The association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: A population-based study.

BACKGROUND: The prevalence of dengue infection is increasing globally. There are few prospective population-based surveillance studies of the immunological and inflammatory consequences of exposure to dengue virus in young children. OBJECTIVE: To study the association between serologically confirmed prior medical diagnosis of dengue infection and blood measures of systemic inflammation with dengue virus immunoglobulin G levels. METHODS: A population-based study of healthy three-year old children living in Havana, Cuba. RESULTS: 865 individuals provided a blood sample. Fourteen (1.6%) had a prior medical diagnosis of dengue infection, and 851 individuals had no prior medical diagnosis. There was no difference in the serum immunoglobulin G titres between these groups (Mann-Whitney test, p = 0.49). Total white cell count, blood neutrophil and eosinophil counts were linearly associated with a dengue immunoglobulin G value above the median value. CONCLUSIONS: There was no difference between the dengue immunoglobulin G titres in young children who had previously had clinically proven dengue infection compared to those who had no diagnosis of prior infection. This may be a consequence of a relatively high prevalence of sub-clinical infection. A higher dengue immunoglobulin G level was positively associated with a range of inflammatory biomarkers, although these data cannot demonstrate a causal association.

Costos por medicamentos en la Hidratacion del paciente con diarreas, 1975 y 1989 / Costs by drugs in the hydratation of the patient with diarrhea

Se realiza un estudio retrospectivo y comparativo de los costos por medicamentos utilizados para la hidratacion de pacientes deshidratados por enfermedad diarreica aguda. El estudio incluye el analisis de 400 historias clinicas de pacientes egresados del Servicio de Enfermedades del Hospital Pediatrico de Centro Habana en 1975 y en 1989. La muestra se tomo de forma aleatoria tomando en cuenta el total de egresados en cada ano. Las historias clinicas se estudiaron en 2 grupos de 200 pacientes menores de 3 anos. Los datos se recogieron en un modulo de encuesta y se validaron utilizando el Programa EPI-5. Se hicieron tablas de congruencia a los que se les calculo chi cuadrado (X2) con sus correspondientes grados de libertad y nivel de significacion estadistico (p). Los resultados encontrados se expresan en las tablas y figuras. Lo mas relevante de esta investigacion es haber obtenido una reduccion del 71,8 por ciento en los costos por concepto de medicamentos usados para la hidratacion, que si se aplica a todo el pais nos muestra una disminucion de miles de pesos solo con la aplicacion de esta nueva tecnologia