Antiadenovirus drug discovery: potential targets and evaluation methodologies.

Human adenoviruses (HAdV) are the cause of many acute infections, mostly in the respiratory and gastrointestinal (GI) tracts, as well as conjunctivitis. HAdV diseases in immunocompetent individuals are mostly self-limiting; however, in immunocompromised individuals, especially in pediatric units, HAdV infections are the cause of high morbidity and mortality. Despite the significant clinical impact, there are currently no approved antiviral therapies for HAdV infections. Here, we provide an overview of the different targets that could be considered for the design of specific drugs against HAdV, as well as the available in vitro and in vivo tools for the screening and evaluation of candidate molecules.

Hallazgos histopatológicos en biopsias de cérvix de pacientes con diagnóstico citológico de atipia de células escamosas de significado indeterminado / Histopathological findings in cervical biopsies from patients with cytological diagnosis of atypical squamous cells of undetermined significance

Introducción: la atipia de células escamosas de significado indeterminado se refiere a cambios citológicos sugestivos de lesión intraepitelial de bajo grado, pero insuficientes para una interpretación definitiva. En nuestro medio, no se conoce la frecuencia de lesiones displásicas en pacientes con atipia de células escamosas de significado indeterminado y no hay certeza de cuál es el abordaje clínico más adecuado. Objetivo: describir los hallazgos histopatológicos en las biopsias o conizaciones realizadas por atipia de células escamosas de significado indeterminado y determinar la necesidad de toma de biopsia en estas pacientes...

Introduction: The term atypical squamous cells of undetermined significance refers to cytological changes suggestive of low-grade intraepithelial lesion that are insufficient for a definitive interpretation. In our region, there are no studies evaluating the frequency of dysplastic lesions in patients with atypical squamous cells of undetermined significance and there is no certainty about the most appropriate management. Aim: To describe the histopathological findings in biopsies or conizations performed after a diagnosis of atypical squamous cells of undetermined significance was made on cytology, and to determine the need for biopsy in these patients...