Compartment syndrome of the leg after plantaris tendon harvest: a case report.

A case of lower extremity compartment syndrome following plantaris tendon harvest for use as an upper extremity tendon graft is described. Compartment syndrome seems to be a rare complication after plantaris harvest, but expedient management is required to avert adverse sequelae. Exploration of the course of the plantaris tendon may be a viable alternative to the traditional lateral approach in attempting to reverse the condition.

Building a strong nursing organization in a merged, service line structure.

In an increasingly complex healthcare environment, the discipline of nursing is difficult to define. Although a designated "department of nursing" may be absent on the organizational chart, the functional elements of the discipline remain. Nursing leaders will benefit from a framework to define and operationalize the core elements of nursing. The authors offer a five-phase methodology to enable the creation of a strong nursing organization in the face of mergers, service lines, and complex reporting structures.

The caregiver's careshop. A renewal experience for nursing staff.

What are some creative methodologies that staff development educators can use to nurture nursing staff while promoting caring and compassionate behaviors? The authors describe an innovative process used during a 1-day workshop designed to convey caring to nursing staff through a variety of experiences. The overall goal of the session is to provide caregivers with a variety of new "tools" to care for themselves as they deal with multiple stressors in their personal and professional lives.

Measuring difficult temperament the easy way.

In this study, the authors introduce a new measure of infant temperament, the Pictorial Assessment of Temperament (PAT), and provide information about its psychometric qualities based on findings from a study of 132 mothers and infants. The PAT is a 10-item measure of "difficult" temperament that is quick and easy to use and avoids some of the inherent problems in existing paper-and-pencil measures of temperament (e.g., complexity of response choices, dependence on respondents' educational level and verbal skills). It has convergent validity with the Revised Infant Temperament Questionnaire and with observed behavior in a laboratory procedure, moderate reliability and stability over time, and moderate agreement between mothers' and fathers' reports. Predictive validity was demonstrated by significant associations with the children's later disruptive behavior, behavior problems, lack of sociability, and negativity in interactions with their mother. Parent characteristics (agreeableness, extraversion, neuroticism, sensitivity, depression) were not related to scores on the PAT, demonstrating its discriminant validity.

Endotoxin-neutralizing protein protects against endotoxin-induced endothelial barrier dysfunction.

Bacterial lipopolysaccharide induces tyrosine phosphorylation of paxillin, actin reorganization, and opening of the transendothelial paracellular pathway through which macromoles flux. In this study, lipid A was shown to be the bioactive portion of the lipopolysaccharide molecule responsible for changes in endothelial barrier function. We then studied whether endotoxin-neutralizing protein, a recombinant peptide that is derived from Limulus antilipopolysaccharide factor and targets lipid A, could block the effects of lipopolysaccharide on protein tyrosine phosphorylation, actin organization, and movement of 14C-bovine serum albumin across bovine pulmonary artery endothelial cell monolayers. In the presence of serum, a 6-h exposure to lipopolysaccharide (10 ng/ml) increased transendothelial 14C-albumin flux compared to the simultaneous media control. Coadministration of endotoxin-neutralizing protein (> or =10 ng/ml) with lipopolysaccharide (10 ng/ml) protected against lipopolysaccharide-induced barrier dysfunction. This protection was dose dependent, conferring total protection at endotoxin-neutralizing protein/lipopolysaccharide ratios of > or =10:1. Similarly, endotoxin-neutralizing protein was capable of blocking the lipopolysaccharide-induced endothelial cell responses that are prerequisite to barrier dysfunction, including tyrosine phosphorylation of paxillin and actin depolymerization. Finally, endotoxin-neutralizing protein cross-protected against lipopolysaccharide derived from diverse gram-negative bacteria. Thus, endotoxin-neutralizing protein offers a novel therapeutic intervention for the vascular endothelial dysfunction of gram-negative sepsis and its attendant endotoxemia.

Application of the tension band technique for arthrodesis of the forefoot and midfoot.

Numerous techniques have been described for the arthrodesis of various forefoot and midfoot joints. These techniques include the use of plates, screws, wires, staples, and Steinman pins. The ease of the dorsal approach in instituting these techniques has persuaded most orthopaedic surgeons to instrument the dorsal, or compression, side of the arthrodesis. By instrumenting the compression side, the deforming forces of the arthrodesis may cause distraction on the plantar side. The use of the tension band technique in foot arthrodeses changes the plantar distraction forces to a compressive force without necessitating the exposure of the plantar surface.

Performance improvement through quality improvement teamwork.

Quality improvement teams have the ability to enhance processes that impact care delivery. Organizations must use a framework for documentation and communication of the team's work that is congruent with expectations by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) and that nurse executives can apply the expectations to the activities of their departments. The author discusses one such framework, based on 1994 standards, and presents a team report form illustrating communication of the team's efforts using JCAHO terminology.

Studies of skin toxicity in vitro: dose-response studies on JB6 cells.

There are many reasons for developing in vitro tests of toxicity including cost, speed, studies of mechanisms, and studies utilizing human cells and tissues. The present study focuses on the development of in vitro tests to predict in vivo toxicity by comparing them to data from the literature. A broad spectrum of model toxic compounds was evaluated for toxicity on mouse skin JB6 cells in culture. These included mercuric chloride, sodium lauryl sulfate, formaldehyde, dimethyl sulfoxide, benzoyl peroxide, and ionomycin, all of which have been proven to be positive in the Draize test or in cutaneous toxicity studies. Cell viability was evaluated every 15 min for up to 1 hr, and then after 24 hr of treatment using the Trypan Blue exclusion method; morphological changes were evaluated using phase-contrast and transmission electron microscopy. Dose- and time-dependent cell death and morphological changes were observed at concentrations ranging from 10(-14) to 10(-2) M. Arbitrary rankings were assigned based on 1) IC50 value estimated from the present data, and 2) in vivo toxicity reported in the Registry of Toxic Effects of Chemical Substances. Good correlation between in vitro and in vivo toxicity based on arbitrary rankings was observed. Thus, these findings suggest that the JB6 cell culture model can be used for predicting in vivo toxicity. In the future, it may be possible to utilize this system for the study of intracellular ionized calcium ([Ca2+]i), and the expression of oncogenes as early indicators of toxicity.

Triathlon injuries. The swim-bike-run how-to for medical practitioners.

The triathlon is becoming one of the favourite pastimes of many of our patients. It carries with it a likelihood of overuse injuries. For most of these conditions, treatment will follow the usual regimens, but a good understanding of the mechanics and training principles will give any practitioner more options in the management of these patients.