[Use of flunarizine in mild-to-severe senile cerebral deterioration]. / Studio sull'impiego della flunarizina nel deterioramento cerebrale senile di grado medio-lieve.

Within the framework of multifactorial etiology the use of calcium entry blockers as a complementary measure in the management of moderate-to-severe senile brain deterioration has been studied. Clinical study of twelve flunarizine-treated patients has yielded promising evidence in favor of vasoactive drugs as adjuvants to treatment with psychoactive drugs. Further studies should lend support to this hypothesis.

[A case of peripheral neuropathy in an acromegalic subject. Pathogenetic considerations]. / Su un caso di neuropatia periferica in soggetto acromegalico. Considerazioni patogenetiche.

A case of acromegaly with peripheral neuropathy characterized by acroparaesthesiae in the median nerve field of both sides is presented. Electrophysiological examination shows bilateral slowing of the motor conduction velocity of the median nerve through the carpal tunnel. The possible pathogenetic mechanisms of the peripheral neuropathy in acromegalic are discussed in the light of the most recent theories about the GH action. Suggestions are made that some associated hormonal disorders diabetes, hyperaldosteronism, hyperthyroidism) can play some part in the neuropathy pathogenesis.