Is child undernutrition associated with antenatal care attendance in Madhya Pradesh, India?

CONTEXT: There is a paucity of research investigating the association between antenatal care (ANC) attendance and child undernutrition in Madhya Pradesh, India. AIM: To determine whether body weight status in children under the age of 5 years is associated with ANC attendance in Madhya Pradesh. METHODS: A cross-sectional study was carried out using data from India's National Family Health Survey (2005-2006). Bodyweight status (an indicator of undernutrition) was determined using weight-for-age. Descriptive statistics and logistic regression were used to estimate prevalence and obtain adjusted odds ratios (AOR) to investigate associations between ANC indicators and weight-for-age. RESULTS: Majority of children were underweight (55.1%). ANC attendance was inadequate, with only 36.8% of women having four or more visits. None of the ANC indicators were associated with body weight status. Increased child age especially an age of 2 years (AOR 2.29; 1.66-3.15), belonging to a scheduled tribe [ST] (AOR 2.36; CI 1.64-3.39), scheduled caste [SC] (AOR 1.75; CI 1.25-2.45) or other backward caste [OBC] (AOR 1.43; CI 1.08-1.89) were associated with being underweight; a birth weight of ≥2.5 kg was associated with lower relative odds of being underweight (AOR 0.43; CI 0.29-0.64). Mothers who had a normal BMI (AOR 0.66; CI 0.53-0.82) or were overweight (AOR 0.42; CI 0.25-0.69) were less likely to have underweight children. CONCLUSIONS: ANC attendance was not associated with body weight status. Increased child age, low birth weight, poor maternal nutrition status and belonging to SCs, STs or OBCs increased the odds of child undernutrition.

A whole-body model to distinguish excess fluid from the hydration of major body tissues.

BACKGROUND: Excess fluid (ExF) accumulates in the body in many conditions. Currently, there is no consensus regarding methods that adequately distinguish ExF from fat-free mass. OBJECTIVE: The aim was to develop a model to determine fixed hydration constants of primary body tissues enabling ExF to be calculated from whole-body measurements of weight, intracellular water (ICWWB), and extracellular water (ECWWB). DESIGN: Total body water (TBW) and ECWWB were determined in 104 healthy subjects by using deuterium and NaBr dilution techniques, respectively. Body fat was estimated by using a reference 4-component model, dual-energy X-ray absorptiometry, and air-displacement plethysmography. The model considered 3 compartments: normally hydrated lean tissue (NH_LT), normally hydrated adipose tissue (NH_AT), and ExF. Hydration fractions (HF) of NH_LT and NH_AT were obtained assuming zero ExF within the diverse healthy population studied. RESULTS: The HF of NH_LT mass was 0.703 +/- 0.009 with an ECW component of 0.266 +/- 0.007. The HF of NH_AT mass was 0.197 +/- 0.042 with an ECW component of 0.127 +/- 0.015. The ratio of ECW to ICW in NH_LT was 0.63 compared with 1.88 in NH_AT. ExF can be estimated with a precision of 0.5 kg. CONCLUSIONS: To calculate ExF over a wide range of body compositions, it is important that the model takes into account the different ratios of ECW to ICW in NH_LT and NH_AT. This eliminates the need for adult age and sex inputs into the model presented. Quantification of ExF will be beneficial in the guidance of treatment strategies to control ExF in the clinical setting.

Two-component models are of limited value for the assessment of body composition in patients with cirrhosis.

BACKGROUND: Most techniques for measuring body composition are based on 2-component models (2-CMs) and depend on assumptions relating to the constancy of the density (D(FFM)) and hydration fraction (HF(FFM)) of fat-free mass (FFM). OBJECTIVES: The objectives were to determine whether these assumptions are systematically violated in patients with cirrhosis and to assess the validity of the estimates of body composition obtained in these patients by using 2-CM techniques. DESIGN: Body composition was assessed by using a 4-component model (4-CM), which was based on data obtained from densitometry, deuterium dilution, and dual-energy X-ray absorptiometry, in 20 patients with cirrhosis who had no evidence of fluid retention and in 20 pair-matched healthy control subjects. The results were compared with those obtained by using "reference" and "bedside" 2-CM techniques. RESULTS: The mean (+/-SD) D(FFM) was significantly lower in the patients with cirrhosis (1.091 +/- 0.008 compared with 1.100 +/- 0.006 kg/L; P < 0.001); no significant difference in HF(FFM) was observed between the patients and control subjects (74.5 +/- 2.6 compared with 73.5 +/- 2.1), although there was greater variability in the patients. Significant differences were observed in the body-composition variables obtained by using the "reference" 2-CM techniques compared with the 4-CM-the 95% limits of agreement in the patients with cirrhosis exceeded 5% body fat and 3 kg FFM; the corresponding values for the "bedside" 2-CM techniques were 11% body fat and 7.5 kg FFM. CONCLUSIONS: Assumptions relating to the constancy of the D(FFM) and HF(FFM) are violated in patients with cirrhosis. Thus, standard 2-CM techniques provide inaccurate body composition estimates in this patient population.

Body fluid volume determination via body composition spectroscopy in health and disease.

The assessment of extra-, intracellular and total body water (ECW, ICW, TBW) is important in many clinical situations. Bioimpedance spectroscopy (BIS) has advantages over dilution methods in terms of usability and reproducibility, but a careful analysis reveals systematic deviations in extremes of body composition and morbid states. Recent publications stress the need to set up and validate BIS equations in a wide variety of healthy subjects and patients with fluid imbalance. This paper presents two new equations for determination of ECW and ICW (referred to as body composition spectroscopy, BCS) based on Hanai mixture theory but corrected for body mass index (BMI). The equations were set up by means of cross validation using data of 152 subjects (120 healthy subjects, 32 dialysis patients) from three different centers. Validation was performed against bromide/deuterium dilution (NaBr, D2O) for ECW/TBW and total body potassium (TBK) for ICW. Agreement between BCS and the references (all subjects) was -0.4 +/- 1.4 L (mean +/- SD) for ECW, 0.2 +/- 2.0 L for ICW and -0.2 +/- 2.3 L for TBW. The ECW agreement between three independent reference methods (NaBr versus D2O-TBK) was -0.1 +/- 1.8 L for 74 subjects from two centers. Comparing the new BCS equations with the standard Hanai approach revealed an improvement in SEE for ICW and TBW by 0.6 L (24%) for all subjects, and by 1.2 L (48%) for 24 subjects with extreme BMIs (<20 and >30). BCS may be an appropriate method for body fluid volume determination over a wide range of body compositions in different states of health and disease.