1.
J Org Chem
; 75(21): 7412-5, 2010 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20929197
RESUMO
A short, convergent, and selective synthesis of meiogynin A, an inhibitor of the antiapoptotic protein Bcl-xL, has been performed. This synthesis, based on a biomimetic approach, allowed the determination of its absolute configuration. Three isomers of meiogynin A have also been elaborated. One of these was found to be three times more potent than the natural compound.