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1.
Educ Inf Technol (Dordr) ; : 1-22, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36688215

RESUMO

The main objective of this study is to investigate the relationships between digital distraction, perceived learning, and general satisfaction in emergency remote teaching. Correlational design, one of the quantitative research methods, was used for the study. The study sample consists of 1532 university students in a Turkish university during Covid-19. The study results show a significant relationship between digital distraction, general satisfaction, and perceived learning. Digital distraction is negatively related to general satisfaction and perceived learning, and general satisfaction is positively related to perceived learning. When the independent demographic variables were analyzed, digital distraction scores were higher for females, those not working in any job, not participate orientation training, and not following the live class and watching it later. In addition, it was revealed that as the age of the students decreased, the digital distraction scores increased. It was found that digital distraction variables, the amount of digital distraction, sending instant messages, checking the time, boredom, sharing social media, and system usability were significant predictors of digital distraction.

2.
Mol Biol Rep ; 39(12): 10249-55, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23053933

RESUMO

In order to investigate an association between alcohol consumption and lysosomal cysteine protease induced pancreatic injury and preventive effect of gallic acid as dose-dependent, we determined myeloperoxidase and malondialdehyde levels, serum amylase activities and cathepsin B and L activities in the cytosolic and lysosomal fractions of pancreatic tissue in the ethanol (8 g/kg) and ethanol plus gallic acid (at different doses 50, 100 and 200 mg/kg) given rats. Absolute ethanol (8 g/kg) was given by oral gavage. Gallic acid was dissolved in the saline (2 ml/kg) and administered before 30 min the oral administration of ethanol. Pancreatic myeloperoxidase and also malondialdehyde levels and serum amylase activities were measured. Besides, histological investigations were made. Cathepsin B activities in the cytosolic fraction were decreased by gallic acid (200 mg/kg) and increased in ethanol given rats. Cytosolic/lysosomal ratio of cathepsin B and L were found to be low in the all doses of gallic acid as compared to ethanol group. Serum amylase, pancreatic myeloperoxidase activities and malondialdehyde levels in the ethanol group were higher than in the control group. These were not statistically significant for myeloperoxidase and malondialdehyde. Also, our histopathologic results indicated that ethanol administration increased pancreatic tissue injury. Gallic acid especially at 200 mg/kg improved ethanol-mediated pancreatic tissue damage.In conclusion, gallic acid treatments were decreased release of lysosomal cathepsin B and L enzymes into cytoplasmic fraction and prevented alcohol mediated pancreatic tissue injury. Preventive effect of gallic acid might be dose-dependent.


Assuntos
Catepsina B/metabolismo , Catepsina L/metabolismo , Sequestradores de Radicais Livres/administração & dosagem , Ácido Gálico/administração & dosagem , Pancreatite Alcoólica/prevenção & controle , Células Acinares/efeitos dos fármacos , Células Acinares/metabolismo , Células Acinares/patologia , Amilases/sangue , Animais , Citosol/enzimologia , Etanol , Feminino , Sequestradores de Radicais Livres/farmacologia , Ácido Gálico/farmacologia , Lisossomos/enzimologia , Malondialdeído/metabolismo , Pâncreas/efeitos dos fármacos , Pâncreas/enzimologia , Pâncreas/patologia , Pancreatite Alcoólica/sangue , Pancreatite Alcoólica/induzido quimicamente , Pancreatite Alcoólica/enzimologia , Peroxidase/metabolismo , Ratos , Ratos Sprague-Dawley
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