Anti-SSA/Ro52 autoantibodies in scleroderma: results of an observational, cross-sectional study.

OBJECTIVES: To date, the diagnostic utility of anti-SSA/Ro52 autoantibodies in scleroderma and the association of them with certain clinical manifestations, particularly inflammatory myositis, are still controversial. This paper aims to assess the correlation between the presence of anti-SSA/Ro52 antibodies and the demographic, clinical and prognosis characteristics of patients with systemic sclerosis (SSc). METHODS: This is a retrospective, cross-sectional and observational study in patients with SSc. Baseline demographic and clinical characteristics were recorded. Presence of anti-SSA/Ro52, anti-SSA/Ro, anti-SSB/La, snRNP/Sm, anti-centromere, anti-Scl-70 and anti-PM-Scl were analysed by immunoblot, and antinuclear antibodies (ANA) by indirect immunofluorescence. Statistical analysis was performed with PASW Statics 18 software. RESULTS: A total of 132 consecutive patients with analysis of anti-SSA/Ro52 antibodies were selected from a Spanish cohort of 408 patients with SSc, 87.1% of them being women. About half of patients had the limited form (51.5%), followed by diffused form (18.9%), sclerosis sine scleroderma (22.7%), and pre-scleroderma (6.8%). Prevalence of anti-SSA/Ro52 was 35.6%. No association between anti-SSA/Ro52 and clinical manifestations was found, while detection of anti-SSA/Ro52 was significantly associated with the presence of anti-Ro. CONCLUSIONS: The results of our study show that anti-SSA/Ro52 antibodies are often found in SSc patients. No clinical manifestations, including inflammatory myopathy, were related with anti-SSA/Ro antibodies.

[Complications arising from traumatic brain injuries in a hospital rehabilitation unit: a series of 126 cases]. / Complicaciones de los traumatismos craneoencefálicos en una unidad hospitalaria de rehabilitación: serie de 126 casos.

INTRODUCTION: The consequences of traumatic brain injuries (TBI) are devastating, whether it is in the personal, family, health care or social spheres. Sufferers will have to follow a rehabilitation programme in which we are going to be faced with a large number of medical, neurological and orthopaedic problems that will exert an influence on that programme. AIMS: The aim of this study is to determine the epidemiological data and the gravity of the cases of TBI admitted to our Rehabilitation Unit, to identify medical and orthopaedic problems that occurred during the time patients were in hospital, and also to determine factors and variables that could have an effect on the onset of such complications. PATIENTS AND METHODS: A retrospective descriptive study was conducted in which we surveyed and collected data from 126 case histories chosen at random from the 210 patients admitted to our Rehabilitation Unit between 1999 and 2001. RESULTS: Mean age, 29 years (interval 4 67), ratio of males to females, 4:1. The TBI were due to motorcycle accidents (40%), car accidents (30%) and falls (11.5%). Neurological problems appeared in 63%, the most frequent of which was psychomotor agitation. 14% displayed post traumatic hydrocephalus, and 8% presented post traumatic seizures. Gastro intestinal problems were seen in 41%, the most frequent being constipation. Respiratory problems were found in 36%, and 15.6% of the patients suffered from pneumonia. 8% displayed para articular ossifications. The number of days spent in the ICU and the days in coma were the more highly statistically significant variables associated with the onset of these complications. CONCLUSIONS: The problems presented by TBI patients during their stay in a Hospital Rehabilitation Unit are diverse and complex; the number of days spent in the ICU and the days they are in coma are the variables that can be of most use in predicting the onset of such complications.

[Cerebral palsy in childhood: 250 cases report]. / Paralisis cerebral infantil: estudio de 250 casos.

OBJECTIVE: To know the etiological factors of cerebral palsy (CP) incident during pregnancy and neonatal/perinatal periods. To know evolution of a child with a CP diagnosis. PATIENTS, MATERIAL AND METHODS: Bibliographical review of paediatric and rehabilitation texts and databases in Internet. Elaboration of a data collecting questionnaire for reviewing clinical records of patients treated in Paediatric Rehabilitation between 1996 and 2000. RESULTS: 250 patients records reviewed. Most frequent illnesses during pregnancy: first twelve weeks haemorrhages: 17.9% and diabetes 8.4%. Child birth: preterm births 32%, cephalic presentation 78.8%, caesarean operations 32%. Mean birth weight 2,714 g, low birth weight babies 27.2%. Needed hospitalary treatment 48%. Mean time in incubator: 46 days among preterm and 26.6 among full term. Mean time in intensive care units: 44.4 days among preterm and 22.7 among full term. Associated diagnoses: CRP 8%, birth asphyxia 24%, neonatal jaundice 27.2%, neonatal respiratory distress 24%, neonatal sepsis 10%, congenital cardiological illnesses 2.4%, dismorphia 2.4%, epilepsy in 40%. Diagnostic imaging: atrophy 38.8%, hydrocephalus 29.4%, ischemia 14.9%, haemorrhage 11.6%. No findings in 23.8%. Children were sent to Paediatric Rehabilitation at mean age of 8 months. Most frequent disorders: spastic quadriplegia (36.1%) spastic diplegia (26.5%) and hemiplegia (17%). Mental retardation 55%. School attendance 81.2%. CP postnatal in 5.2%. CONCLUSIONS: Incidence of CP (2.5/1,000 alive new born) hardly avoidable for persistent rates of prematurity and complications in child births. Good quality of life and survival until adult ages.