[Pathogenesis of the uremic syndrome]. / La patogenesi della sindrome uremica.

Chronic Renal Failure is a generalized functional impairment, due to Kidneys inability to maintain volume and composition of body fluids and solutes within normal conditions. In the attempt to point out the pathophysiology of Bright's syndrome, the Authors review the "intact nephron hypothesis" and his functional reserve. The uraemic clinical appearance is a very wide field of investigations and beside their own experience, the Authors present some datas and theories to explain the coming out and the evolution of poliuria and oliguria, hypertension, heart pathology, anemia and bleedings, hormonal and metabolic pathways alterations, calcium and bone diseases and central and peripheral uraemic neuropathy.

Acute effects of tolamolol on renal function in hypertensive patients.

The renal heamodynamic effects of a single i.v. administration of tolamolol were studied in 9 hypertensive subjects. No change of GFR and ERPF was observed after tolamolol, while urine output decreased and urine creatinine concentration increased. A reduction of the heart rate was confirmed. Blood pressure was unchanged.