsenic exposure, a cross-sectional study was conducted in Bangladesh, where a large part of the population is exposed through drinking water. Four villages in Bangladesh were identified as mainly dependent on wells contaminated with arsenic. We interviewed and examined 1,481 subjects [Greater/equal to] 30 years of age in these villages. A total of 430 subjects had skin lesions (keratosis, hyperpigmentation, or hypopigmentation). Individual exposure assessment could only be estimated by present levels and in terms of a dose index, i.e., arsenic levels divided by individual body weight. Arsenic water concentrations ranged from 10 to 2,040 microg/L, and the crude overall prevalence rate for skin lesions was 29/100. After age adjustment to the world population the prevalence rate was 30. 1/100 and 26.5/100 for males and females, respectively. There was a significant trend for the prevalence rate both in relation to exposure levels and to dose index (p < 0.05), regardless of sex. This study shows a higher prevalence rate of arsenic skin lesions in males than females, with clear dose-response relationship. The overall high prevalence rate in the studied villages is an alarming sign of arsenic exposure and requires an urgent remedy.

Hypertension and arsenic exposure in Bangladesh.

-A prevalence comparison of hypertension among subjects with and those without arsenic exposure through drinking water was conducted in Bangladesh to confirm or refute an earlier observation of a relation in this respect. Wells with and without present arsenic contamination were identified, and we interviewed and examined 1595 subjects who were depending on drinking water from these wells for living, all >/=30 years of age. The interview was based on a questionnaire, and arsenic exposure was estimated from the history of well-water consumption and current arsenic levels. Of the 1595 subjects studied, 1481 had a history of arsenic-contaminated drinking water, whereas 114 had not. Time-weighted mean arsenic levels (in milligrams per liter) and milligram-years per liter of arsenic exposure were estimated for each subject. Exposure categories were assessed as <0.5 mg/L, 0.5 to 1.0 mg/L, and >1.0 mg/L and alternatively as <1.0 mg-y/L, 1.0 to 5.0 mg-y/L, >5.0 but 10.0 mg-y/L, respectively. Hypertension was defined as a systolic blood pressure of >/=140 mm Hg in combination with a diastolic blood pressure of >/=90 mm Hg. Corresponding to the exposure categories, and using "unexposed" as the reference, the prevalence ratios for hypertension adjusted for age, sex, and body mass index were 1.2, 2.2, 2.5 and 0.8, 1.5, 2.2, 3.0, in relation to arsenic exposure in milligrams per liter and milligram-years per liter, respectively. The indicated dose-response relationships were significant (P<<0.001) for both series of risk estimates. These results suggest that arsenic exposure may induce hypertension in humans.

Arsenicosis: sex differentials.

PIP: This cross-sectional study aimed to identify sex differentials in the occurrence of arsenicosis, with particular reference to women in Nilkanda, an arsenic-affected village in Bangladesh. Data were collected from 200 respondents (90 females and 110 males over 10 years of age) who were categorized into arsenic exposed (n = 167) and unexposed (n = 33) groups. The first group was composed of subjects who had been drinking water with arsenic levels 0.05 mg/l for at least 2 years; the second group comprised subjects who had been drinking water with arsenic levels 0.01 mg/l. The exposed group was further divided into arsenicosis (n = 111) and non-arsenicosis (n = 56) subgroups. The mean weight of the unexposed subjects (51.9 kg), the non-arsenicosis subjects (49.4 kg), and the arsenicosis subjects (46.1 kg) was found to be in decreasing order. The amount of daily water intake was significantly higher in both male (3.8 l) and female (3.1 l) arsenicosis subjects compared with the non-arsenicosis group (2.9 l). The female arsenicosis patients were found to be associated with comparatively low concentration of arsenic in tube well water. The majority of female arsenicosis patients was illiterate and their body weight (43.2 kg) was significantly lower compared to the unexposed group (48.9 kg). A significantly low dose (1.321 mg) of arsenic intake was found among exposed female subjects compared to exposed male subjects (1.734 mg). These findings indicate that females are more susceptible to toxic effects of chronic arsenic exposure and are thus likely to suffer from adverse pregnancy outcomes.^ieng