Diagnostic accuracy of artificial intelligence versus manual detection in marginal bone loss around fixed semicolon. a systematic review.

Objectives: The aim of the review is to evaluate the existing precision of artificial intelligence (AI) in detecting Marginal Bone Loss (MBL) around prosthetic crowns using 2-Dimentional radiographs. It also summarises the recent advances and future challenges associated to their clinical application. Methodology: A literature survey of electronic databases was conducted in November 2023 to recognize the relevant articles. MeSH terms/keywords were used to search ("panoramic" OR "pantomogram" OR "orthopantomogram" OR "opg" OR "periapical") AND ("artificial intelligence" OR "deep" OR "machine" OR "automated" OR "learning") AND ("periodontal bone loss") AND ("prosthetic crown") in PubMed database, SCOPUS, COCHRANE library, EMBASE, CINAHL and Science Direct. RESULTS: The searches identified 49 relevant articles, of them 5 articles met the inclusion criteria were included. The outcomes measured were sensitivity, specificity and accuracy of AI models versus manual detection in panoramic and intraoral radiographs. Few studies reported no significant difference between AI and manual detection, whereas majority demonstrated the superior ability of AI in detecting MBL. CONCLUSIONS: AI models show promising accuracy in analysing complex datasets and generate accurate predictions in the MBL around fixed prosthesis. However, these models are still in the developmental phase. Therefore, it is crucial to assess the effectiveness and reliability of these models before recommending their use in clinical practice.

Multitargeted inhibition of key enzymes associated with diabetes and Alzheimer's disease by 1,3,4-oxadiazole derivatives: Synthesis, in vitro screening, and computational studies.

A library of 22 derivatives of 1,3,4-oxadiazole-2-thiol was synthesized, structurally characterized, and assessed for its potential to inhibit α-amylase, α-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and antioxidant activities. Most of the tested compounds demonstrated good to moderate inhibition potential; however, their activity was lower than that of the standard acarbose. Significantly, compound 3f exhibited the highest inhibition potential against α-glucosidase and α-amylase enzymes, with IC50 values of 18.52 ± 0.09 and 20.25 ± 1.05 µM, respectively, in comparison to the standard acarbose (12.29 ± 0.26; 15.98 ± 0.14 µM). Compounds also demonstrated varying degrees of inhibitory potential against AChE (IC50 = 9.25 ± 0.19 to 36.15 ± 0.12 µM) and BChE (IC50 = 10.06 ± 0.43 to 35.13 ± 0.12 µM) enzymes compared to the standard donepezil (IC50 = 2.01 ± 0.12; 3.12 ± 0.06 µM), as well as DPPH (IC50 = 20.98 ± 0.06 to 52.83 ± 0.12 µM) and ABTS radical scavenging activities (IC50 = 22.29 ± 0.18 to 47.98 ± 0.03 µM) in comparison to the standard ascorbic acid (IC50 = 18.12 ± 0.15; 19.19 ± 0.72). The kinetic investigations have demonstrated that the compounds exhibit competitive-type inhibition for α-amylase, noncompetitive-type inhibition for α-glucosidase and AChE, and mixed-type inhibition for BChE. Additionally, a molecular docking study was performed on all synthetic oxadiazoles to explore the interaction details of these compounds with the active sites of the enzymes.

Modeling the epidemic trend of middle eastern respiratory syndrome coronavirus with optimal control.

Since the outbreak of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012 in the Middle East, we have proposed a deterministic theoretical model to understand its transmission between individuals and MERS-CoV reservoirs such as camels. We aim to calculate the basic reproduction number ($ \mathcal{R}_{0} $) of the model to examine its airborne transmission. By applying stability theory, we can analyze and visualize the local and global features of the model to determine its stability. We also study the sensitivity of $ \mathcal{R}_{0} $ to determine the impact of each parameter on the transmission of the disease. Our model is designed with optimal control in mind to minimize the number of infected individuals while keeping intervention costs low. The model includes time-dependent control variables such as supportive care, the use of surgical masks, government campaigns promoting the importance of masks, and treatment. To support our analytical work, we present numerical simulation results for the proposed model.

Analysis of age wise fractional order problems for the Covid-19 under non-singular kernel of Mittag-Leffler law.

The developed article considers SIR problems for the recent COVID-19 pandemic, in which each component is divided into two subgroups: young and adults. These subgroups are distributed among two classes in each compartment, and the effect of COVID-19 is observed in each class. The fractional problem is investigated using the non-singular operator of Atangana Baleanu in the Caputo sense (ABC). The existence and uniqueness of the solution are calculated using the fundamental theorems of fixed point theory. The stability development is also determined using the Ulam-Hyers stability technique. The approximate solution is evaluated using the fractional Adams-Bashforth technique, providing a wide range of choices for selecting fractional order parameters. The simulation is plotted against available data to verify the obtained scheme. Different fractional-order approximations are compared to integer-order curves of various orders. Therefore, this analysis represents the recent COVID-19 pandemic, differentiated by age at different fractional orders. The analysis reveals the impact of COVID-19 on young and adult populations. Adults, who typically have weaker immune systems, are more susceptible to infection compared to young people. Similarly, recovery from infection is higher among young infected individuals compared to infected cases in adults.

Infection and myelodysplasia: A case report of GATA2 deficiency in a South African patient.

Rare diseases often result in delays in diagnosis. It is important to recognize conditions that have features of both inborn errors of immunity and predispose to myeloid neoplasia. Here we report a patient with GATA2 deficiency that presented with disseminated non-tuberculous mycobacterial infection and pancytopenia secondary to myelodysplastic syndrome.

Analysis of SIQR type mathematical model under Atangana-Baleanu fractional differential operator.

In the given manuscript, the fractional mathematical model for the current pandemic of COVID-19 is investigated. The model is composed of four agents of susceptible (S), infectious (I), quarantined (Q) and recovered (R) cases respectively. The fractional operator of Atangana-Baleanu-Caputo (ABC) is applied to the considered model for the fractional dynamics. The basic reproduction number is computed for the stability analysis. The techniques of existence and uniqueness of the solution are established with the help of fixed point theory. The concept of stability is also derived using the Ulam-Hyers stability technique. With the help of the fractional order numerical method of Adams-Bashforth, we find the approximate solution of the said model. The obtained scheme is simulated on different fractional orders along with the comparison of integer orders. Varying the numerical values for the contact rate ζ, different simulations are performed to check the effect of it on the dynamics of COVID-19.

Modeling the transmission dynamics of middle eastern respiratory syndrome coronavirus with the impact of media coverage.

Middle East respiratory syndrome coronavirus has been persistent in the Middle East region since 2012. In this paper, we propose a deterministic mathematical model to investigate the effect of media coverage on the transmission and control of Middle Eastern respiratory syndrome coronavirus disease. In order to do this we develop model formulation. Basic reproduction number R 0 will be calculated from the model to assess the transmissibility of the (MERS-CoV). We discuss the existence of backward bifurcation for some range of parameters. We also show stability of the model to figure out the stability condition and impact of media coverage. We show a special case of the model for which the endemic equilibrium is globally asymptotically stable. Finally all the theoretical results will be verified with the help of numerical simulation for easy understanding.

Modeling the pandemic trend of 2019 Coronavirus with optimal control analysis.

In this work, we propose a mathematical model to analyze the outbreak of the Coronavirus disease (COVID-19). The proposed model portrays the multiple transmission pathways in the infection dynamics and stresses the role of the environmental reservoir in the transmission of the disease. The basic reproduction number R 0 is calculated from the model to assess the transmissibility of the COVID-19. We discuss sensitivity analysis to clarify the importance of epidemic parameters. The stability theory is used to discuss the local as well as the global properties of the proposed model. The problem is formulated as an optimal control one to minimize the number of infected people and keep the intervention cost as low as possible. Medical mask, isolation, treatment, detergent spray will be involved in the model as time dependent control variables. Finally, we present and discuss results by using numerical simulations.

Co-infection of Middle Eastern respiratory syndrome coronavirus and pulmonary tuberculosis.

Co-infection of Middle Eastern respiratory syndrome, coronavirus and tuberculosis, TB has a complex clinical entities that has estimated worldwide; mostly, in the Middle East. Clinical studies have shown that the propagation of disease is faster in (MERS-CoV) and TB co-infection compared to those of mono-infection. Clinical reports have shown that treatment of tuberculosis (TB) increase the risk of (MERS-CoV) reactivation. In this article, we propose an epidemic model to represents the Middle East respiratory syndrome coronavirus and tuberculosis (TB) co-infection. To do this, we first find the basic reproductive number and analyze the stability of the model. The stability conditions are obtained in term of the basic reproductive number. We also study the bifurcation analysis of the model, using the central manifold theory. Sensitivity of the basic reproductive number is performed to understand the most sensitive parameters. Finally, we show the feasibility of the analytical work, by numerical simulation.

Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait.

BACKGROUND: Some strains of Bacteroides fragilis species are associated with diarrhea as a result of enterotoxin production (bft or fragilysin). Fragilysin is activated by C11 protease (fpn) and together with C10 protease (bfp) play a significant role in its invasiveness. The objectives of this study were to investigate the proportion of clinical isolates from extra-intestinal sources that are toxin producers and characterize the genes mediating toxin production. Clinical isolates submitted to our reference laboratory over the last 13 years were screened for toxin production using PCR technique. All stool isolates were excluded. The isolates were tested for their susceptibility to 8 antimicrobial agents by E test. Carbapenem resistance gene cfiA was detected by PCR. RESULTS: A total of 421 B. fragilis isolates were viable. Out of these, bft was detected in 210 (49.9%) isolates. Of the 210 bft-positive isolates, 171 (81.4%), 33 (15.7%) and 6 (2.8%) harbored bft-1, bft-2, and bft-3 genes, respectively. Twenty (9.5%) of the bft-positive strains originated from bloodstream infections. Twenty-five, 20 and 9 strains harbored bfp-1, bfp-2 and bfp-3 gene, respectively. Two, 3, 4 bfp isotypes were detected simultaneously in some of strains. The resistance rates against amoxicillin-clavulanic acid was 32%, clindamycin 62%, cefoxitin 26%, imipenem 11%, meropenem 17%, metronidazole 4%, piperacillin 61% and tigecycline 14%. A chromosomally located cfiA gene that encode metallo-ß-lactamase was identified in only 34 isolates (16.2%). CONCLUSIONS: The prevalence of enterotoxin-producing B. fragilis was high among the extra-intestinal isolates. Metronidazole was the most active agent against all isolates. There was no statistically significance difference between resistance rates among bft-positive and bft-negative isolates except for clindamycin.

Syntheses of 4,6-dihydroxypyrimidine diones, their urease inhibition, in vitro, in silico, and kinetic studies.

A library of 4,6-dihydroxypyrimidine diones (1-35) were synthesized and evaluated for their urease inhibitory activity. Structure-activity relationships, and mechanism of inhibition were also studied. All compounds were found to be active with IC50 values between 22.6±1.14-117.4±0.73µM, in comparison to standard, thiourea (IC50=21.2±1.3µM). Kinetics studies on the most active compounds 2-7, 16, 17, 28, and 33 were performed to investigate their modes of inhibition, and dissociation constants Ki. Compounds 2, 3, 7, 16, 28, and 33 were found to be mixed-type of inhibitors with Ki values in the range of 7.91±0.024-13.03±0.013µM, whereas, compounds 4-6, and 17 were found to be non-competitive inhibitors with Ki values in the range of 9.28±0.019-13.05±0.023µM. In silico study was also performed, and a good correlation was observed between experimental and docking studies. This study is continuation of our previously reported urease inhibitory activity of pyrimidine diones, representing potential leads for further research as possible treatment of diseases caused by ureolytic bacteria.

Synthesis, in vitro ß-glucuronidase inhibitory potential and molecular docking studies of quinolines.

In this study synthesis and ß-glucuronidase inhibitory potential of 3/5/8 sulfonamide and 8-sulfonate derivatives of quinoline (1-40) are discussed. Studies reveal that all the synthetic compounds were found to have good inhibitory activity against ß-glucuronidase. Nonetheless, compounds 1, 2, 5, 13, and 22-24 having IC50 values in the range of 1.60-8.40 µM showed superior activity than the standard saccharic acid 1,4-lactone (IC50 = 48.4 ± 1.25 µM). Moreover, molecular docking studies of selected compounds were also performed to see interactions between active compounds and binding sites. Structures of all the synthetic compounds were confirmed through 1H NMR, EI-MS and HREI-MS spectroscopic techniques.