[Current views on pathogenesis and treatment of neovascular glaucoma]. / Sovremennye vzglyady na patogenez i lechenie neovaskulyarnoi glaukomy.

Neovascular glaucoma is a type of secondary glaucoma characterized by the most severe course, and ranking second among the causes of irreversible blindness. This review summarizes the results of numerous studies devoted to the search for prevention measures and the most effective treatment strategy. The main ways of preventing the development of neovascular glaucoma are timely diagnosis and elimination of ischemic processes in the retina, combined with adequate control of intraocular pressure and treatment of the underlying disease.

[New mathematical method for automating the analysis of fluorescein angiograms of the human fundus]. / Novyi matematicheskii metod avtomatizatsii analiza flyuorestsentnykh angiogramm glaznogo dna cheloveka.

Specific software for digital image analysis is essential for adequate analysis and objectification of ophthalmic images, assessment of the prevalence of the pathological process, as well as for planning the amount of necessary medical intervention in various diseases. PURPOSE: To develop a method for automatic analysis of angiographic images of the fundus for early diagnosis of vascular disorders and complications in a number of ophthalmic diseases. MATERIAL AND METHODS: Initial angiograms of patients (n=117) with vascular eye diseases and in healthy condition were analyzed in automatic mode using a new mathematical approach to digital processing of fundus fluorescein angiograms based on a three-stage algorithm for extracting information from images. RESULTS: A new mathematical method has been developed for the analysis fluorescein angiograms allowing for more complete results than with visual inspection of images, with image processing taking no more than 1 second in automatic mode. CONCLUSION: The developed method is based on fundamental results of the mathematical theory of image analysis and the joint use of image processing methods, mathematical morphology and mathematical statistics. The article introduces software implementations of the developed methods and presents the automated workplace of an ophthalmologist researcher.

[Effects of laser operations in the iris-lens diaphragm area on the thickness of the macular region and peripapillary nerve fiber layer]. / Vliyanie lazernykh operatsii v oblasti iridokhrustalikovoi diafragmy na tolshchinu makulyarnoi oblasti i peripapillyarnogo sloya nervnykh volokon.

All methods of laser radiation therapy currently used in clinical practice are positioned as safe in terms of possible negative effects on the eye and surrounding tissues. PURPOSE: To assess possible changes in the macular region of the retina and thickness of the peripapillary retinal nerve fiber layer (RNFL) according to the results of a dynamic study of OCT parameters after laser operations in the iris-lens diaphragm area. MATERIAL AND METHODS: Optical coherence tomography (OCT) was performed on 34 pseudophakic patients (43 eyes) with clinical signs of secondary cataract with best corrected visual acuity (BCVA) of at least 0.3, and on 28 patients (38 eyes) with relative papillary block before laser intervention and 1 hour, 1 day, 3 days, 7 days, 1 and 6 months after surgery. The changes in the thickness of the retina in 9 standard ETDRS areas, and the thickness of the ganglion cells layer and peripapillary RNFL were analyzed. RESULTS: In both groups of patients during the entire observation period, there was no fundamental change in the thickness of the peripapillary RNFL and the ganglion cell complex (all p>0.05). According to OCT, retinal thickness in both groups significantly increased an hour after laser irradiation in 5 out of 9 ETDRS areas. The retinal thickness returned to preoperative values in the group of patients with Nd:YAG laser posterior capsulotomy on the 3rd day after surgery, and after 1 week in the group with Nd:YAG laser iridectomy. Retinal thickness in the macular area did not change significantly during the follow-up. CONCLUSION: Laser operations in the iris-lens diaphragm area have a negligible effect on the thickness of the retina, as measured by the OCT method, do not affect the thickness of the ganglion cells layer or peripapillary RNFL, and is safe for the central zone of the retina.

[Retinal changes after laser interventions on anterior segment of the eyeball]. / Izmeneniia setchatki posle lazernykh vmeshatel'stv na strukturakh perednego otdela glaza.

Laser surgery of the cornea, iris, angle of the anterior chamber and other parts of anterior segment of the eye sees wide application in clinical practice. The adverse effects it can cause in the anterior segment are well known and understood. At the same time, changes the treatment method can cause in the posterior segment of the eye - primarily, in macular area of the cornea, which is of great importance, have not been studied sufficiently. Purpose of the review - to consolidate previously published data on changes in the retina after laser intervention on the anterior segment of the eye.

[Transpupillary laser photocoagulation of ocular fundus: history, the present, and the future]. / Transpupillyarnaya lazernaya fotokoagulyatsiya tkanei glaznogo dna: proshloe, nastoyashchee i budushchee.

The present review covers the use of chorioretinal photocoagulation, which is now a popular treatment for many diseases of the ocular fundus. The review includes a detailed 50-year history of the technology with account to both Russian and foreign achievements. The current state of the field is shown through Russian and foreign literature data. A particular emphasis is placed on subthreshold, pattern, and navigated techniques. Breakthrough solutions, such as optoacoustic monitoring, that ensure high precision of the procedure, maximum saving of tissues, and high therapeutic effectiveness are described.

[Morphological and histochemical effects of subthreshold laser therapy on the chorioretinal complex].

A variety of subthreshold laser methods that enable selective and precise treatment of chorioretinal microstructures, thus decreasing the risk of negative changes in retina and choriocapillaries, is used in current ophthalmological practice. This comparative pathomorphological and histochemical study allowed characterizing structural changes and functional activity of chorioretinal cells after application of different subthreshold laser technologies.

[Comparative experimental study of morphological and histochemical changes of chorioretinal complex after subthreshold laser exposure].

The influence of several subthreshold laser procedures on chorioretinal complex (CRC) tissues was experimentally studied in rabbits using histological and histochemical methods. Subthreshold micropulse laser radiation and transpupillar thermotherapy were found to have the most attenuated and advantageous effect on CRC structure. The feature of subthreshold laser exposure is partly reversible selective changes in CRC, that have temporary stimulating effect on cellular metabolism and local regenerative processes providing an opportunity for still viable tissues to function adequately.