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1.
Ann Thorac Surg ; 108(3): 792-797, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31055040

RESUMO

BACKGROUND: It has been shown that mitral valve repair is superior to mechanical replacement in children with rheumatic heart disease; however there are limited data on the factors affecting the long-term durability of repaired mitral valves. This study describes outcomes after rheumatic mitral valve repair, with adaptation of a risk score to clarify some novel predictors of repair instability. METHODS: A total of 79 children (median age, 11.4 years) with rheumatic heart disease underwent their first mitral valve surgery between 1997 and 2015. Patients with concomitant aortic and tricuspid repair were included. Mean follow-up time was 7.72 years. Mitral valve deterioration (defined as cardiac death, reoperation, or recurrent moderate to severe valvular disease) was used as a key end point. Preoperative echocardiographs were analyzed and graded with respect to valvular mobility, subvalvular apparatus alteration, and function. RESULTS: All patients underwent successful mitral valve repair. Seven patients died during follow-up. Kaplan-Meier analysis demonstrated survival at 15 years to be 83%. A total of 38 patients were deemed to have deterioration in mitral valve function, with a rate of freedom from deterioration at 15 years of 28%. The presence of an immobile anterior mitral leaflet preoperatively and the technique of posterior patch extension were shown to be significant determinants of mitral valve deterioration. CONCLUSIONS: The outcomes after mitral repair for rheumatic heart disease in the young were in keeping with those reported in previous studies. Although the survival was high, long-term valve stability was poor. These findings suggest that the preoperative finding of a restricted anterior mitral leaflet is a negative predictor of repair durability.


Assuntos
Implante de Prótese de Valva Cardíaca/mortalidade , Implante de Prótese de Valva Cardíaca/métodos , Insuficiência da Valva Mitral/mortalidade , Insuficiência da Valva Mitral/cirurgia , Cardiopatia Reumática/complicações , Adolescente , Fatores Etários , Austrália , Causas de Morte , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Mortalidade Hospitalar , Humanos , Estimativa de Kaplan-Meier , Imagem Cinética por Ressonância Magnética/métodos , Masculino , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/etiologia , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Cardiopatia Reumática/diagnóstico , Medição de Risco , Índice de Gravidade de Doença , Fatores Sexuais , Análise de Sobrevida
2.
Pediatr Infect Dis J ; 38(1): e1-e6, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30256313

RESUMO

BACKGROUND: Globally, there is wide variation in streptococcal titer upper limits of normal (ULN) for antistreptolysin O (ASO) and anti-deoxyribonuclease B (ADB) used as an evidence of recent group A streptococcal infection to diagnose acute rheumatic fever (ARF). METHODS: We audited ASO and ADB titers among individuals with ARF in New Zealand (NZ) and in Australia's Northern Territory. We summarized streptococcal titers by different ARF clinical manifestations, assessed application of locally recommended serology guidelines where NZ uses high ULN cut-offs and calculated the proportion of cases fulfilling alternative serologic diagnostic criteria. RESULTS: From January 2013 to December 2015, group A streptococcal serology results were available for 350 patients diagnosed with ARF in NZ and 182 patients in Northern Territory. Median peak streptococcal titers were similar in both settings. Among NZ cases, 267/350 (76.3%) met NZ serologic diagnostic criteria, whereas 329/350 (94.0%) met Australian criteria. By applying Australian ULN titer cut-off criteria to NZ cases, excluding chorea, ARF definite cases would increase by 17.6% representing 47 cases. CONCLUSIONS: ASO and ADB values were similar in these settings. Use of high ULN cut-offs potentially undercounts definite and probable ARF diagnoses. We recommend NZ and other high-burden settings to use globally accepted, age-specific, lower serologic cut-offs to avoid misclassification of ARF.


Assuntos
Anticorpos Antibacterianos/sangue , Efeitos Psicossociais da Doença , Febre Reumática/epidemiologia , Fatores Socioeconômicos , Infecções Estreptocócicas/epidemiologia , Adolescente , Antiestreptolisina/sangue , Criança , Desoxirribonucleases/imunologia , Feminino , Humanos , Masculino , Nova Zelândia/epidemiologia , Northern Territory/epidemiologia , Estudos Retrospectivos , Febre Reumática/microbiologia , Testes Sorológicos , Infecções Estreptocócicas/imunologia , Streptococcus pyogenes
3.
PLoS One ; 12(5): e0178264, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28562621

RESUMO

OBJECTIVE: In high-burden Australian states and territories, registers of patients with acute rheumatic fever and rheumatic heart disease are maintained for patient management, monitoring of system performance and research. Data validation was undertaken for the Australian Northern Territory Rheumatic Heart Disease Register to determine quality and impact of data cleaning on reporting against key performance indicators: overall adherence, and proportion of patients receiving ≥80% of scheduled penicillin doses for secondary prophylaxis. METHODS: Register data were compared with data from health centres. Inconsistencies were identified and corrected; adherence was calculated before and after cleaning. RESULTS: 2780 penicillin doses were validated; 426 inconsistencies were identified, including 102 incorrect dose dates. After cleaning, mean adherence increased (63.5% to 67.3%, p<0.001) and proportion of patients receiving ≥80% of doses increased (34.2% to 42.1%, p = 0.06). CONCLUSIONS: The Northern Territory Rheumatic Heart Disease Register underestimates adherence, although the key performance indicator of ≥80% adherence was not significantly affected. Program performance is better than hitherto appreciated. However some errors could affect patient management, as well as accuracy of longitudinal or inter-jurisdictional comparisons. Adequate resources are needed for maintenance of data quality in acute rheumatic fever/rheumatic heart disease registers to ensure provision of evidence-based care and accurate assessment of program impact.


Assuntos
Cooperação do Paciente , Sistema de Registros , Cardiopatia Reumática/prevenção & controle , Adulto , Austrália/epidemiologia , Feminino , Humanos , Masculino , Cardiopatia Reumática/epidemiologia
4.
Circulation ; 134(3): 222-32, 2016 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-27407071

RESUMO

BACKGROUND: We investigated adverse outcomes for people with acute rheumatic fever (ARF) and rheumatic heart disease (RHD) and the effect of comorbidities and demographic factors on these outcomes. METHODS: Using linked data (RHD register, hospital, and mortality data) for residents of the Northern Territory of Australia, we calculated ARF recurrence rates, rates of progression from ARF to RHD to severe RHD, RHD complication rates (heart failure, endocarditis, stroke, and atrial fibrillation), and mortality rates for 572 individuals diagnosed with ARF and 1248 with RHD in 1997 to 2013 (94.9% Indigenous). RESULTS: ARF recurrence was highest (incidence, 3.7 per 100 person-years) in the first year after the initial ARF episode, but low-level risk persisted for >10 years. Progression to RHD was also highest (incidence, 35.9) in the first year, almost 10 times higher than ARF recurrence. The median age at RHD diagnosis in Indigenous people was young, especially among males (17 years). The development of complications was highest in the first year after RHD diagnosis: heart failure incidence rate per 100 person-years, 9.09; atrial fibrillation, 4.70; endocarditis, 1.00; and stroke, 0.58. Mortality was higher among Indigenous than non-Indigenous RHD patients (hazard ratio, 6.55; 95% confidence interval, 2.45-17.51), of which 28% was explained by comorbid renal failure and hazardous alcohol use. RHD complications and mortality rates were higher for urban than for remote residents. CONCLUSIONS: This study provides important new prognostic information for ARF/RHD. The residual Indigenous survival disparity in RHD patients, which persisted after accounting for comorbidities, suggests that other factors contribute to mortality, warranting further research.


Assuntos
Febre Reumática/mortalidade , Doença Aguda , Adolescente , Adulto , Idoso , Alcoolismo/epidemiologia , Fibrilação Atrial/epidemiologia , Fibrilação Atrial/etiologia , Criança , Pré-Escolar , Comorbidade , Progressão da Doença , Endocardite/epidemiologia , Endocardite/etiologia , Feminino , Seguimentos , Insuficiência Cardíaca/epidemiologia , Insuficiência Cardíaca/etiologia , Hospitalização/estatística & dados numéricos , Humanos , Lactente , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Havaiano Nativo ou Outro Ilhéu do Pacífico/estatística & dados numéricos , Northern Territory , Modelos de Riscos Proporcionais , Recidiva , Insuficiência Renal/epidemiologia , Cardiopatia Reumática/mortalidade , Fumar/epidemiologia , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/etiologia , Resultado do Tratamento , População Branca/estatística & dados numéricos , Adulto Jovem
5.
BMC Health Serv Res ; 13: 525, 2013 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-24350582

RESUMO

BACKGROUND: Rheumatic heart disease (RHD) remains a major health concern for Aboriginal Australians. A key component of RHD control is prevention of recurrent acute rheumatic fever (ARF) using long-term secondary prophylaxis with intramuscular benzathine penicillin (BPG). This is the most important and cost-effective step in RHD control. However, there are significant challenges to effective implementation of secondary prophylaxis programs. This project aimed to increase understanding and improve quality of RHD care through development and implementation of a continuous quality improvement (CQI) strategy. METHODS: We used a CQI strategy to promote implementation of national best-practice ARF/RHD management guidelines at primary health care level in Indigenous communities of the Northern Territory (NT), Australia, 2008-2010. Participatory action research methods were employed to identify system barriers to delivery of high quality care. This entailed facilitated discussion with primary care staff aided by a system assessment tool (SAT). Participants were encouraged to develop and implement strategies to overcome identified barriers, including better record-keeping, triage systems and strategies for patient follow-up. To assess performance, clinical records were audited at baseline, then annually for two years. Key performance indicators included proportion of people receiving adequate secondary prophylaxis (≥80% of scheduled 4-weekly penicillin injections) and quality of documentation. RESULTS: Six health centres participated, servicing approximately 154 people with ARF/RHD. Improvements occurred in indicators of service delivery including proportion of people receiving ≥40% of their scheduled BPG (increasing from 81/116 [70%] at baseline to 84/103 [82%] in year three, p = 0.04), proportion of people reviewed by a doctor within the past two years (112/154 [73%] and 134/156 [86%], p = 0.003), and proportion of people who received influenza vaccination (57/154 [37%] to 86/156 [55%], p = 0.001). However, the proportion receiving ≥80% of scheduled BPG did not change. Documentation in medical files improved: ARF episode documentation increased from 31/55 (56%) to 50/62 (81%) (p = 0.004), and RHD risk category documentation from 87/154 (56%) to 103/145 (76%) (p < 0.001). Large differences in performance were noted between health centres, reflected to some extent in SAT scores. CONCLUSIONS: A CQI process using a systems approach and participatory action research methodology can significantly improve delivery of ARF/RHD care.


Assuntos
Febre Reumática/tratamento farmacológico , Cardiopatia Reumática/tratamento farmacológico , Gestão da Qualidade Total/métodos , Adolescente , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Criança , Pré-Escolar , Feminino , Serviços de Saúde do Indígena/organização & administração , Serviços de Saúde do Indígena/normas , Humanos , Injeções Intramusculares , Masculino , Havaiano Nativo ou Outro Ilhéu do Pacífico/estatística & dados numéricos , Northern Territory , Penicilina G Benzatina/administração & dosagem , Penicilina G Benzatina/uso terapêutico , Melhoria de Qualidade/organização & administração , Indicadores de Qualidade em Assistência à Saúde , Febre Reumática/prevenção & controle , Cardiopatia Reumática/prevenção & controle , Fatores de Risco , Prevenção Secundária , Gestão da Qualidade Total/organização & administração , Adulto Jovem
6.
Implement Sci ; 8: 119, 2013 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-24098940

RESUMO

BACKGROUND: Variation in effectiveness of continuous quality improvement (CQI) interventions between services is commonly reported, but with little explanation of how contextual and other factors may interact to produce this variation. Therefore, there is scant information available on which policy makers can draw to inform effective implementation in different settings. In this paper, we explore how patterns of change in delivery of services may have been achieved in a diverse range of health centers participating in a wide-scale program to achieve improvements in quality of care for Indigenous Australians. METHODS: We elicited key informants' interpretations of factors explaining patterns of change in delivery of guideline-scheduled services over three or more years of a wide-scale CQI project, and inductively analyzed these interpretations to propose fine-grained realist hypotheses about what works for whom and in what circumstances. Data were derived from annual clinical audits from 36 health centers operating in diverse settings, quarterly project monitoring reports, and workshops with 12 key informants who had key roles in project implementation. We abstracted potential context-mechanism-outcome configurations from the data, and based on these, identified potential program-strengthening strategies. RESULTS: Several context-specific, mechanism-based explanations for effectiveness of this CQI project were identified. These were collective valuing of clinical data for improvement purposes; collective efficacy; and organizational change towards a population health orientation. Health centers with strong central management of CQI, and those in which CQI efforts were more dependent on local health center initiative and were adapted to resonate with local priorities were both favorable contexts for collective valuing of clinical data. Where health centers had prior positive experiences of collaboration, effects appeared to be achieved at least partly through the mechanism of collective efficacy. Strong community linkages, staff ability to identify with patients, and staff having the skills and support to take broad ranging action, were favorable contexts for the mechanism of increased population health orientation. CONCLUSIONS: Our study provides evidence to support strategies for program strengthening described in the literature, and extends the understanding of mechanisms through which strategies may be effective in achieving particular outcomes in different contexts.


Assuntos
Atenção Primária à Saúde/normas , Gestão da Qualidade Total/organização & administração , Austrália , Humanos , Modelos Teóricos , Inovação Organizacional
7.
Aust J Rural Health ; 19(3): 111-7, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21605223

RESUMO

This paper reviews what is known about the challenges of implementing quality improvement programs and draws on data from a systematic continuous quality improvement (CQI) project in remote communities in Australia and Fiji, known as Audit and Best practice for Chronic Disease, to synthesise lessons and discuss the potential for broader application in low and middle income countries, including Pacific Island countries and territories. Although a number of systematic reviews have indicated that quality improvement programs can be effective in changing professional practice and improving the quality of care and patient outcomes, little is known about the key ingredients for change or how services use and implement different strategies to achieve improvements. We identify key features of an innovative CQI model and factors related to implementation that support improvement in diabetes service delivery and intermediate outcomes. Requirements for supporting CQI are identified and the potential for wider application discussed. It is argued that the participatory action research approach supports innovation and broad-based change and the evidence it has produced extends the current knowledge base and facilitates the translation of knowledge into action, for both policy and practice.


Assuntos
Continuidade da Assistência ao Paciente/normas , Serviços de Saúde do Indígena/normas , Melhoria de Qualidade , Gestão da Qualidade Total/organização & administração , Austrália , Doença Crônica , Pesquisa Participativa Baseada na Comunidade , Diabetes Mellitus/terapia , Difusão de Inovações , Prática Clínica Baseada em Evidências , Humanos , Avaliação de Processos e Resultados em Cuidados de Saúde , Ilhas do Pacífico , Indicadores de Qualidade em Assistência à Saúde
8.
Aust Health Rev ; 26(3): 31-42, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-15368818

RESUMO

The need for an integrated and life course approach to the prevention and control of chronic diseases is increasingly being recognised. This paper describes the development of the Northern Territory Preventable Chronic Disease Strategy (PCDS), the strategic framework and evidence base, the design of implementation and monitoring phases, and early outcomes. The PCDS is premised on the belief that the major chronic diseases, and their common underlying risk factors, are potentially preventable. The structural challenges to larger jurisdictions taking such an integrated approach are undoubtedly larger, but the benefits are potentially great. Continuing with a series of vertical programs aimed at each single noncommunicable disease will not deliver the desired national health outcomes.


Assuntos
Doença Crônica , Prestação Integrada de Cuidados de Saúde/organização & administração , Promoção da Saúde/organização & administração , Atenção Primária à Saúde/organização & administração , Prevenção Primária/organização & administração , Doença Crônica/epidemiologia , Comportamento Cooperativo , Educação em Saúde , Política de Saúde , Acessibilidade aos Serviços de Saúde , Necessidades e Demandas de Serviços de Saúde , Humanos , Havaiano Nativo ou Outro Ilhéu do Pacífico , Northern Territory/epidemiologia , Desenvolvimento de Programas
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