Assuntos
Doenças Ósseas Metabólicas/patologia , Ossificação Heterotópica/patologia , Pseudopseudo-Hipoparatireoidismo/patologia , Dermatopatias Genéticas/patologia , Pele/patologia , Doenças Ósseas Metabólicas/genética , Cromograninas/genética , Subunidades alfa Gs de Proteínas de Ligação ao GTP/genética , Humanos , Lactente , Masculino , Mutação , Ossificação Heterotópica/genética , Pseudopseudo-Hipoparatireoidismo/genética , Dermatopatias Genéticas/genéticaRESUMO
BACKGROUND: Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumour, the incidence of which is increasing. Second malignancies have been reported to occur with high incidence in these patients. OBJECTIVES: We report the rate and nature of multiple malignancies in patients with MCC treated over a 10 year period in Addenbrooke's Hospital in Cambridge, United Kingdom, as well as the temporal relationship of these additional malignancies to the diagnosis of MCC. RESULTS: The 27 patients had an approximately equal sex incidence with a median age at diagnosis of 79 years. Seventy percent (n=19) of patients had a second primary malignant tumour; and 7 of these patients had two or more tumours in addition to the MCC. Eighteen patients had additional cutaneous malignancies: melanoma, squamous cell carcinoma and basal cell carcinoma, and 8 patients presented non-cutaneous malignancy including colorectal, haematological and breast tumours. Of the 28 additional tumours in our patients, half were diagnosed prior to presentation of MCC, 32% within 6 months of diagnosis, and 18% between 6 months and 3 years after diagnosis. Possible reasons for the high rate of additional tumours in this population are discussed. CONCLUSIONS: Our figures reflect a higher incidence of multiple malignancies in those with Merkel cell tumour than has previously been reported. This has important implications for the care and surveillance of these patients.
Assuntos
Carcinoma de Célula de Merkel/complicações , Neoplasias Primárias Múltiplas/complicações , Neoplasias Cutâneas/complicações , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reino UnidoRESUMO
We describe an unusual case of generalized granuloma annulare (GA) in a 70-year-old man. This occurred in a photosensitive distribution, responded rapidly to topical and systemic treatment, and resolved leaving residual scarring and milia. To our knowledge, this is the first report of the occurrence of milia formation and scarring in association with GA.
