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1.
Artigo em Inglês | MEDLINE | ID: mdl-36310800

RESUMO

A clinical decision tree was developed using point-of-care characteristics to identify patients with culture-proven sepsis due to extended-spectrum ß-lactamase-producing Enterobacterales (ESBL-PE). We compared its performance with the clinical gestalt of emergency department (ED) clinicians and hospital-based clinicians. The developed tree outperformed ED-based clinicians but was comparable to inpatient-based clinicians.

2.
Nano Lett ; 6(2): 306-12, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16464055

RESUMO

Steric barriers such as collagen I sharply limit interstitial delivery of macromolecular and nanoparticle (NP) based therapeutic agents. Collagenase-linked superparamagnetic NPs overcame these barriers and moved through in vitro extracellular matrix (ECM) at 90 microm h(-1), a rate similar to invasive cells, under the influence of a magnetic field. NP migration in ECM diminished linearly over 5 days. The collagenase-NP construct overcame two of the most significant barriers to nano- and microscale therapeutics deployment: proteolytic enzyme stability was maintained during a clinically useful time frame by immobilization on the NP surface and degradation of interstitial barriers to tissue biodistribution was enabled by the conjugated microbial protease.


Assuntos
Colagenases/química , Campos Eletromagnéticos , Matriz Extracelular/química , Nanoestruturas/química , Animais , Bovinos , Colagenases/efeitos da radiação , Matriz Extracelular/fisiologia , Matriz Extracelular/efeitos da radiação , Imobilização , Técnicas In Vitro , Nanoestruturas/efeitos da radiação , Soroalbumina Bovina/química , Soroalbumina Bovina/efeitos da radiação , Propriedades de Superfície , Fatores de Tempo
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