[Ultrasound-guided continuous fascia iliaca compartment block for perioperative pain management in elderly patients undergoing hip fracture surgery].

OBJECTIVE: To study the effect of ultrasound-guided fascia iliaca compartment block on perioperative analgesia and postoperative complications in geriatric patients with hip fractures. METHODS: A total of 127 elderly patients undergoing hip fracture surgery from January 2021 to September 2021 were randomized to receive ultrasound-guided continuous fascia iliaca compartment block(group F) either intravenous analgesia control group(group C). There were 62 cases in group F, including 19 males and 43 females with an average age of (82.4±7.2) years old ranging from 66 to 95 years old, involving 25 femoral neck fractures and 37 femoral intertrochanteric fractures. There were 65 cases in control group, including 18 males and 47 females, with an average age of (81.4±8.7) years old ranging from 65 to 94 years old, involving 29 femoral neck fractures and 36 femoral intertrochanteric fractures. The visual analogue scale(VAS), minimental state examination (MMSE), observer's assessment of alertness/sedation(OAA/S) scale, modified Bromage score, postoperative complications and general conditions during hospitalization in two groups were observed. RESULTS: The resting and exercise VAS at 30 min after block, anesthesia placement and 6, 24 and 48 h after surgery were lower than those in group C(P<0.05). In group F, MMSE scores at 12 h before surgery, and 1, 3 d after surgery and OAA/S scores at 3 d after surgery were higher than those in group C(P<0.05). The incidence of adverse effects and the number requiring additional analgesia were lower than those in group C(P<0.05). Group F had better perioperative analgesia satisfaction and hospital stay than group C(P<0.05). But there was no significant difference regarding Bromage score and 30-day mortality between two group(P>0.05). CONCLUSION: Ultrasound-guided continuous fascia iliacus space block was safe and effective for elderly patients with hip fracture, and could significantly reduce perioperative pain, improve postoperative cognitive function, and reduce postoperative complications, thereby shortening hospital stay and improving the quality of life during hospitalization.

Effect of transcutaneous electrical acupoint stimulation on postoperative pain in pediatric orthopedic surgery with the enhanced recovery after surgery protocol: a prospective, randomized controlled trial.

STUDY OBJECTIVE: To evaluate the safety and effectiveness of transcutaneous electrical acupoint stimulation (TEAS) in postoperative analgesia following pediatric orthopedic surgery with the enhanced recovery after surgery (ERAS) protocol. DESIGN: Prospective randomized controlled trial. SETTING: The Seventh Medical Center of the Chinese People's Liberation Army General Hospital. PARTICIPANTS: Eligible participants were children aged 3-15 years who were scheduled to undergo orthopedic surgery of the lower extremities under general anesthesia. INTERVENTIONS: A total of 58 children were randomly allocated into two groups: TEAS (n = 29) and sham-TEAS (n = 29). The ERAS protocol was used in both groups. In the TEAS group, the bilateral Hegu (LI4) and Neiguan (PC6) acupoints were stimulated starting from 10 min before anesthetic induction until the completion of surgery. In the sham-TEAS group, the electric stimulator was also connected to the participants; however, electrical stimulation was not applied. MEASURES: The primary outcome was the severity of pain before leaving the post-anesthesia care unit (PACU) and at postoperative 2 h, 24 h, and 48 h. Pain intensity was measured with the Faces Pain Scale-Revised (FPS-R). RESULTS: None of the participants had any TEAS-related adverse reactions. In comparison with the sham-TEAS group, FPS-R scores in the TEAS group were significantly decreased before leaving the PACU and at postoperative 2 h and 24 h (p < 0.05). The incidence of emergence agitation, intraoperative consumption of remifentanil, and time to extubation were significantly reduced in the TEAS group. Furthermore, the time to first press of the patient-controlled intravenous analgesia (PCIA) pump was significantly longer, the pressing times of the PCIA pump in 48 h after surgery was significantly decreased, and parental satisfaction was significantly improved (all p < 0.05). CONCLUSION: TEAS may safely and effectively relieve postoperative pain and reduce the consumption of perioperative analgesia in children following orthopedic surgery with the ERAS protocol. TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR2200059577), registered on May 4, 2022.

Double ryanodine receptor mutations confer higher diamide resistance in rice stem borer, Chilo suppressalis.

BACKGROUND: The striped rice stem borer, Chilo suppressalis (Lepidoptera: Pyraidae), is one of the most serious rice pests in China. Chlorantraniliprole was used extensively for C. suppressalis control over the past ten years, and some field populations have developed high resistance. In this study, we report the chlorantraniliprole resistance status of C. suppressalis in China and the resistance mechanism. RESULTS: Significant geographical variations of chlorantraniliprole susceptibility were observed among 28 C. suppressalis field populations in 2019-2020. The LC50 values varied from 2907.874 mg L-1 (XS19) to 1.524 mg L-1 (QW19). Most tested field populations collected from Zhejiang, Jiangxi, Hunan and Anhui provinces in 2020 showed a high level of resistance to chlorantraniliprole (RR = 311.9-2060.1), whereas Jiangsu and Sichuan province populations remained susceptible. Analysis of RyR mutations showed that mutations of I4758M, Y4667D, Y4667C and Y4891F were present in resistant populations of C. suppressalis with different levels of chlorantraniliprole resistance. The frequency of the Y4667C mutation was correlated with chlorantraniliprole resistance in YY19 (RR = 702.6) and YY20 (RR = 1426.8) populations, with the homozygous mutation frequencies of 15.6% and 29.4%, respectively. High contributions of the I4758M and Y4667C double mutation to diamide resistance was demonstrated with CRISPR/Cas9-modified D. melanogaster. Flies bearing the Y4667C mutation (I4758M and Y4667C double mutation in C. suppressalis) exhibited high resistance to chlorantraniliprole (RR = 172.1), and moderate resistance to cyantraniliprole (RR = 79.2) and tetra chlorantraniliprole (RR = 43.6), which were higher than that of single mutations. CONCLUSIONS: Chlorantraniliprole resistance in C. suppressalis is intensifying in China. RyR double mutations (i.e. I4758M and Y4667C) confer higher diamide resistance than single mutations.

Higher order correlations in a levitated nanoparticle phonon laser.

We present theoretical and experimental investigations of higher order correlations of mechanical motion in the recently demonstrated optical tweezer phonon laser, consisting of a silica nanosphere trapped in vacuum by a tightly focused optical beam [R. M. Pettit et al., Nature Photonics 13, 402 (2019)]. The nanoparticle phonon number probability distribution is modeled with the master equation formalism in order to study its evolution across the lasing threshold. Up to fourth-order equal-time correlation functions are then derived from the probability distribution. Subsequently, the master equation is transformed into a nonlinear quantum Langevin equation for the trapped particle's position. This equation yields the non-equal-time correlations, also up to fourth order. Finally, we present experimental measurements of the phononic correlation functions, which are in good agreement with our theoretical predictions. We also compare the experimental data to existing analytical Ginzburg-Landau theory where we find only a partial match.

The Time-Concentration-Mortality Responses of Western Flower Thrips, Frankliniella occidentalis, to the Synergistic Interaction of Entomopathogenic Fungus Metarhizium flavoviride, Insecticides, and Diatomaceous Earth.

Western flower thrips (WFT), Frankliniella occidentalis (Pergande), is a highly invasive pest which is harmful to many cash crops globally and resistant to various insecticides. Entomopathogenic fungi (EPF), as biological control agents, have demonstrated a good control effect on WFT. The aim of this study was to evaluate the synergistic and pathogenicity efficacy of the fungal strain Metarhizium flavoviride WSWL51721 when distributed with diatomaceous earth (DE) and the active ingredient imidacloprid using four bioassay methods against adult and second instar larvae of WFT. The data of the four bioassays have been fitted to the time-concentration-mortality (TCM) model. The corrected mortality ranges of WFT adults were 75-100%, 82.69-100%, 78.85-100%, and 92.31-100%, and the corrected mortality ranges of WFT second instar larvae were 72.22-100%, 85.19-100%, 77.77-100%, and 100% in the four bioassays at concentrations of 1.2 × 106 to 1.2 × 108 conidia/mL, respectively. At 1.2 × 108 conidia/mL, assays 2 (M. flavoviride with DE), 3 (M. flavoviride with imidacloprid), and 4 (M. flavoviride with DE and imidacloprid) had the shortest median lethal time (LT50), compared with that of assay 1 (M. flavoviride alone) for adults at 2.26 d, 2.06 d, and 1.53 d, and second instar larvae at 2.45 d, 1.70 d, and 1.41 d, respectively. The median lethal concentration (LC50) in the four bioassays decreased within 3-10 days of inoculation. On the third day, it was found that the lowest median lethal concentrations in assays 2, 3, and 4 were 1.58 × 107, 1.13 × 107, and 3.39 × 106 conidia/mL, respectively, which were significantly different from that in assay 1 for the adults. For the second instar larvae, assays 2, 3, and 4 also had the lowest lethal concentrations and were significantly different from those of assay 1. There were significant differences in sporulation between adults and second instar larvae under the four bioassays. Our results indicate that assays 2 (M. flavoviride with DE), 3 (M. flavoviride with imidacloprid), and 4 (M. flavoviride with DE and imidacloprid) demonstrate synergistic effects on the control of both adult and second instar larvae of WFT under laboratory conditions.

Optical nonreciprocity and slow light in coupled spinning optomechanical resonators.

We study the optical transmission characteristics of coupled spinning optomechanical resonators with pump-probe driven lasers. Under the steady-state conditions, we focus on how changing the optical Sagnac effect due to same or opposite spinning directions of the resonators can give rise to non-reciprocal and delayed probe light transmission. We find that coupled resonators can exhibit distinct transmission features, can generate negative group delays (slow as well as fast light) and offer additional control of the probe light transmission as compared to the case of a single spinning resonator. Our results can be useful in achieving chiral light propagation in quantum communication technologies without using traditional magneto-optical means.

Trapped Ion Quantum Information Processing with Squeezed Phonons.

Trapped ions offer a pristine platform for quantum computation and simulation, but improving their coherence remains a crucial challenge. Here, we propose and analyze a new strategy to enhance the coherent interactions in trapped ion systems via parametric amplification of the ions' motion-by squeezing the collective motional modes (phonons), the spin-spin interactions they mediate can be significantly enhanced. We illustrate the power of this approach by showing how it can enhance collective spin states useful for quantum metrology, and how it can improve the speed and fidelity of two-qubit gates in multi-ion systems, important ingredients for scalable trapped ion quantum computation. Our results are also directly relevant to numerous other physical platforms in which spin interactions are mediated by bosons.

Stroboscopic approach to trapped-ion quantum information processing with squeezed phonons.

In trapped-ion quantum information processing, interactions between spins (qubits) are mediated by collective modes of motion of an ion crystal. While there are many different experimental strategies to design such interactions, they all face both technical and fundamental limitations to the achievable coherent interaction strength. In general, obtaining strong interactions and fast gates is an ongoing challenge. Here, we extend previous work [W. Ge, B. C. Sawyer, J. W. Britton, K. Jacobs, J. J. Bollinger, and M. Foss-Feig, Phys. Rev. Lett. 122, 030501 (2019)] and present a general strategy for enhancing the interaction strengths in trapped-ion systems via parametric amplification of the ions' motion. Specifically, we propose a stroboscopic protocol using alternating applications of parametric amplification and spin-motion coupling. In comparison with the previous work, we show that the current protocol can lead to larger enhancements in the coherent interaction that increase exponentially with the gate time.

Heisenberg-scaling measurement protocol for analytic functions with quantum sensor networks.

We generalize past work on quantum sensor networks to show that, for d input parameters, entanglement can yield a factor O(d) improvement in mean-squared error when estimating an analytic function of these parameters. We show that the protocol is optimal for qubit sensors, and we conjecture an optimal protocol for photons passing through interferometers. Our protocol is also applicable to continuous variable measurements, such as one quadrature of a field operator. We outline a few potential applications, including calibration of laser operations in trapped ion quantum computing.

Distributed Quantum Metrology with Linear Networks and Separable Inputs.

We derive a bound on the ability of a linear-optical network to estimate a linear combination of independent phase shifts by using an arbitrary nonclassical but unentangled input state, thereby elucidating the quantum resources required to obtain the Heisenberg limit with a multiport interferometer. Our bound reveals that while linear networks can generate highly entangled states, they cannot effectively combine quantum resources that are well distributed across multiple modes for the purposes of metrology: In this sense, linear networks endowed with well-distributed quantum resources behave classically. Conversely, our bound shows that linear networks can achieve the Heisenberg limit for distributed metrology when the input photons are concentrated in a small number of input modes, and we present an explicit scheme for doing so.