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4.
Nurs Sci Q ; 31(4): 369-373, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30223753

RESUMO

Today's bedside nurse communicates with patients in an environment that incorporates a wide variety of technology, from simple instruments such as a penlight to complex devices including cellphones, interactive computers, and computerized intravenous pumps. This is an excellent time to examine communication between the nurse and patient in today's fast-paced, technologically driven environment. Orlando's theory of the dynamic nurse-patient relationship provides a theoretical framework for understanding that communication. The proposed model affords a visual demonstration to assist in teaching communication.


Assuntos
Comunicação , Relações Enfermeiro-Paciente , Teoria de Enfermagem , Política de Saúde , Humanos
5.
Brain Behav Immun ; 64: 173-179, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28286301

RESUMO

Hypoxic-ischemic (HI) brain injury is recognized as a significant problem in the perinatal period, contributing to life-long language-learning and other cognitive impairments. Central auditory processing deficits are common in infants with hypoxic-ischemic encephalopathy and have been shown to predict language learning deficits in other at risk infant populations. Inter-alpha inhibitor proteins (IAIPs) are a family of structurally related plasma proteins that modulate the systemic inflammatory response to infection and have been shown to attenuate cell death and improve learning outcomes after neonatal brain injury in rats. Here, we show that systemic administration of IAIPs during the early HI injury cascade ameliorates complex auditory discrimination deficits as compared to untreated HI injured subjects, despite reductions in brain weight. These findings have significant clinical implications for improving central auditory processing deficits linked to language learning in neonates with HI related brain injury.


Assuntos
alfa-Globulinas/administração & dosagem , Transtornos da Percepção Auditiva/tratamento farmacológico , Hipóxia-Isquemia Encefálica/complicações , Estimulação Acústica , Animais , Animais Recém-Nascidos , Transtornos da Percepção Auditiva/etiologia , Transtornos da Percepção Auditiva/fisiopatologia , Sinais (Psicologia) , Discriminação Psicológica/efeitos dos fármacos , Masculino , Ratos Wistar
6.
Behav Brain Res ; 302: 88-99, 2016 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-26778784

RESUMO

Neonatal cerebral hypoxia-ischemia (HI) commonly results in cognitive and sensory impairments. Early behavioral experience has been suggested to improve cognitive and sensory outcomes in children and animal models with perinatal neuropathology. In parallel, we previously showed that treatment with immunomodulator Inter-alpha Inhibitor Proteins (IAIPs) improves cellular and behavioral outcomes in neonatal HI injured rats. The purpose of the current study was to evaluate the influences of early experience and typical maturation in combination with IAIPs treatment on spatial working and reference memory after neonatal HI injury. A second aim was to determine the effects of these variables on hippocampal CA1 neuronal morphology. Subjects were divided into two groups that differed with respect to the time when exposed to eight arm radial water maze testing: Group one was tested as juveniles (early experience, Postnatal day (P) 36-61) and adults (P88-113), and Group two was tested in adulthood only (P88-113; without early experience). Three treatment conditions were included in each experience group (HI+Vehicle, HI+IAIPs, and Sham subjects). Incorrect arm entries (errors) were compared between treatment and experience groups across three error types (reference memory (RM), working memory incorrect (WMI), working memory correct (WMC)). Early experience led to improved working memory performance regardless of treatment. Combining IAIPs intervention with early experience provided a long-term behavioral advantage on the WMI component of the task in HI animals. Anatomically, early experience led to a decrease in the average number of basal dendrites per CA1 pyramidal neuron for IAIP treated subjects and a significant reduction in basal dendritic length in control subjects, highlighting the importance of pruning in typical early life learning. Our results support the hypothesis that early behavioral experience combined with IAIPs improve outcome on a relativity demanding cognitive task, beyond that of a single intervention strategy, and appears to facilitate neuronal plasticity following neonatal brain injury.


Assuntos
Envelhecimento , alfa-Globulinas/farmacologia , Hipóxia-Isquemia Encefálica/complicações , Transtornos da Memória , Memória de Curto Prazo/fisiologia , Plasticidade Neuronal/fisiologia , Análise de Variância , Animais , Animais Recém-Nascidos , Região CA1 Hipocampal/patologia , Dendritos/efeitos dos fármacos , Dendritos/patologia , Dendritos/ultraestrutura , Modelos Animais de Doenças , Hipóxia-Isquemia Encefálica/patologia , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Transtornos da Memória/tratamento farmacológico , Transtornos da Memória/etiologia , Transtornos da Memória/patologia , Memória de Curto Prazo/efeitos dos fármacos , Plasticidade Neuronal/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Neurônios/ultraestrutura , Ratos , Ratos Wistar , Coloração pela Prata
7.
ANS Adv Nurs Sci ; 39(1): 3-14, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26539694

RESUMO

This author explored the culture of nurse-patient interactions associated with electronic bedside documentation. Data were collected through passive participant observation, audiotaping of nurse-patient interactions, and interviews with nurses. Nurses acknowledged that they need to share their attention between the patient and the computer. They stated that prioritizing patients' needs while completing the required electronic documentation was demanding. Stationary computers challenged the logistics of the exchange. Understanding the adaptation of caregiving necessitated by bedside electronic documentation will have a positive impact on developing systems that interface seamlessly with nurses' workflow and encourage patients' active participation in their care.


Assuntos
Sistemas Computadorizados de Registros Médicos , Relações Enfermeiro-Paciente , Registros de Enfermagem , Sistemas Automatizados de Assistência Junto ao Leito , Sistemas de Informação Hospitalar , Humanos
8.
Exp Neurol ; 261: 424-33, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25084519

RESUMO

Hypoxic-ischemic (HI) brain injury is frequently associated with premature and/or full term birth related complications. HI injury often results in learning and processing deficits that reflect widespread damage to an extensive range of cortical and sub-cortical brain structures. Further, inflammation has been implicated in the long-term progression and severity of HI injury. Recently, inter-alpha inhibitor proteins (IAIPs) have been shown to attenuate inflammation in models of systemic infection. Importantly, preclinical studies of neonatal HI injury and neuroprotection often focus on single time windows of assessment or single behavioral domains. This approach limits translational validity, given evidence for a diverse spectrum of neurobehavioral deficits that may change across developmental windows following neonatal brain injury. Therefore, the aims of this research were to assess the effects of human IAIPs on early neocortical cell death (72h post-insult), adult regional brain volume measurements (cerebral cortex, hippocampus, striatum, corpus callosum) and long-term behavioral outcomes in juvenile (P38-50) and adult (P80+) periods across two independent learning domains (spatial and non-spatial learning), after postnatal day 7 HI injury in rats. Here, for the first time, we show that IAIPs reduce acute neocortical neuronal cell death and improve brain weight outcome 72h following HI injury in the neonatal rat. Further, these longitudinal studies are the first to show age, task and treatment dependent improvements in behavioral outcome for both spatial and non-spatial learning following systemic administration of IAIPs in neonatal HI injured rats. Finally, results also show sparing of brain regions critical for spatial and non-spatial learning in adult animals treated with IAIPs at the time of injury onset. These data support the proposal that inter-alpha inhibitor proteins may serve as novel therapeutics for brain injury associated with premature birth and/or neonatal brain injury and highlight the importance of assessing multiple ages, brain regions and behavioral domains when investigating experimental treatment efficacy.


Assuntos
Envelhecimento/fisiologia , alfa-Globulinas/uso terapêutico , Lesões Encefálicas/complicações , Deficiências da Aprendizagem/tratamento farmacológico , Deficiências da Aprendizagem/etiologia , Envelhecimento/efeitos dos fármacos , Análise de Variância , Animais , Animais Recém-Nascidos , Encéfalo/efeitos dos fármacos , Encéfalo/crescimento & desenvolvimento , Encéfalo/patologia , Lesões Encefálicas/patologia , Morte Celular/efeitos dos fármacos , Modelos Animais de Doenças , Humanos , Masculino , Tamanho do Órgão/efeitos dos fármacos , Ratos , Ratos Wistar , Tempo de Reação/efeitos dos fármacos , Aprendizagem Espacial/efeitos dos fármacos , Aprendizagem Espacial/fisiologia , Resultado do Tratamento
9.
J Vis Exp ; (82): 50940, 2013 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-24335781

RESUMO

Working and reference memory are commonly assessed using the land based radial arm maze. However, this paradigm requires pretraining, food deprivation, and may introduce scent cue confounds. The eight-arm radial water maze is designed to evaluate reference and working memory performance simultaneously by requiring subjects to use extra-maze cues to locate escape platforms and remedies the limitations observed in land based radial arm maze designs. Specifically, subjects are required to avoid the arms previously used for escape during each testing day (working memory) as well as avoid the fixed arms, which never contain escape platforms (reference memory). Re-entries into arms that have already been used for escape during a testing session (and thus the escape platform has been removed) and re-entries into reference memory arms are indicative of working memory deficits. Alternatively, first entries into reference memory arms are indicative of reference memory deficits. We used this maze to compare performance of rats with neonatal brain injury and sham controls following induction of hypoxia-ischemia and show significant deficits in both working and reference memory after eleven days of testing. This protocol could be easily modified to examine many other models of learning impairment.


Assuntos
Lesões Encefálicas/fisiopatologia , Aprendizagem em Labirinto , Transtornos da Memória/fisiopatologia , Memória/fisiologia , Natação , Animais , Hipóxia-Isquemia Encefálica/fisiopatologia , Camundongos , Ratos
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